. . "Preservation of Metabolic Flexibility in Skeletal Muscle by a Combined Use of n-3 PUFA and Rosiglitazone in Dietary Obese Mice" . . "7" . . "Hensler, Michal" . "[7E7BF1CFCAEA]" . "I, P(7E10059), P(GA303/08/0664)" . . . . . . "K\u016Fs, Vladim\u00EDr" . "Preservation of Metabolic Flexibility in Skeletal Muscle by a Combined Use of n-3 PUFA and Rosiglitazone in Dietary Obese Mice"@en . "Hor\u00E1kov\u00E1, Olga" . "Keijer, J." . "RIV/67985823:_____/12:00380295" . . "1932-6203" . . "Kopeck\u00FD, Jan" . "n-3 LC-PUFA; TZD; muscle insulin sensitivity"@en . . "Preservation of Metabolic Flexibility in Skeletal Muscle by a Combined Use of n-3 PUFA and Rosiglitazone in Dietary Obese Mice" . . . . . "We investigated here whether n-3 LC-PUFA could elicit additive beneficial effects on metabolic flexibility when combined with a TZD drug rosiglitazone in mice. Metabolomic and gene expression analyses in the muscle suggested distinct and complementary effects of the interventions, with n-3 LC-PUFA supporting complete oxidation of fatty acids in mitochondria and the combination with n-3 LC-PUFA and rosiglitazone augmenting insulin sensitivity by the modulation of branched-chain amino acid metabolism. These beneficial metabolic effects were associated with the activation of the switch between glycolytic and oxidative muscle fibers, especially in mice fed combined diet of n-3 LC-PUFA and rosiglitazone" . "10"^^ . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "17"^^ . "Preservation of Metabolic Flexibility in Skeletal Muscle by a Combined Use of n-3 PUFA and Rosiglitazone in Dietary Obese Mice"@en . "Adamski, J." . "Bunschoten, A." . . . . "8" . "Prehn, C." . "Flachs, Pavel" . "Bardov\u00E1, Kristina" . "161417" . . . "Rossmeisl, Martin" . . "Med\u0159\u00EDkov\u00E1, Da\u0161a" . "10.1371/journal.pone.0043764" . "Illig, T." . "17"^^ . . "Janovsk\u00E1, Petra" . "van Schothorst, E. M." . "Wang-Sattler, R." . "RIV/67985823:_____/12:00380295!RIV13-GA0-67985823" . . . . "Kuda, Ond\u0159ej" . "000308221300026" . . "PLoS ONE" . "We investigated here whether n-3 LC-PUFA could elicit additive beneficial effects on metabolic flexibility when combined with a TZD drug rosiglitazone in mice. Metabolomic and gene expression analyses in the muscle suggested distinct and complementary effects of the interventions, with n-3 LC-PUFA supporting complete oxidation of fatty acids in mitochondria and the combination with n-3 LC-PUFA and rosiglitazone augmenting insulin sensitivity by the modulation of branched-chain amino acid metabolism. These beneficial metabolic effects were associated with the activation of the switch between glycolytic and oxidative muscle fibers, especially in mice fed combined diet of n-3 LC-PUFA and rosiglitazone"@en .