. "Planavila, A." . "Flachs, Pavel" . "Lipids" . "Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids"@en . "16693" . . "We tested whether the beneficial metabolic effects of LC n-3 PUFA involve the induction of Fgf21 in C57BL/6J mice fed high-fat diet (cHF), or a cHF diet supplemented with LC n-3 PUFA (cHF-F) using two experimental settings: shortterm (3 weeks) and long-term treatment (8 weeks). cHF increased plasma Fgf21 levels and hepatic Fgf21 gene expression compared with controls, but these effects were less pronounced or absent in cHF-F-fed mice. In contrast, hepatic expression of peroxisome proliferator-activated receptor (PPAR)-\u03B1 target genes were more strongly induced by cHF-F than cHF, especially in the short-term treatment setting. In the long-term treatment setting, the expression of Fgf21 target genes and receptors was not differentially affected by LC n-3 PUFA. Collectively, our indings indicate that increased Fgf21 levels do not appear to be a major mechanism through which LC n-3 PUFA ameliorates high-fat-diet-associated metabolic disorders" . "RIV/67985823:_____/14:00435667!RIV15-GA0-67985823" . "000344151800001" . "Kopeck\u00FD, Jan" . "I, P(GA13-00871S)" . "10.1007/s11745-014-3948-x" . . "We tested whether the beneficial metabolic effects of LC n-3 PUFA involve the induction of Fgf21 in C57BL/6J mice fed high-fat diet (cHF), or a cHF diet supplemented with LC n-3 PUFA (cHF-F) using two experimental settings: shortterm (3 weeks) and long-term treatment (8 weeks). cHF increased plasma Fgf21 levels and hepatic Fgf21 gene expression compared with controls, but these effects were less pronounced or absent in cHF-F-fed mice. In contrast, hepatic expression of peroxisome proliferator-activated receptor (PPAR)-\u03B1 target genes were more strongly induced by cHF-F than cHF, especially in the short-term treatment setting. In the long-term treatment setting, the expression of Fgf21 target genes and receptors was not differentially affected by LC n-3 PUFA. Collectively, our indings indicate that increased Fgf21 levels do not appear to be a major mechanism through which LC n-3 PUFA ameliorates high-fat-diet-associated metabolic disorders"@en . . . "0024-4201" . "11" . . . . . . . "49" . "3"^^ . "Giralt, M." . "fibroblast growth factor-21; long-chain n-3 polyunsaturated fatty acids"@en . "Villarroya, F." . "[CBE843CF170D]" . . "Redondo-Angulo, I." . "Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids"@en . "Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids" . "8"^^ . . "Med\u0159\u00EDkov\u00E1, Da\u0161a" . "Villarroya, J." . "Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids" . . . "RIV/67985823:_____/14:00435667" . . . "9"^^ . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" .