. "Renal ischemia-reperfusion injury in the rat is prevented by a novel immune modulation therapy"@en . "Chen, H." . "662094" . "RIV/67985823:_____/02:00142385" . . . . . "Z(AV0Z5011922)" . "12"^^ . "1425;1433" . "Vasogen Inc.'s immune modulation therapy (IMT) is a therapy in which cells from the patient's own blood are modified by ex vivo exposure to specific physicochemical stressors, including oxidation, ultraviolet (UV) light, and an elevated temperature. This study tested the hypothesis that IMT can prevent renal ischemia-reperfusion (I/R) injury in rats. IMT pretreatment of SHR significantly reduced renal I/R injury compared with equivalent placebo treatments consisting of untreated blood- or saline-injected SHR, as evidenced by a significant increase of the survival rate curves in young and old male SHR, which correlated with 24-hour postischemic diuresis. Our data demonstrate that IMT prevents the destruction of kidney tissue and the resulting animal death caused by renal I/R injury"@en . "Imunitn\u00ED modula\u010Dn\u00ED terapie (IMT) firmy Vasogen je terapie, p\u0159i kter\u00E9 jsou krevn\u00ED bu\u0148ky pacienta modifikov\u00E1ny ex vivo pomoc\u00ED fyzikochemick\u00FDch stresor\u016F zahrnuj\u00EDc\u00EDch oxidaci, UV z\u00E1\u0159en\u00ED a zv\u00FD\u0161enou teplotu. Studie testovala hypot\u00E9zu, \u017Ee IMT m\u016F\u017Ee zabr\u00E1nit ischemicko-reperfuzn\u00EDmu (I/R) po\u0161kozen\u00ED ledvin u potkan\u016F. Aplikace metody u SHR potkan\u016F v\u00FDznamn\u011B sn\u00ED\u017Eila I/R po\u0161kozen\u00ED v porovn\u00E1n\u00ED se zv\u00ED\u0159aty u nich\u017E byla pod\u00E1na neupraven\u00E1 krev a nebo fyziologick\u00FD roztok. To bylo evidentn\u00ED na zv\u00FD\u0161en\u00ED p\u0159e\u017E\u00EDv\u00E1n\u00ED u mlad\u00FDch i dosp\u011Bl\u00FDch SHR potkan\u016F, co\u017E korelovalo s 24 hod. diur\u00E9zou. Na\u0161e v\u00FDsledky uk\u00E1zaly, \u017Ee IMT zabr\u00E1n\u00ED destrukci ledvinn\u00E9 tk\u00E1n\u011B a t\u00EDm sn\u00ED\u017E\u00ED \u00FAmrtnost na I/R po\u0161kozen\u00ED ledvin"@cs . "9"^^ . "Der Sarkissian, S." . "Hamet, P." . "deBlois, D." . "10" . . "Gaboury, L." . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Renal ischemia-reperfusion injury in the rat is prevented by a novel immune modulation therapy" . . "Ren\u00E1ln\u00EDmu ischemickoreperfuzn\u00ED po\u0161kozen\u00ED m\u016F\u017Ee b\u00FDt zabr\u00E1n\u011Bno novou imunomodula\u010Dn\u00ED terapi\u00ED"@cs . "Transplantation Bulletin" . . "renal ischemia; immune therapy; rat"@en . "Renal ischemia-reperfusion injury in the rat is prevented by a novel immune modulation therapy" . "Peng, J." . "Gouadon, E." . . "Bolton, A. E." . . "Vasogen Inc.'s immune modulation therapy (IMT) is a therapy in which cells from the patient's own blood are modified by ex vivo exposure to specific physicochemical stressors, including oxidation, ultraviolet (UV) light, and an elevated temperature. This study tested the hypothesis that IMT can prevent renal ischemia-reperfusion (I/R) injury in rats. IMT pretreatment of SHR significantly reduced renal I/R injury compared with equivalent placebo treatments consisting of untreated blood- or saline-injected SHR, as evidenced by a significant increase of the survival rate curves in young and old male SHR, which correlated with 24-hour postischemic diuresis. Our data demonstrate that IMT prevents the destruction of kidney tissue and the resulting animal death caused by renal I/R injury" . "RIV/67985823:_____/02:00142385!RIV07-AV0-67985823" . "0041-1337" . . . "Marshansky, V." . "Renal ischemia-reperfusion injury in the rat is prevented by a novel immune modulation therapy"@en . . . "Kune\u0161, Jaroslav" . "[46FA1F38358A]" . "Ren\u00E1ln\u00EDmu ischemickoreperfuzn\u00ED po\u0161kozen\u00ED m\u016F\u017Ee b\u00FDt zabr\u00E1n\u011Bno novou imunomodula\u010Dn\u00ED terapi\u00ED"@cs . "74" . "Vu, M. D." . "Tremblay, J." . "1"^^ .