. . . . "RIV/68081707:_____/04:00104638!RIV/2005/AV0/A17005/N" . "Odli\u0161n\u00E9 rozli\u0161en\u00ED DNA modifikovan\u00E9 nov\u00FDm protin\u00E1dorov\u011B \u00FA\u010Dinn\u00FDm trojjadern\u00FDm komplexem platiny BBR3464 a cisplatinou n\u00E1dorov\u011B supresorov\u00FDm proteinem p53"@cs . "4"^^ . "RIV/68081707:_____/04:00104638" . "Farrell, N." . "V\u00FDsledky ukazuj\u00ED, \u017Ee strukturn\u011B odli\u0161n\u00E9 adukty protin\u00E1dorov\u011B \u00FA\u010Dinn\u00E9ho trojjadern\u00E9ho komplexu platiny BBR3464 a cisplatiny vykazuj\u00ED odli\u0161nou \u00FA\u010Dinnost ovliv\u0148ovat vazebnou afinitu modifikovan\u00E9 DNA k proteinu p53. Bylo navr\u017Eeno, \u017Ee odli\u0161n\u00E1 naru\u0161en\u00ED struktury vyvolan\u00E1 v DNA adukty BBR3464 a cisplatiny jsou sign\u00E1lem pro odli\u0161nou odpov\u011B\u010F na aktivaci proteinu p53."@cs . . "7"^^ . "560575" . . "Nucleic Acids Research" . . . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Ka\u0161p\u00E1rkov\u00E1, Jana" . "Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin" . . "32" . . . "Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin"@en . "5546;5552" . "0305-1048" . . . "Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin"@en . "P(GA204/02/0734), P(IAA5004101), P(IBS5004009), P(KJB5004301), P(KSK4055109), Z(AV0Z5004920)" . "Odli\u0161n\u00E9 rozli\u0161en\u00ED DNA modifikovan\u00E9 nov\u00FDm protin\u00E1dorov\u011B \u00FA\u010Dinn\u00FDm trojjadern\u00FDm komplexem platiny BBR3464 a cisplatinou n\u00E1dorov\u011B supresorov\u00FDm proteinem p53"@cs . "The results indicate that structurally different DNA adducts of antitumor trinuclear platinum compound BBR3464 and cisplatin exhibit a different efficiency to affect the binding affinity of the modified DNA to p53 protein. It has been suggested that different structural perturbations induced in DNA by the adducts of BBR3464 and cisplatin produce differential response to p53 protein activation." . . . . . . . "[06BE8902AECB]" . "Fojta, Miroslav" . . "DNA; platinum; p53"@en . "Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin" . "3"^^ . "18" . . "The results indicate that structurally different DNA adducts of antitumor trinuclear platinum compound BBR3464 and cisplatin exhibit a different efficiency to affect the binding affinity of the modified DNA to p53 protein. It has been suggested that different structural perturbations induced in DNA by the adducts of BBR3464 and cisplatin produce differential response to p53 protein activation."@en . . "Brabec, Viktor" .