. . . . . . . "318191" . . "RIV/67985858:_____/09:00330745!RIV10-MSM-67985858" . "Journal of Medicinal Chemistry" . "C\u00EDgler, Petr" . "000270361600025" . "P(1M0508), P(IAA400720706), Z(AV0Z40550506), Z(AV0Z40720504)" . . "[883B178129D3]" . . . . "Hydroxamic acids as a novel family of serine racemase inhibitors: Mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor"@en . "1"^^ . "Konvalinka, Jan" . "Hydroxamic acids as a novel family of serine racemase inhibitors: Mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor"@en . "0022-2623" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "\u0160anda, Miloslav" . "Mammalian serine racemase (SR) is a pyridoxal-5-phosphate (PLP) dependent enzyme responsible for the biosynthesis of the neurotransmitter d-serine, which activates N-methyl-d-aspartate (NMDA) receptors in the CNS. Aberrant regulation of NMDA receptor signaling has been implicated in a variety of neuropathologies, and inhibitors of SR would therefore be a worthwhile tool for further investigation or treatment of such conditions. Here, we identify a series of small aliphatic hydroxamic acids (HAs) that act as potent SR inhibitors and present a detailed analysis of there mechanism of action."@en . "19" . . . . "Schraml, Jan" . "Hydroxamic acids as a novel family of serine racemase inhibitors: Mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor" . "Hoffman, Hillary Elizabeth" . "Mammalian serine racemase (SR) is a pyridoxal-5-phosphate (PLP) dependent enzyme responsible for the biosynthesis of the neurotransmitter d-serine, which activates N-methyl-d-aspartate (NMDA) receptors in the CNS. Aberrant regulation of NMDA receptor signaling has been implicated in a variety of neuropathologies, and inhibitors of SR would therefore be a worthwhile tool for further investigation or treatment of such conditions. Here, we identify a series of small aliphatic hydroxamic acids (HAs) that act as potent SR inhibitors and present a detailed analysis of there mechanism of action." . . "6"^^ . . "hydroxamic acids; serine racemase; d-serine; pyridoxal-5'-phosphate"@en . "RIV/67985858:_____/09:00330745" . . "Jir\u00E1skov\u00E1, Jana" . . "10"^^ . "Hydroxamic acids as a novel family of serine racemase inhibitors: Mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor" . "52" .