. "5"^^ . . "\u0158e\u0161en\u00ED popisuje zp\u016Fsob identifikace osob se zv\u00FD\u0161en\u00FDm genetick\u00FDm rizikem v\u00FDskytu akutn\u00EDho infarktu myokardu, se z\u0159etelem k p\u0159\u00EDpadn\u00FDm fat\u00E1ln\u00EDm n\u00E1sledk\u016Fm v d\u016Fsledku kardiovaskul\u00E1rn\u00EDch komplikac\u00ED v \u010Dasov\u00E9m horizontu do 6 m\u011Bs\u00EDc\u016F od okam\u017Eiku v\u00FDskytu srde\u010Dn\u00ED p\u0159\u00EDhody, spo\u010D\u00EDvaj\u00EDc\u00ED v tom, \u017Ee se v biologick\u00E9m vzorku odebran\u00E9m z t\u011Bla pacienta stanov\u00ED intenzita exprese gen\u016F a genetick\u00FDch lokus\u016F ECHDC3, IL18RAP, PFKFB2, IRS2, PHACTR1, ERLIN1, VNN3, ADORA3, CLEC4E, ASPRV1, PFKFB2, CPD, FKBP5, PRKDC, NPM1 a SAMSN1. Logaritmovan\u00E1 hodnota intenzity exprese p\u0159i z\u00E1kladu 2 se n\u00E1sledn\u011B srovn\u00E1 s referen\u010Dn\u00ED hodnotou intenzity exprese, p\u0159i\u010Dem\u017E odchylka od referen\u010Dn\u00ED hodnoty rovn\u00E1 alespo\u0148 minim\u00E1ln\u00ED odchylce u v\u0161ech uveden\u00FDch gen\u016F a genetick\u00FDch lokus\u016F zna\u010D\u00ED zv\u00FD\u0161en\u00E9 riziko." . . . . . . "RIV/67985807:_____/12:00382024!RIV13-AV0-67985807" . . . "Gr\u00FCnfeldov\u00E1, H." . . . "182935" . "Method of identifying persons with increased genetic risk of myocardial infarction occurrence"@en . "P(1M06014), Z(AV0Z10300504)" . "akutn\u00ED infarkt myokardu; genov\u00E1 exprese; genetick\u00E9 riziko"@en . . "Prague" . "Valenta, Zden\u011Bk" . . . "Zp\u016Fsob identifikace osob se zv\u00FD\u0161en\u00FDm genetick\u00FDm rizikem v\u00FDskytu infarktu myokardu"@cs . "http://isdv.upv.cz/portal/pls/portal/portlets.pts.det?xprim=1631631&lan=cs" . . "Zp\u016Fsob identifikace osob se zv\u00FD\u0161en\u00FDm genetick\u00FDm rizikem v\u00FDskytu infarktu myokardu"@cs . "\u00DA\u0159ad pr\u016Fmyslov\u00E9ho vlastnictv\u00ED" . . "Zv\u00E1rov\u00E1, Jana" . "\u0158e\u0161en\u00ED popisuje zp\u016Fsob identifikace osob se zv\u00FD\u0161en\u00FDm genetick\u00FDm rizikem v\u00FDskytu akutn\u00EDho infarktu myokardu, se z\u0159etelem k p\u0159\u00EDpadn\u00FDm fat\u00E1ln\u00EDm n\u00E1sledk\u016Fm v d\u016Fsledku kardiovaskul\u00E1rn\u00EDch komplikac\u00ED v \u010Dasov\u00E9m horizontu do 6 m\u011Bs\u00EDc\u016F od okam\u017Eiku v\u00FDskytu srde\u010Dn\u00ED p\u0159\u00EDhody, spo\u010D\u00EDvaj\u00EDc\u00ED v tom, \u017Ee se v biologick\u00E9m vzorku odebran\u00E9m z t\u011Bla pacienta stanov\u00ED intenzita exprese gen\u016F a genetick\u00FDch lokus\u016F ECHDC3, IL18RAP, PFKFB2, IRS2, PHACTR1, ERLIN1, VNN3, ADORA3, CLEC4E, ASPRV1, PFKFB2, CPD, FKBP5, PRKDC, NPM1 a SAMSN1. Logaritmovan\u00E1 hodnota intenzity exprese p\u0159i z\u00E1kladu 2 se n\u00E1sledn\u011B srovn\u00E1 s referen\u010Dn\u00ED hodnotou intenzity exprese, p\u0159i\u010Dem\u017E odchylka od referen\u010Dn\u00ED hodnoty rovn\u00E1 alespo\u0148 minim\u00E1ln\u00ED odchylce u v\u0161ech uveden\u00FDch gen\u016F a genetick\u00FDch lokus\u016F zna\u010D\u00ED zv\u00FD\u0161en\u00E9 riziko."@cs . . "Zp\u016Fsob identifikace osob se zv\u00FD\u0161en\u00FDm genetick\u00FDm rizikem v\u00FDskytu infarktu myokardu" . "Method of identifying persons with increased genetic risk of myocardial infarction occurrence"@en . "[C835947B215D]" . . "303378" . . . . "4"^^ . . . . "In the present invention, there is described a method of identifying persons with increased genetic risk of acute myocardial infarction occurrence with regard to optional fatal consequences due to cardiovascular complications within a time horizon up to 6 months from the instant of a heart event occurrence wherein the method is characterized in that intensity of gene expression and occurrence of genetic loci selected from a group consisting ECHDC3, IL18RAP, PFKFB2, IRS2, PHACTR1, ERLIN1, VNN3, ADORA3, CLEC4E, ASPRV1, PFKFB2, CPD, FKBP5, PRKDC, NPM1 and SAMSN1 is determined from a biologic sample taken from patients body. Subsequently, logarithmic value of expression intensity at a base of 2 is compared with the reference value of the expression intensity, whereby a deviation from the reference value equal to at least a minimum deviation in all the indicated genes and genetic loci represents the increased risk."@en . . "Zp\u016Fsob identifikace osob se zv\u00FD\u0161en\u00FDm genetick\u00FDm rizikem v\u00FDskytu infarktu myokardu" . "Feglarov\u00E1, Petra" . "2012-07-11+02:00"^^ . "RIV/67985807:_____/12:00382024" . "\u00DAstav informatiky AV \u010CR, v. v. i. Centrum biomedic\u00EDnsk\u00E9 informatiky" . . . "Mazura, Ivan" .