. "Disruption of the Plasma Membrane Integrity by Cholesterol Depletion Impairs Effectiveness of TRH Receptor-Mediated Signal Transduction via Gq/G11 Proteins" . . "Osta\u0161ov, Pavel" . "Naru\u0161en\u00ED integrity plasmatick\u00E9 membr\u00E1ny zp\u016Fsoben\u00E9 odstran\u011Bn\u00EDm cholesterolu sni\u017Euje efektivitu p\u0159enosu sign\u00E1lu zprost\u0159edkovan\u00E9ho TRH receptory p\u0159es proteiny Gq/G11"@cs . "Disruption of the Plasma Membrane Integrity by Cholesterol Depletion Impairs Effectiveness of TRH Receptor-Mediated Signal Transduction via Gq/G11 Proteins"@en . . "417567" . . . "Novotn\u00FD, Ji\u0159\u00ED" . . "P(IAA500110606), P(LC06063), Z(AV0Z50110509)" . "Hejnov\u00E1, Lucie" . . "V t\u00E9to pr\u00E1ci jsme se zam\u011B\u0159ili na vlastnosti vazby radioligand\u016F thyrotropin-releasing hormone (TRH) receptor\u016F, funk\u010Dn\u00ED aktivitu Gq/11\u03B1 protein\u016F a funkciunalitu cel\u00E9 sign\u00E1ln\u00ED kask\u00E1dy a jejich zm\u011Bny po odstran\u011Bn\u00ED cholesterolu v bu\u0148k\u00E1ch HEK293 exprimuj\u00EDc\u00EDch vysok\u00E9 hladiny TRH receptor\u016F a G11\u03B1 proteinu.Na\u0161e v\u00FDsledky ukazuj\u00ED, \u017Ee intaktn\u00ED struktura membr\u00E1ny je velmi d\u016Fle\u017Eit\u00E1 pro optim\u00E1ln\u00ED p\u0159enos sign\u00E1lu z TRH receptor\u016F zprost\u0159edkovan\u00E9ho proteiny Gq/G11"@cs . . . "5-6" . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Bou\u0159ov\u00E1, Lenka" . . "In this study we monitored the radioligand-binding characteristics of thyrotropin-releasing hormone (TRH) receptors, functional activity of Gq/11\u03B1 proteins, and functional status of the whole signaling cascade and their changes after cholesterol depletion in HEK293 expressing high levels of TRH receptors and G11\u03B1. Our data suggest that the intact structure of plasma membranes is an important for optimum signal transduction initiated by TRH receptors and mediated by Gq/11\u03B1 proteins"@en . "Disruption of the Plasma Membrane Integrity by Cholesterol Depletion Impairs Effectiveness of TRH Receptor-Mediated Signal Transduction via Gq/G11 Proteins" . . . "TRH receptor; Gq/G11 protein; cholesterol"@en . "18"^^ . . "In this study we monitored the radioligand-binding characteristics of thyrotropin-releasing hormone (TRH) receptors, functional activity of Gq/11\u03B1 proteins, and functional status of the whole signaling cascade and their changes after cholesterol depletion in HEK293 expressing high levels of TRH receptors and G11\u03B1. Our data suggest that the intact structure of plasma membranes is an important for optimum signal transduction initiated by TRH receptors and mediated by Gq/11\u03B1 proteins" . "Disruption of the Plasma Membrane Integrity by Cholesterol Depletion Impairs Effectiveness of TRH Receptor-Mediated Signal Transduction via Gq/G11 Proteins"@en . "RIV/67985823:_____/07:00095553" . "5"^^ . "Journal of Receptors and Signal Transduction" . "1079-9893" . "Naru\u0161en\u00ED integrity plasmatick\u00E9 membr\u00E1ny zp\u016Fsoben\u00E9 odstran\u011Bn\u00EDm cholesterolu sni\u017Euje efektivitu p\u0159enosu sign\u00E1lu zprost\u0159edkovan\u00E9ho TRH receptory p\u0159es proteiny Gq/G11"@cs . "5"^^ . . . "27" . "RIV/67985823:_____/07:00095553!RIV08-AV0-67985823" . . . "Svoboda, Petr" . "[217C1004898E]" . . . "335;352" . .