"Coupling of the antitumoral enzyme bovine seminal ribonuclease to polyethylene glycol chains increases its systemic efficacy in mice." . . "13" . . . . "Coupling of the antitumoral enzyme bovine seminal ribonuclease to polyethylene glycol chains increases its systemic efficacy in mice."@en . "149;154" . . "Cinatl, J." . "Cin\u00E1tl, J." . . "aspermatogenicity; BS-RNase; neuroblastoma"@en . "0"^^ . "0959-4973" . "0"^^ . "5"^^ . . "Langer, K." . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . . "Matou\u0161ek, Josef" . . . "1"^^ . . "N/A" . . "[78B23902DB77]" . "RIV/67985904:_____/02:21023018" . "P(GA523/01/0114), P(KSK5052113), Z(AV0Z5045916)" . . "Anti-Cancer Drugs" . . "Coupling of the antitumoral enzyme bovine seminal ribonuclease to polyethylene glycol chains increases its systemic efficacy in mice." . "Kreuter, J." . "RIV/67985904:_____/02:21023018!RIV/2003/AV0/A21003/N" . "641843" . "7"^^ . "Coupling of the antitumoral enzyme bovine seminal ribonuclease to polyethylene glycol chains increases its systemic efficacy in mice."@en . . "Michaelis, M." . "Bovine seminal ribonuclease(BS-RNase) is an antitumoral active enzyme exhibiting specific antitumoral action against a number of different cancer cell lines.However, its systemic use is limited by its pharmacokinetic properties and antigenicity.Therefore, it was conjugated to polyethylene glycol(PEG) chains to overcome these problems. In order to Investigate the antitumoral efficacy of BS-RNase-PEG 'In vivo', preliminary experiments on the effect of the conjugate on neuroblastoma growth in mice were performed in a UKF-NB-3 xenotransplantate model, demonstrating a drastically increased antitumoral activity of the conjugate compared to the free enzyme."@en . "Bovine seminal ribonuclease(BS-RNase) is an antitumoral active enzyme exhibiting specific antitumoral action against a number of different cancer cell lines.However, its systemic use is limited by its pharmacokinetic properties and antigenicity.Therefore, it was conjugated to polyethylene glycol(PEG) chains to overcome these problems. In order to Investigate the antitumoral efficacy of BS-RNase-PEG 'In vivo', preliminary experiments on the effect of the conjugate on neuroblastoma growth in mice were performed in a UKF-NB-3 xenotransplantate model, demonstrating a drastically increased antitumoral activity of the conjugate compared to the free enzyme." . . "Pouckov\u00E1, P." .