. "317" . . "\u0160olc, Petr" . . "This paper uses functional studies (RNAi, mRNA microinjection) to uncover a role of CDC25A in female meiosis. CDC25A cooperates together with CDC25B during resumption of meiosis, destruction of CDC25A in prometaphase I is crucial for MI-MII transition. CDC25A is exclusively localized to the nucleus prior to nuclear envelope breakdown (NEBD). In contrast, CDC25B localizes to cytoplasm in GV-intact oocytes and translocates to the nucleus shortly before NEBD. CDC25A behaves differently during female meiosis than during mitosis, and moreover, that CDC25A has a function in resumption of meiosis, MI spindle formation and the MI\u2013MII transition. Thus, both CDC25A and CDC25B are critical for meiotic maturation of oocytes." . "Developmental Biology" . . "Pr\u00E1ce pomoc\u00ED funk\u010Dn\u00EDch studi\u00ED (RNAi, mRNA mikroinjekce) objas\u0148uje roli CDC25A v sami\u010D\u00ED mei\u00F3ze. CDC25A se spolu s CDC25B pod\u00EDl\u00ED na znovuzah\u00E1jen\u00ED mei\u00F3zy, destrukce CDC25A v prometaf\u00E1zi I je kl\u00ED\u010Dov\u00E1 pro MI-MII p\u0159echod. CDC25A je p\u0159ed znovuzah\u00E1jen\u00EDm mei\u00F3zy \u010Dist\u011B jadern\u00FD protein, av\u0161ak CDC25B je nejd\u0159\u00EDve lokalizov\u00E1na do cytoplasmy a t\u011Bsn\u011B p\u0159ed rozpadem jadern\u00E9 membr\u00E1ny se translokuje do j\u00E1dra. CDC25A hraje kl\u00ED\u010Dovou roli v znovuzah\u00E1jen\u00ED mei\u00F3zy, v tvorb\u011B MI spindlu a MI-MII p\u0159echodu."@cs . "CDC25A phosphatase controls meiosis I progression in mouse oocytes"@en . "CDC25A fosfat\u00E1za reguluje pr\u016Fchod mei\u00F3zou I v my\u0161\u00EDch oocytech"@cs . "CDC25A fosfat\u00E1za reguluje pr\u016Fchod mei\u00F3zou I v my\u0161\u00EDch oocytech"@cs . . "358966" . . . . "CDC25A phosphatase controls meiosis I progression in mouse oocytes"@en . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Kubelka, Michal" . . "[D81323E25E44]" . "Baran, V." . . . . "4"^^ . . "RIV/67985904:_____/08:00307953" . "Motl\u00EDk, Jan" . . . "10"^^ . "Schultz, R. M." . "CDC25A phosphatase controls meiosis I progression in mouse oocytes" . "260;269" . "CDC25A phosphatase controls meiosis I progression in mouse oocytes" . "0012-1606" . "resumption of meiosis; meiotic maturation; mouse oocytes"@en . "6"^^ . "RIV/67985904:_____/08:00307953!RIV08-AV0-67985904" . "This paper uses functional studies (RNAi, mRNA microinjection) to uncover a role of CDC25A in female meiosis. CDC25A cooperates together with CDC25B during resumption of meiosis, destruction of CDC25A in prometaphase I is crucial for MI-MII transition. CDC25A is exclusively localized to the nucleus prior to nuclear envelope breakdown (NEBD). In contrast, CDC25B localizes to cytoplasm in GV-intact oocytes and translocates to the nucleus shortly before NEBD. CDC25A behaves differently during female meiosis than during mitosis, and moreover, that CDC25A has a function in resumption of meiosis, MI spindle formation and the MI\u2013MII transition. Thus, both CDC25A and CDC25B are critical for meiotic maturation of oocytes."@en . . . "1" . . "P(GA305/06/1413), P(GD204/05/H023), Z(AV0Z50450515)" . "\u0160a\u0161kov\u00E1, Ad\u00E9la" . . .