"A high rates of mGPDH-dependent ROS production were observed in liver, heart and brain mitochondria treated with antimycin. When related to activity of mGPDH, 3-39-fold higher ROS production was found in contrast to succinate dehydrogenase- or NADH dehydrogenase-dependent ROS production. It was also 22-66 higher compared to that in BAT. Our results demonstrate high efficiency of mGPDH-dependent ROS production localized to the dehydrogenase + CoQ and complex III, in mammalian mitochondria with a low content of mGPDH and suggest its endogenous inhibition in BAT" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "5"^^ . "5"^^ . . "317084" . . . "A high rates of mGPDH-dependent ROS production were observed in liver, heart and brain mitochondria treated with antimycin. When related to activity of mGPDH, 3-39-fold higher ROS production was found in contrast to succinate dehydrogenase- or NADH dehydrogenase-dependent ROS production. It was also 22-66 higher compared to that in BAT. Our results demonstrate high efficiency of mGPDH-dependent ROS production localized to the dehydrogenase + CoQ and complex III, in mammalian mitochondria with a low content of mGPDH and suggest its endogenous inhibition in BAT"@en . "Drahota, Zden\u011Bk" . . . . "High efficiency of ROS production by glycerophosphate dehydrogenase in mammalian mitochondria"@en . "1" . . . . "Mr\u00E1\u010Dek, Tom\u00E1\u0161" . "[480DE921A773]" . "0003-9861" . "High efficiency of ROS production by glycerophosphate dehydrogenase in mammalian mitochondria"@en . "Hou\u0161t\u011Bk, Josef" . "High efficiency of ROS production by glycerophosphate dehydrogenase in mammalian mitochondria" . "RIV/67985823:_____/09:00338638!RIV10-MSM-67985823" . "mGPDH; ROS; mitochondria"@en . . "High efficiency of ROS production by glycerophosphate dehydrogenase in mammalian mitochondria" . "262540500004" . "RIV/67985823:_____/09:00338638" . . . . "Archives of Biochemistry and Biophysics" . . . "P(1M0520), P(GA303/06/1261), Z(AV0Z50110509)" . "481" . . "Pecinov\u00E1, Alena" . "Vrback\u00FD, Marek" . . . "7"^^ . . . . .