. "Blok\u00E1da muskarinov\u00FDch receptor\u016F skopolaminem se pou\u017E\u00EDv\u00E1 jako model poruch pam\u011Bti ve st\u00E1\u0159\u00ED. V p\u0159edkl\u00E1dan\u00E9 studii jsme si polo\u017Eili ot\u00E1zku, jak\u00FD bude m\u00EDt tato blok\u00E1da vliv na prostorovou orientaci u potkan\u016F. Zjistili jsme, \u017Ee aplikace skopolaminu vede k naru\u0161en\u00ED orientace ve v\u00FD\u0161e zm\u00EDn\u011Bn\u00E9 \u00FAloze, a\u010Dkoliv d\u00E1vky pot\u0159ebn\u00E9 k t\u00E9to blok\u00E1d\u011B byly o n\u011Bco vy\u0161\u0161\u00ED ne\u017E v p\u0159ede\u0161l\u00FDch studi\u00EDch jin\u00FDch autor\u016F"@cs . "In the present study we addressed whether navigation in the Active Allothetic Place Avoidance (AAPA) task, which requires animals to separate spatial stimuli into coherent representations and to navigate according to the representation relevant for the task, is dependent on intact muscarinic receptors in the brain. We studied the effect of three doses of scopolamine (0.5mg/kg, 1.0mg/kg and 2.0mg/kg) administered 20 min prior to training on the retention of the AAPA and re-acquisition of the AAPA in a new environment. The dose of 2.0 mg/kg was found to impair both AAPA retention and re-acquisition of the AAPA in a new environment, whereas the 1.0 mg/kg dose only impaired the reinforced retention of AAPA. It is concluded that, unlike navigation in classic paradigms, efficient orientation in the AAPA task is critically dependent on muscarinic receptors in the brain"@en . "Vale\u0161, Karel" . "NL - Nizozemsko" . . "RIV/67985823:_____/05:00000814!RIV06-AV0-67985823" . "2"^^ . "In the present study we addressed whether navigation in the Active Allothetic Place Avoidance (AAPA) task, which requires animals to separate spatial stimuli into coherent representations and to navigate according to the representation relevant for the task, is dependent on intact muscarinic receptors in the brain. We studied the effect of three doses of scopolamine (0.5mg/kg, 1.0mg/kg and 2.0mg/kg) administered 20 min prior to training on the retention of the AAPA and re-acquisition of the AAPA in a new environment. The dose of 2.0 mg/kg was found to impair both AAPA retention and re-acquisition of the AAPA in a new environment, whereas the 1.0 mg/kg dose only impaired the reinforced retention of AAPA. It is concluded that, unlike navigation in classic paradigms, efficient orientation in the AAPA task is critically dependent on muscarinic receptors in the brain" . . "Central muscarinic blockade interferes with retrieval and reacquisition of active allothetic place avoidance despite spatial pretraining"@en . . "P(1M0517), P(GP309/03/P126), Z(AV0Z50110509)" . . "2"^^ . "Behavioural Brain Research" . "7"^^ . . "0166-4328" . "RIV/67985823:_____/05:00000814" . . . . "Centr\u00E1ln\u00ED muskarinov\u00E1 blok\u00E1da po\u0161kozuje vybaven\u00ED a znovunau\u010Den\u00ED aktivn\u00EDho alotetick\u00E9ho vyh\u00FDb\u00E1n\u00ED se m\u00EDstu bez ohledu na intaktn\u00ED p\u0159edtr\u00E9nov\u00E1n\u00ED"@cs . . "[E3A423D5EA33]" . . . "place navigation; cognition; scopolamine"@en . . "514634" . . . . "238;244" . "Centr\u00E1ln\u00ED muskarinov\u00E1 blok\u00E1da po\u0161kozuje vybaven\u00ED a znovunau\u010Den\u00ED aktivn\u00EDho alotetick\u00E9ho vyh\u00FDb\u00E1n\u00ED se m\u00EDstu bez ohledu na intaktn\u00ED p\u0159edtr\u00E9nov\u00E1n\u00ED"@cs . . . "Central muscarinic blockade interferes with retrieval and reacquisition of active allothetic place avoidance despite spatial pretraining"@en . "Central muscarinic blockade interferes with retrieval and reacquisition of active allothetic place avoidance despite spatial pretraining" . "2" . "Stuchl\u00EDk, Ale\u0161" . "161" . . "Central muscarinic blockade interferes with retrieval and reacquisition of active allothetic place avoidance despite spatial pretraining" .