"Ras2 Val19 bu\u0148ky s overprodukc\u00ED RAS/protein kin\u00E1zov\u00E9 (PKA) signalizace, vykazuj\u00ED pomalej\u0161\u00ED d\u011Blen\u00ED a p\u0159ed\u010Dasn\u00E9 replikativn\u00ED st\u00E1rnut\u00ED. V pr\u00E1ci ukazujeme, \u017Ee prodlou\u017Een\u00FD genera\u010Dn\u00ED \u010Das je v\u00FDsledkem \u0161patn\u011B funguj\u00EDc\u00ED aktivity mitochondri\u00E1n\u00EDho ATP/ADP p\u0159ena\u0161e\u010De, co\u017E je \u010D\u00E1ste\u010Dn\u011B zp\u016Fsbeno zv\u00FD\u0161nou hladinou reaktivn\u00EDch kysl\u00EDkov\u00FDch radik\u00E1l\u016F (ROS), kter\u00E9 zp\u016Fsobuj\u00ED jeho fragmentaci z\u00E1vislou na proteol\u00FDze. Ras signalizace reguluje d\u011Blen\u00ED a st\u00E1rnut\u00ED dv\u011Bma odli\u0161n\u00FDmi, na kysl\u00EDkov\u00FDch radik\u00E1lech z\u00E1visl\u00FDmi, PKA z\u00E1visl\u00FDmi a nez\u00E1visl\u00FDmi cestami"@cs . . . . "Zv\u00FD\u0161en\u00E1 hladina proteinu Ras/protein kin\u00E1zy A v Saccharomyces cerevisiae sni\u017Euje rychlost proliferace a dobu \u017Eivota dv\u011Bma cestami z\u00E1visl\u00FDmi na reaktivn\u00EDch kysl\u00EDkov\u00FDch radik\u00E1lech"@cs . "Elevated Ras/protein kinase A activity in Saccharomyces cerevisiae reduces proliferation rate and lifespan by two different reactive oxygen species-dependent routes" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "7" . . "10"^^ . . . "2"^^ . "Hlavat\u00E1, Lydie" . "[13B57997DC11]" . "Cells with overactive RAS/protein kinase A (PKA) signaling, RAS2 Val19 cells, exhibit reduced proliferation rates and accelerated replicative senescence. We show that extended generation time is the result of abrogated ATP/ADP carrier activity in mitochondria, partly due to elevated levels of reactive oxygen species (ROS), which cause its proteolysis-dependent fragmentation. Ras signaling affects both ways by two different, ROS-dependent, PKA- dependent and independent routes" . . "P(GP303/05/P100), P(IAA500110701), Z(AV0Z50110509)" . "Elevated Ras/protein kinase A activity in Saccharomyces cerevisiae reduces proliferation rate and lifespan by two different reactive oxygen species-dependent routes"@en . "1474-9718" . "Elevated Ras/protein kinase A activity in Saccharomyces cerevisiae reduces proliferation rate and lifespan by two different reactive oxygen species-dependent routes"@en . "RIV/67985823:_____/08:00306957" . "4"^^ . "Cells with overactive RAS/protein kinase A (PKA) signaling, RAS2 Val19 cells, exhibit reduced proliferation rates and accelerated replicative senescence. We show that extended generation time is the result of abrogated ATP/ADP carrier activity in mitochondria, partly due to elevated levels of reactive oxygen species (ROS), which cause its proteolysis-dependent fragmentation. Ras signaling affects both ways by two different, ROS-dependent, PKA- dependent and independent routes"@en . . . "RIV/67985823:_____/08:00306957!RIV08-AV0-67985823" . . "2" . . "Aging Cell" . "Ras/protein kinase A activity; ROS; Saccharomyces cerevisiae"@en . . . "365984" . . . "Zv\u00FD\u0161en\u00E1 hladina proteinu Ras/protein kin\u00E1zy A v Saccharomyces cerevisiae sni\u017Euje rychlost proliferace a dobu \u017Eivota dv\u011Bma cestami z\u00E1visl\u00FDmi na reaktivn\u00EDch kysl\u00EDkov\u00FDch radik\u00E1lech"@cs . "Nystr\u00F6m, T." . "148;157" . . . "Elevated Ras/protein kinase A activity in Saccharomyces cerevisiae reduces proliferation rate and lifespan by two different reactive oxygen species-dependent routes" . "Nachin, L." . "Je\u017Eek, Petr" . .