"31" . . . "RIV/67985823:_____/06:00049130" . . "0364-3190" . "Activity of lactate dehydrogenase in serum and cerebral cortex of immature and mature rats after hypobaric hypoxia"@en . . . "C\u00EDlem pr\u00E1ce bylo ur\u010Dit, zda sn\u00ED\u017Een\u00ED lakt\u00E1tu v plazm\u011B vyvolan\u00E9 pod\u00E1n\u00EDm L-karnitinu bylo zp\u016Fsobeno modifikac\u00ED lakt\u00E1tdehydrogen\u00E1zy (LDH). LDH v mozku se zvy\u0161ovala s v\u011Bkem, av\u0161ak nebyla ovlivn\u011Bna hypobarickou hypoxi\u00ED ani pod\u00E1n\u00EDm L-karnitinu. Naproti tomu, s\u00E9rov\u00E1 LDH nevyk\u00E1zala v\u011Bkovou z\u00E1vislost. Vystaven\u00ED akutn\u00ED hypobarick\u00E9 hypoxii zv\u00FD\u0161ilo s\u00E9rovou LDH u 21-denn\u00EDch potkan\u016F. Pod\u00E1n\u00ED L-karnitinu potkan\u016Fm vystaven\u00FDm hypobarick\u00E9 hypoxii sn\u00ED\u017Eilo s\u00E9rovou LDH u 21- a 90-denn\u00EDch zv\u00ED\u0159at. Lze uzav\u0159\u00EDt, \u017Ee akutn\u00ED hypobarick\u00E1 hypoxie a/nebo L-karnitinov\u00E9 pod\u00E1n\u00ED modifikovaly s\u00E9rovou, ale ne mozkovou LDH"@cs . . "464090" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Rauchov\u00E1, Hana" . "brain; lactate dehydrogenase; hypoxia"@en . . "Koudelov\u00E1, J." . "RIV/67985823:_____/06:00049130!RIV07-AV0-67985823" . "Activity of lactate dehydrogenase in serum and cerebral cortex of immature and mature rats after hypobaric hypoxia" . "Activity of lactate dehydrogenase in serum and cerebral cortex of immature and mature rats after hypobaric hypoxia"@en . "[C2CF2A9647C6]" . "Aktivita lakt\u00E1tdehydrogen\u00E1zy v s\u00E9ru a mozkov\u00E9 k\u016F\u0159e nezral\u00FDch a zral\u00FDch krys po hypobarick\u00E9 hypoxii"@cs . . "The aim was to determine if the L-carnitine-dependent decrease of plasma lactate could be due to a modification of lactate dehydrogenase (LDH) activity. We found an increased of brain LDH activity with the age. However, we did not observe any significant differences in LDH activity after exposure to hypobaric hypoxia or L-carnitine pretreatment. In contrast to brain, serum LDH activity did not show any age-dependence. The hypoxia exposure increased LDH activity of 21-day-old rats only. Pretreatment of rats with L-carnitine decreased serum LDH activity of 21- and 90-day-old rats. In conclusion, acute hypobaric hypoxia and/or L-carnitine pretreatment modified serum but not brain LDH activity"@en . "Vokurkov\u00E1, Martina" . "915;919" . . "Neurochemical Research" . "Activity of lactate dehydrogenase in serum and cerebral cortex of immature and mature rats after hypobaric hypoxia" . . "2"^^ . "P(1M0510), P(GA305/04/0500), Z(AV0Z50110509)" . "7" . . "Aktivita lakt\u00E1tdehydrogen\u00E1zy v s\u00E9ru a mozkov\u00E9 k\u016F\u0159e nezral\u00FDch a zral\u00FDch krys po hypobarick\u00E9 hypoxii"@cs . . . "The aim was to determine if the L-carnitine-dependent decrease of plasma lactate could be due to a modification of lactate dehydrogenase (LDH) activity. We found an increased of brain LDH activity with the age. However, we did not observe any significant differences in LDH activity after exposure to hypobaric hypoxia or L-carnitine pretreatment. In contrast to brain, serum LDH activity did not show any age-dependence. The hypoxia exposure increased LDH activity of 21-day-old rats only. Pretreatment of rats with L-carnitine decreased serum LDH activity of 21- and 90-day-old rats. In conclusion, acute hypobaric hypoxia and/or L-carnitine pretreatment modified serum but not brain LDH activity" . "3"^^ . . "5"^^ . . . . .