. . "sarcoma"@en . . "Recent advances in treatment of bone sarcomas"@en . . "1802-4475" . . "Pokroky ve farmakoterapii kostn\u00EDch sarkom\u016F"@cs . "6" . "I p\u0159es radik\u00E1ln\u00ED chirurgick\u00E9 v\u00FDkony historicky dlouhodob\u011B p\u0159e\u017E\u00EDvalo pouze 15\u201320 % pacient\u016F s prim\u00E1rn\u00EDm kostn\u00EDm sarkomem. Z\u00E1sadn\u00ED zlep\u0161en\u00ED v progn\u00F3ze onemocn\u011Bn\u00ED p\u0159ineslo za\u0159azen\u00ED syst\u00E9mov\u00E9 chemoterapie v sedmdes\u00E1t\u00FDch a osmdes\u00E1t\u00FDch letech, kdy se ji\u017E da\u0159ilo dosahovat dlouhodob\u00FDch remis\u00ED u 60\u201370 % pacient\u016F s lokalizovan\u00FDm onemocn\u011Bn\u00EDm. V posledn\u00EDch dvaceti letech se v\u0161ak nad\u011Bje nemocn\u00FDch na vyl\u00E9\u010Den\u00ED p\u0159\u00EDli\u0161 nezv\u00FD\u0161ila. C\u00EDlen\u00E1 terapie, event. metronomick\u00E1 l\u00E9\u010Dba, jsou jednou z mo\u017En\u00FDch cest, kterou lze d\u00E1t \u0161anci na p\u0159e\u017Eit\u00ED pacient\u016Fm s relapsy nebo rezistentn\u00EDmi n\u00E1dory, anebo sn\u00ED\u017Eit toxicitu konven\u010Dn\u00ED l\u00E9\u010Dby. V \u010Dl\u00E1nku je souhrnn\u011B pops\u00E1n stav v\u00FDzkumu nov\u00FDch l\u00E9\u010Debn\u00FDch mo\u017Enost\u00ED u sarkom\u016F skeletu. V\u011Bt\u0161ina l\u00E9k\u016F je ve f\u00E1zi 1. a 2. klinick\u00E9ho zkou\u0161en\u00ED. Samostatn\u011B je pojedn\u00E1no o l\u00E9\u010Db\u011B obrovskobun\u011B\u010Dn\u00E9ho kostn\u00EDho n\u00E1doru." . "I, V" . . . "K\u00FAtnikov\u00E1, Lucia" . "M\u00FAdry, Peter" . "Pokroky ve farmakoterapii kostn\u00EDch sarkom\u016F" . . . "I p\u0159es radik\u00E1ln\u00ED chirurgick\u00E9 v\u00FDkony historicky dlouhodob\u011B p\u0159e\u017E\u00EDvalo pouze 15\u201320 % pacient\u016F s prim\u00E1rn\u00EDm kostn\u00EDm sarkomem. Z\u00E1sadn\u00ED zlep\u0161en\u00ED v progn\u00F3ze onemocn\u011Bn\u00ED p\u0159ineslo za\u0159azen\u00ED syst\u00E9mov\u00E9 chemoterapie v sedmdes\u00E1t\u00FDch a osmdes\u00E1t\u00FDch letech, kdy se ji\u017E da\u0159ilo dosahovat dlouhodob\u00FDch remis\u00ED u 60\u201370 % pacient\u016F s lokalizovan\u00FDm onemocn\u011Bn\u00EDm. V posledn\u00EDch dvaceti letech se v\u0161ak nad\u011Bje nemocn\u00FDch na vyl\u00E9\u010Den\u00ED p\u0159\u00EDli\u0161 nezv\u00FD\u0161ila. C\u00EDlen\u00E1 terapie, event. metronomick\u00E1 l\u00E9\u010Dba, jsou jednou z mo\u017En\u00FDch cest, kterou lze d\u00E1t \u0161anci na p\u0159e\u017Eit\u00ED pacient\u016Fm s relapsy nebo rezistentn\u00EDmi n\u00E1dory, anebo sn\u00ED\u017Eit toxicitu konven\u010Dn\u00ED l\u00E9\u010Dby. V \u010Dl\u00E1nku je souhrnn\u011B pops\u00E1n stav v\u00FDzkumu nov\u00FDch l\u00E9\u010Debn\u00FDch mo\u017Enost\u00ED u sarkom\u016F skeletu. V\u011Bt\u0161ina l\u00E9k\u016F je ve f\u00E1zi 1. a 2. klinick\u00E9ho zkou\u0161en\u00ED. Samostatn\u011B je pojedn\u00E1no o l\u00E9\u010Db\u011B obrovskobun\u011B\u010Dn\u00E9ho kostn\u00EDho n\u00E1doru."@cs . "4" . "RIV/65269705:_____/12:#0001879!RIV13-MZ0-65269705" . "Pokroky ve farmakoterapii kostn\u00EDch sarkom\u016F"@cs . "3"^^ . "Onkologie" . "CZ - \u010Cesk\u00E1 republika" . . . "Zapletalov\u00E1, Danica" . "Pokroky ve farmakoterapii kostn\u00EDch sarkom\u016F" . "3"^^ . . "[5DE764AAF45F]" . "3"^^ . "RIV/65269705:_____/12:#0001879" . . "Recent advances in treatment of bone sarcomas"@en . "At present, therapy success in bone sarcoma is significantly better compared to historical cohorts, with 60\u201370 % overall survival. Unfortunately, no sufficient progress in better survival of patients with relapsed and refractory bone sarcomas during last twenty years has been observed. Here we review targeted therapeutics in bone sarcomas being under investigation that may bring chance to patients suffering from relapsed and chemoresistant bone sarcomas. A majority of the targeted drugs are given as part of phase 1 or 2 studies. Separately, recent successful findings of efficacy of denosumab in treatment of giant bone cell tumor are described."@en . "159371" . . . .