. "Hensler, Michal" . "Jelen\u00EDk, Tom\u00E1\u0161" . . "Med\u0159\u00EDkov\u00E1, Da\u0161a" . . . "Mik\u0161\u00EDk, Ivan" . "Diabetes" . "17"^^ . . "11"^^ . . . . "0012-1797" . "Mice with a whole-body deletion of the alfa2 catalytic subunit of AMPK and their wild-type littermates were used for testing a hypothesis whether AMP-activated protein kinase (AMPK) has a role in the beneficial effects of n-3 LC-PUFAs. Our results show that n-3 LC-PUFA prevent hepatic insulin resistance in an AMPKalfa2-dependent manner and support the role of adiponectin and hepatic diacylglycerols in the regulation of insulin sensitivity. AMPK\u03B12 is also essential for hypolipidemic and antisteatotic effects of n-3 LC-PUFA under insulin-stimulated conditions" . "284133400009" . . . "Viollet, B." . "[6864E4D32B3F]" . "Mice with a whole-body deletion of the alfa2 catalytic subunit of AMPK and their wild-type littermates were used for testing a hypothesis whether AMP-activated protein kinase (AMPK) has a role in the beneficial effects of n-3 LC-PUFAs. Our results show that n-3 LC-PUFA prevent hepatic insulin resistance in an AMPKalfa2-dependent manner and support the role of adiponectin and hepatic diacylglycerols in the regulation of insulin sensitivity. AMPK\u03B12 is also essential for hypolipidemic and antisteatotic effects of n-3 LC-PUFA under insulin-stimulated conditions"@en . "Flachs, Pavel" . "AMP-activated Protein Kinase alfa2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids" . "AMPK; n-3 LC-PUFA; insulin resistance"@en . "Hawley, S." . "Kuda, Ond\u0159ej" . "P(1M0520), P(GAP301/10/1420), P(OC08007), Z(AV0Z50110509)" . "Rossmeisl, Martin" . "11" . "RIV/67985823:_____/10:00349619!RIV11-GA0-67985823" . "246119" . . "Macek J\u00EDlkov\u00E1, Zuzana" . . . . . . . "K\u016Fs, Vladim\u00EDr" . . "Jensen, T. E." . . . . "Kopeck\u00FD, Jan" . "Gorski, J." . . . "AMP-activated Protein Kinase alfa2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids"@en . "H\u00E9brard, S." . . . . . . "Baranowski, M." . . "Janovsk\u00E1, Petra" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "AMP-activated Protein Kinase alfa2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids"@en . "59" . "RIV/67985823:_____/10:00349619" . "AMP-activated Protein Kinase alfa2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids" . "10"^^ .