. "10" . . . "10"^^ . . "Hofbauerov\u00E1, Kate\u0159ina" . "383" . . . . "With respect to the mechanism of chaperone-like activity, we examined the behaviour of haptoglobin under heat shock conditions. Secondary structure changes during heat treatment were followed by circular dichroism, Raman spectroscopy and infrared spectroscopy. A model of the haptoglobin tetramer, based on its sequence homology with serine proteases and the CCP modules, has been proposed. Sequence regions responsible for the chaperone-like activity were not fully identical with the region that took part in formation of the hemoglobin-haptoglobin complex. We can postulate presence of at least two different chaperone-binding sites on each haptoglobin heavy chain." . "Study of chaperone-like activity of human haptoglobin: conformational changes under heat shock conditions and localization of interaction sites."@en . . "1431-6730" . "Study of chaperone-like activity of human haptoglobin: conformational changes under heat shock conditions and localization of interaction sites." . "RIV/67985823:_____/02:20030020" . "Study of chaperone-like activity of human haptoglobin: conformational changes under heat shock conditions and localization of interaction sites." . "Ettrich, R." . "Brandt, W." . "RIV/67985823:_____/02:20030020!RIV/2004/AV0/A20004/N" . . . . "Pavl\u00ED\u010Dek, Z." . "1"^^ . "chaperone; haptoglobin; molecular modeling"@en . "With respect to the mechanism of chaperone-like activity, we examined the behaviour of haptoglobin under heat shock conditions. Secondary structure changes during heat treatment were followed by circular dichroism, Raman spectroscopy and infrared spectroscopy. A model of the haptoglobin tetramer, based on its sequence homology with serine proteases and the CCP modules, has been proposed. Sequence regions responsible for the chaperone-like activity were not fully identical with the region that took part in formation of the hemoglobin-haptoglobin complex. We can postulate presence of at least two different chaperone-binding sites on each haptoglobin heavy chain."@en . "1667;1676" . . "Kopeck\u00FD jr., V." . "0"^^ . "0"^^ . "[839934B23E81]" . . "Biological Chemistry" . . "Study of chaperone-like activity of human haptoglobin: conformational changes under heat shock conditions and localization of interaction sites."@en . "6"^^ . . "Baumruk, V." . . "665699" . "Z(AV0Z5011922), Z(MSM 113100001)" . "DE - Spolkov\u00E1 republika N\u011Bmecko" .