"P(IPP1050128), P(QC0194), Z(AV0Z5004920), Z(MSM 141100003)" . "17" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Bl\u00E1ha, L." . . . . "1"^^ . . "V t\u00E9to pr\u00E1ci byla studov\u00E1na s\u00E9rie t\u0159iceti dvou hydroxy a dihydroxy-PCB (OH-PCB) a chinon\u016F odvozen\u00FDch z PCB z hlediska jejich schopnosti potla\u010Dovat mezibun\u011B\u010Dnou komunikaci typu \u201Cgap junction\u201D (GJIC) a aktivovat receptor pro aromatick\u00E9 uhlovod\u00EDky (AhR) a estrogenn\u00ED receptor v bun\u011B\u010Dn\u00FDch modelech jatern\u00EDch a prsn\u00EDch bun\u011Bk. V\u00FDsledky ukazuj\u00ED, \u017Ee metabolity PCB jsou schopny zp\u016Fsobovat \u0159adu \u0161kodliv\u00FDch efekt\u016F, zahrnuj\u00EDce v to inhibici GJIC, aktivitu zprost\u0159edkovanou AhR a (anti)estrogenitu. Inhibice GJIC pomoc\u00ED OH-PCB p\u0159edstavuje nov\u00FD zp\u016Fsob \u00FA\u010Dink\u016F jak n\u00EDzko-chlorovan\u00FDch, tak perzistentn\u00EDch OH-PCB o vy\u0161\u0161\u00ED molekulov\u00E9 v\u00E1ze."@cs . "RIV/68081707:_____/04:00104662!RIV/2005/AV0/A17005/N" . . . "Toxicity of hydroxylated and quinoid PCB metabolites: Inhibition of gap junctional intercellular communication and activation of aryl hydrocarbon and estrogen receptors in hepatic and mammary cells"@en . . "Machala, M." . "Sovadinov\u00E1, I." . "590544" . "Chemical Research in Toxicology" . "RIV/68081707:_____/04:00104662" . "Toxicita hydroxylovan\u00FDch PCB a PCB chinon\u016F: Inhibice mezibun\u011B\u010Dn\u00E9 komunikace typu \u201Cgap junction\u201D a aktivace receptoru pro aromatick\u00E9 uhlovod\u00EDky a estrogenn\u00EDho receptoru v jatern\u00EDch a prsn\u00EDch bu\u0148k\u00E1ch"@cs . "Robertson, L. W." . "Pl\u00ED\u0161kov\u00E1, M." . "In the present study a series of thirty-two hydroxy and dihydroxy-PCBs (OH-PCBs) and PCB-derived quinones were prepared and evaluated for their in vitro potencies to downregulate gap junctional intercellular communication (GJIC) and to activate the aryl hydrocarbon receptor (AhR) and the estrogen receptor in liver and mammary cell models. The results show that oxygenated PCB metabolites are capable of multiple adverse effects, including gap junction inhibition, AhR-mediated activity and (anti)estrogenicity. The inhibition of GJIC by OH-PCBs represents a novel mode of action of both the lower-chlorinated and the persisting high-molecular-weight OH-PCBs." . "Lehmler, H.-J." . . "hydroxylated polychlorinated biphenyls; AhR-mediated activity; inhibition of GJIC"@en . "Vondr\u00E1\u010Dek, Jan" . "10"^^ . "Toxicity of hydroxylated and quinoid PCB metabolites: Inhibition of gap junctional intercellular communication and activation of aryl hydrocarbon and estrogen receptors in hepatic and mammary cells" . "M\u00E1jkov\u00E1, Z." . . "8"^^ . . "0893-228X" . . "Malmberg, T." . "Kapplov\u00E1, P." . "In the present study a series of thirty-two hydroxy and dihydroxy-PCBs (OH-PCBs) and PCB-derived quinones were prepared and evaluated for their in vitro potencies to downregulate gap junctional intercellular communication (GJIC) and to activate the aryl hydrocarbon receptor (AhR) and the estrogen receptor in liver and mammary cell models. The results show that oxygenated PCB metabolites are capable of multiple adverse effects, including gap junction inhibition, AhR-mediated activity and (anti)estrogenicity. The inhibition of GJIC by OH-PCBs represents a novel mode of action of both the lower-chlorinated and the persisting high-molecular-weight OH-PCBs."@en . . . "Toxicity of hydroxylated and quinoid PCB metabolites: Inhibition of gap junctional intercellular communication and activation of aryl hydrocarbon and estrogen receptors in hepatic and mammary cells"@en . "340;347" . "3" . . . . "Toxicity of hydroxylated and quinoid PCB metabolites: Inhibition of gap junctional intercellular communication and activation of aryl hydrocarbon and estrogen receptors in hepatic and mammary cells" . . . . "[08AAE446978D]" . "Toxicita hydroxylovan\u00FDch PCB a PCB chinon\u016F: Inhibice mezibun\u011B\u010Dn\u00E9 komunikace typu \u201Cgap junction\u201D a aktivace receptoru pro aromatick\u00E9 uhlovod\u00EDky a estrogenn\u00EDho receptoru v jatern\u00EDch a prsn\u00EDch bu\u0148k\u00E1ch"@cs .