"125" . "2"^^ . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . . "The aim of this study was to evaluate the role of TRPV1 receptor-containing nociceptors in the development of post-operative allodynia and hyperalgesia by their functional inactivation using a high-concentration intradermal injection of capsaicin in a rat plantar incision model. Paw withdrawal responses to mechanical and thermal stimuli applied on plantar skin were tested in animals treated with capsaicin or the vehicle. Our results show an important role of TRPV1-containing nociceptors in the development of post-surgical hypersensitivity and suggest that local, high-concentration capsaicin treatment could be used to reduce it"@en . . "Post-operative pain behavior in rats is reduced after single high-concentration capsaicin application" . . "2"^^ . "11"^^ . "P(GA305/06/1115), P(GA309/03/0752), P(GD305/03/H148), P(LC554), Z(AV0Z50110509)" . "The aim of this study was to evaluate the role of TRPV1 receptor-containing nociceptors in the development of post-operative allodynia and hyperalgesia by their functional inactivation using a high-concentration intradermal injection of capsaicin in a rat plantar incision model. Paw withdrawal responses to mechanical and thermal stimuli applied on plantar skin were tested in animals treated with capsaicin or the vehicle. Our results show an important role of TRPV1-containing nociceptors in the development of post-surgical hypersensitivity and suggest that local, high-concentration capsaicin treatment could be used to reduce it" . "Post-operative pain behavior in rats is reduced after single high-concentration capsaicin application"@en . . . "Poopera\u010Dn\u00ED bolest je sn\u00ED\u017Eena po jednor\u00E1zov\u00E9 aplikaci capsaicinu o vysok\u00E9 koncentraci u krys"@cs . "Posp\u00ED\u0161ilov\u00E1, Eva" . "493318" . . . "\u00DA\u010Delem t\u00E9to studie bylo zhodnotit \u00FAlohu TRPV1-exprimuj\u00EDc\u00EDch nociceptor\u016F v rozvoji poopera\u010Dn\u00ED allodynie a hyperalgesie jejich funk\u010Dn\u00ED inaktivac\u00ED pomoc\u00ED intraderm\u00E1ln\u00ED injekce capsaicinu ve vysok\u00E9 koncentraci na krys\u00EDm modelu plant\u00E1rn\u00ED incise. Byly testov\u00E1ny reflexn\u00ED odpov\u011Bdi na mechanick\u00E9 a tepeln\u00E9 podn\u011Bty aplikovan\u00E9 na k\u016F\u017Ei planty pedis zv\u00ED\u0159at ovlivn\u011Bn\u00FDch bu\u010F capsaicinem nebo jen rozpou\u0161t\u011Bdlem. Na\u0161e v\u00FDsledky prok\u00E1zaly v\u00FDznamnou \u00FAlohu TRPV1-exprimuj\u00EDc\u00EDch nociceptor\u016F v rozvoji poopera\u010Dn\u00ED hypersensitivity a poukazuj\u00ED na mo\u017Enost vyu\u017Eit\u00ED lok\u00E1ln\u011B aplikovan\u00E9ho capsaicinu ve vysok\u00E9 koncentraci k jej\u00EDmu ovlivn\u011Bn\u00ED"@cs . . . . "[DCACFDB4F39D]" . . . "Post-operative pain behavior in rats is reduced after single high-concentration capsaicin application"@en . "3" . . . "Pale\u010Dek, Ji\u0159\u00ED" . "Poopera\u010Dn\u00ED bolest je sn\u00ED\u017Eena po jednor\u00E1zov\u00E9 aplikaci capsaicinu o vysok\u00E9 koncentraci u krys"@cs . . . "0304-3959" . . "RIV/67985823:_____/06:00044589" . . "capsaicin; TRPV1; surgical pain"@en . . "233;243" . . "Post-operative pain behavior in rats is reduced after single high-concentration capsaicin application" . "Pain" . "RIV/67985823:_____/06:00044589!RIV07-AV0-67985823" .