"membrane potential; S. cerevisiae; cation fluxes"@en . "262700900022" . "RIV/67985823:_____/09:00323535" . "8"^^ . "325301" . "5" . . "Mare\u0161ov\u00E1, Lydie" . . "Hyperpolarizace membr\u00E1ny je p\u0159\u00ED\u010Dinou vniku kationt\u016F a antifung\u00E1ln\u00ED aktivity amiodaronu"@cs . "Sychrov\u00E1, Hana" . "RIV/67985823:_____/09:00323535!RIV09-AV0-67985823" . . "Membrane Hyperpolarization Drives Cation Influx and Fungicidal Activity of Amiodarone" . "0021-9258" . "Muend, S." . . . . . . . "284" . "5"^^ . . . . "[A8997D4443E2]" . . . "Amiodarone, an ion channel blocker in clinical use as an antiarrhythmic agent, exhibits broad range fungicidal effects. We show that a polarized membrane is critical for drug toxicity; furthermore, the change in membrane potential precedes and is closely coupled to both cation influx and cell death" . "Amiodaron, blok\u00E1tor iontov\u00FDch kan\u00E1l\u016F, kter\u00FD se v klinick\u00E9 praxi pou\u017E\u00EDv\u00E1 pro l\u00E9\u010Dbu srde\u010Dn\u00EDch arytmi\u00ED, m\u00E1 z\u00E1rove\u0148 \u0161irokospektr\u00E9 antifung\u00E1ln\u00ED \u00FA\u010Dinky. Pr\u00E1ce ukazuje, \u017Ee jeho toxick\u00E9 \u00FA\u010Dinky jsou podm\u00EDn\u011Bny elektrochemick\u00FDm potenci\u00E1lem na membr\u00E1n\u011B a \u017Ee zm\u011Bna membr\u00E1nov\u00E9ho potenci\u00E1lu p\u0159edch\u00E1z\u00ED vniku kationt\u016F a bun\u011B\u010Dn\u00E9 smrti"@cs . . "Journal of Biological Chemistry" . "Rao, R." . "2"^^ . "Membrane Hyperpolarization Drives Cation Influx and Fungicidal Activity of Amiodarone" . . . . "Amiodarone, an ion channel blocker in clinical use as an antiarrhythmic agent, exhibits broad range fungicidal effects. We show that a polarized membrane is critical for drug toxicity; furthermore, the change in membrane potential precedes and is closely coupled to both cation influx and cell death"@en . "Zhang, Y. Q." . "Hyperpolarizace membr\u00E1ny je p\u0159\u00ED\u010Dinou vniku kationt\u016F a antifung\u00E1ln\u00ED aktivity amiodaronu"@cs . "Membrane Hyperpolarization Drives Cation Influx and Fungicidal Activity of Amiodarone"@en . "P(KJB500110701), P(LC531), Z(AV0Z50110509)" . . "Membrane Hyperpolarization Drives Cation Influx and Fungicidal Activity of Amiodarone"@en . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" .