. . "0730-7268" . . . "Bl\u00E1ha, L." . . "Pl\u00ED\u0161kov\u00E1, M." . . . "aryl hydrocarbon receptor-mediated activity; estrogenicity; intercellular communication inhibition"@en . . . . "A group of heterocyclic aromatic compounds, dinaphthofurans (DNFs), recently have been identified as potentially significant contaminants in freshwater sediments. In the present study, a battery of in vitro assays was used for detection of toxic effects of DNFs that are potentially associated with endocrine disruption and tumor promotion. Dinaphthofurans were found to act as relatively potent inducers of aryl hydrocarbon receptor (AhR)-mediated activity in the chemical-activated luciferase reporter gene expression DR-CALUX assay. The relative AbR-inducing potencies of DNFs were similar or even higher than relative potencies of unsubstituted polycyclic aromatic hydrocarbons (PAHs), with dinaphtho[1,2-b;2'3'-d]furan being the most potent AhR agonist." . "Induction of aryl hydrocarbon receptor-mediated and estrogen receptor-mediated activities, and modulation of cell proliferation by dinaphthofurans" . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "A group of heterocyclic aromatic compounds, dinaphthofurans (DNFs), recently have been identified as potentially significant contaminants in freshwater sediments. In the present study, a battery of in vitro assays was used for detection of toxic effects of DNFs that are potentially associated with endocrine disruption and tumor promotion. Dinaphthofurans were found to act as relatively potent inducers of aryl hydrocarbon receptor (AhR)-mediated activity in the chemical-activated luciferase reporter gene expression DR-CALUX assay. The relative AbR-inducing potencies of DNFs were similar or even higher than relative potencies of unsubstituted polycyclic aromatic hydrocarbons (PAHs), with dinaphtho[1,2-b;2'3'-d]furan being the most potent AhR agonist."@en . "23" . "Skupina heterocyklick\u00FDch aromatick\u00FDch slou\u010Denin dinaftofuran\u016F (DNF) byla ned\u00E1vno identifikov\u00E1na jako potenci\u00E1ln\u00ED kontaminanty sladkovodn\u00EDch sediment\u016F. V t\u00E9to studii byla pou\u017Eita baterie in vitro test\u016F k detekci toxick\u00FDch \u00FA\u010Dinku DNF, kter\u00E9 mohou b\u00FDt potenci\u00E1ln\u011B spojeny s naru\u0161en\u00EDm endokrinn\u00ED regulace a n\u00E1dorovou promoc\u00ED. Bylo zji\u0161t\u011Bno, \u017Ee dinaftofurany mohou \u00FA\u010Dinkovat jako relativn\u011B siln\u00E9 induktory aktivity zprost\u0159edkovan\u00E9 receptorem pro aromatick\u00E9 uhlovod\u00EDky (AhR) a stimuluj\u00ED proliferaci kontaktn\u011B inhibovan\u00FDch jatern\u00EDch epiteli\u00E1ln\u00EDch bun\u011Bk potkana. Relativn\u00ED schopnost DNF indukovat AhR byla podobn\u00E1 nebo dokonce vy\u0161\u0161\u00ED ne\u017E u nesubstituovan\u00FDch polycyklick\u00FDch aromatick\u00FDch uhlovod\u00EDk\u016F (PAH), p\u0159i\u010Dem\u017E dinafto[1,2-b;2'3'-d]furan je nejsiln\u011Bj\u0161\u00ED agonista AhR. N\u011Bkter\u00E9 DNF z\u00E1rove\u0148 aktivovaly estrogenn\u00ED receptor."@cs . "[3E8BBF6C086A]" . "567739" . . "7"^^ . "Chramostov\u00E1, Kate\u0159ina" . "Vondr\u00E1\u010Dek, Jan" . "Induction of aryl hydrocarbon receptor-mediated and estrogen receptor-mediated activities, and modulation of cell proliferation by dinaphthofurans" . . . . "Kozub\u00EDk, Alois" . "2214;2220" . "Machala, M." . "9" . "Brack, W." . . "3"^^ . "RIV/68081707:_____/04:00104667!RIV/2005/AV0/A17005/N" . . "Aktivace receptoru pro aromatick\u00E9 uhlovod\u00EDky a estrogenn\u00EDho receptoru, a modulace bun\u011B\u010Dn\u00E9 proliferace dinaftofurany"@cs . "Induction of aryl hydrocarbon receptor-mediated and estrogen receptor-mediated activities, and modulation of cell proliferation by dinaphthofurans"@en . . "7"^^ . "Environmental Toxicology and chemistry" . . "Aktivace receptoru pro aromatick\u00E9 uhlovod\u00EDky a estrogenn\u00EDho receptoru, a modulace bun\u011B\u010Dn\u00E9 proliferace dinaftofurany"@cs . "RIV/68081707:_____/04:00104667" . "P(GA525/03/1527), Z(AV0Z5004920)" . "Induction of aryl hydrocarbon receptor-mediated and estrogen receptor-mediated activities, and modulation of cell proliferation by dinaphthofurans"@en .