. . . "354653" . "Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology" . "000259546400001" . "Abnormal myocardial and coronary vasculature development in experimental hypoxia"@en . "quail embryo; vasculogenesis; coronary artery"@en . "RIV/67985904:_____/08:00316951!RIV09-AV0-67985904" . . . . "P(LC06061), Z(AV0Z50450515), Z(MSM0021620806)" . "2"^^ . "Grim, M." . . . "Oxygen availability is one of the necessary prerequisites for normal embryonic development. In our previous study we found that quail embryos incubated under hypoxic conditions (16% O(2)) die at embryonic day (ED) 9 with signs of heart failure. By ED4 and ED6 we found thinner ventricular wall and increased capillary density. We thus hypothesized that the cause of death would lie in severe myocardial and coronary maldevelopment. ED6 and 7 hypoxic hearts had thinner ventricular wall, especially left. There was a simultaneous increase in capillary density, most pronounced in the interventricular septum. This site corresponds to an area of tissue hypoxia and ensuing increased angiogenesis, and also formation of ventricular conduction system. Hypoxia had a positive effect on normal sequence of maturation of the conduction system evaluated by optical mapping at ED7. In sections from ED9 hypoxic hearts we found, in addition to thinner ventricular walls, irregularities in development of coronary tree (miss..." . . "Blaha, Milan" . . . "Abnormal myocardial and coronary vasculature development in experimental hypoxia" . "7"^^ . "Abnorm\u00E1ln\u00ED v\u00FDvoj myokardi\u00E1ln\u00ED architektury a koron\u00E1rn\u00EDch c\u00E9v za podm\u00EDnek experiment\u00E1ln\u00ED hypoxie"@cs . . "291" . "T\u016Fma, M." . . "Fikrle, M." . "RIV/67985904:_____/08:00316951" . "[4000DD0019D1]" . "Abnormal myocardial and coronary vasculature development in experimental hypoxia"@en . "Na\u0148ka, O." . . "-" . . "13"^^ . "Sedmera, David" . . "Oxygen availability is one of the necessary prerequisites for normal embryonic development. In our previous study we found that quail embryos incubated under hypoxic conditions (16% O(2)) die at embryonic day (ED) 9 with signs of heart failure. By ED4 and ED6 we found thinner ventricular wall and increased capillary density. We thus hypothesized that the cause of death would lie in severe myocardial and coronary maldevelopment. ED6 and 7 hypoxic hearts had thinner ventricular wall, especially left. There was a simultaneous increase in capillary density, most pronounced in the interventricular septum. This site corresponds to an area of tissue hypoxia and ensuing increased angiogenesis, and also formation of ventricular conduction system. Hypoxia had a positive effect on normal sequence of maturation of the conduction system evaluated by optical mapping at ED7. In sections from ED9 hypoxic hearts we found, in addition to thinner ventricular walls, irregularities in development of coronary tree (miss..."@en . "Abnorm\u00E1ln\u00ED v\u00FDvoj myokardi\u00E1ln\u00ED architektury a koron\u00E1rn\u00EDch c\u00E9v za podm\u00EDnek experiment\u00E1ln\u00ED hypoxie"@cs . "K\u0159\u00ED\u017Eov\u00E1, P." . . "Za podm\u00EDnek hypoxick\u00E9 inkubace doch\u00E1z\u00ED v srdci k\u0159epel\u010D\u00EDho z\u00E1rodku ke zmno\u017Een\u00ED kapil\u00E1r a perzistence trabekul. Abnorm\u00E1ln\u00ED p\u0159estavba t\u00E9to primitivn\u00ED cirkulace vede k anom\u00E1li\u00EDm tepenn\u00FDch kmen\u016F, kter\u00E1 vede k fenotypu tenk\u00E9ho kompaktn\u00EDho myokardu a od\u00FAmrti."@cs . "Abnormal myocardial and coronary vasculature development in experimental hypoxia" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . . "1932-8486" .