. . . "V\u00FDznam biomarker\u016F NGAL a cystatin\u016F C u kardiovaskul\u00E1rn\u00EDch onemocn\u011Bn\u00ED" . "Cystatin C je inhibitor lyzozom\u00E1ln\u00EDch prote\u00E1z a extracelul\u00E1rn\u00EDch cysteinov\u00FDch prote\u00E1z, pod\u00EDl\u00ED na regulaci metabolizmu extra\u00ADcelul\u00E1rn\u00EDch protein\u016F. Je pln\u011B filtrovateln\u00FD glomerulem a zcela se vst\u0159eb\u00E1v\u00E1 a katabolizuje bu\u0148kami proxim\u00E1ln\u00EDho tubulu ledvin. NGAL (Neutrophil gelatinase-associated lipocalin) je protein akutn\u00ED f\u00E1ze, pod\u00EDl\u00ED se na antibakteri\u00E1ln\u00ED imunit\u011B a jeho d\u016Fle\u017Eitou vlastnost\u00ED je tvorba komplexu s matrix metaloprote\u00E1zou 9 (MMP-9), \u010D\u00EDm\u017E zvy\u0161uje jej\u00ED aktivitu a br\u00E1n\u00ED jej\u00ED degradaci. NGAL je voln\u011B filtrov\u00E1n p\u0159es glomerul\u00E1rn\u00ED membr\u00E1nu a v proxim\u00E1ln\u00EDm tubulu ledvin je reabsorbov\u00E1n endocyt\u00F3zou. NGAL detekovan\u00FD v mo\u010Di je produkov\u00E1n zejm\u00E9na v dist\u00E1ln\u00EDm nefronu. Podle s\u00E9rov\u00E9 hladiny cystatinu C a NGAL je mo\u017En\u00E9 diagnostikovat akutn\u00ED po\u0161kozen\u00ED ledvin o 1,5\u20132 dny d\u0159\u00EDve ne\u017E p\u0159i monitoraci funkce ledvin podle s\u00E9rov\u00E9 hladiny kreatininu. Ve srovn\u00E1n\u00ED s informacemi, kter\u00E9 poskytuje kreatinin nebo odhadovan\u00E1 GFR, zv\u00FD\u0161en\u00ED hladiny cystatinu C p\u0159in\u00E1\u0161\u00ED u pacient\u016F s kardiovaskul\u00E1rn\u00EDm onemocn\u011Bn\u00EDm nav\u00EDc informaci o progn\u00F3ze t\u011Bchto pacient\u016F. Zv\u00FD\u0161en\u00E1 hladina NGAL byla detekov\u00E1na u pacient\u016F s akutn\u00EDm infarktem myokardu, srde\u010Dn\u00EDm selh\u00E1n\u00EDm nebo po c\u00E9vn\u00ED mozkov\u00E9 p\u0159\u00EDhod\u011B. O prognostick\u00E9m v\u00FD\u00ADznamu NGAL u pacient\u016F po infarktu myokardu nebo se srde\u010Dn\u00EDm selh\u00E1n\u00EDm je zat\u00EDm minimum dat, rovn\u011B\u017E chyb\u00ED jejich srovn\u00E1n\u00ED navz\u00E1jem a porovn\u00E1n\u00ED s b\u011B\u017En\u011B stanovovan\u00FDmi natriuretick\u00FDmi peptidy"@cs . "Gottwaldov\u00E1, Jana" . "7"^^ . "V\u00FDznam biomarker\u016F NGAL a cystatin\u016F C u kardiovaskul\u00E1rn\u00EDch onemocn\u011Bn\u00ED" . . "[91BA7037BB02]" . "The importance of NGAL and cystatin C biomarkers in cardiovascular diseases"@en . "V\u00FDznam biomarker\u016F NGAL a cystatin\u016F C u kardiovaskul\u00E1rn\u00EDch onemocn\u011Bn\u00ED"@cs . "Pa\u0159enica, Ji\u0159\u00ED" . "RIV/65269705:_____/12:#0001797" . "Hel\u00E1nov\u00E1, Kate\u0159ina" . "Cystatin C is an inhibitor of lysosomal proteases and extracellular cysteine protease, it participates in the regulation of me\u00ADtabolism of extracellular proteins. It is fully glomerular filterable, completely absorbed and catabolised in proximal tubule cells. NGAL (neutrophil gelatinase-associated lipocalin) is an acute phase protein, participating in antibacterial immunity and his important feature is the formation of complex with metalloproteinase 9 (MMP-9), thereby increasing its activity and prevents its degradation. NGAL is freely filtered across the glomerular membrane and is reabsorbed by endocytosis in the proximal tubule. NGAL detected in urine is produced mainly in the distal nephron. The serum cystatin C and NGAL can diagnose acute renal impairment one or two days earlier in the com\u00ADparison with the monitoring of renal function by serum creatinine. Moreover, compared with the information provided by creatinine or by estimated GFR, the elevated cystatin C gives, in patients with cardiovascular disease, information about worse prognosis. Increased level of NGAL was detected in patients with acute myocardial infarction, heart failure or stroke. There is a lack of data about the prognostic significance of NGAL in patients after myocardial infarction or heart failure, no data about their comparison or interaction with natriu\u00ADretic peptides exists up today."@en . "58" . "V, Z(MSM0021622402)" . . . . . . . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" . "RIV/65269705:_____/12:#0001797!RIV13-MZ0-65269705" . "4" . "CZ - \u010Cesk\u00E1 republika" . . "\u010Cerm\u00E1kov\u00E1, Zdenka" . "Cystatin C je inhibitor lyzozom\u00E1ln\u00EDch prote\u00E1z a extracelul\u00E1rn\u00EDch cysteinov\u00FDch prote\u00E1z, pod\u00EDl\u00ED na regulaci metabolizmu extra\u00ADcelul\u00E1rn\u00EDch protein\u016F. Je pln\u011B filtrovateln\u00FD glomerulem a zcela se vst\u0159eb\u00E1v\u00E1 a katabolizuje bu\u0148kami proxim\u00E1ln\u00EDho tubulu ledvin. NGAL (Neutrophil gelatinase-associated lipocalin) je protein akutn\u00ED f\u00E1ze, pod\u00EDl\u00ED se na antibakteri\u00E1ln\u00ED imunit\u011B a jeho d\u016Fle\u017Eitou vlastnost\u00ED je tvorba komplexu s matrix metaloprote\u00E1zou 9 (MMP-9), \u010D\u00EDm\u017E zvy\u0161uje jej\u00ED aktivitu a br\u00E1n\u00ED jej\u00ED degradaci. NGAL je voln\u011B filtrov\u00E1n p\u0159es glomerul\u00E1rn\u00ED membr\u00E1nu a v proxim\u00E1ln\u00EDm tubulu ledvin je reabsorbov\u00E1n endocyt\u00F3zou. NGAL detekovan\u00FD v mo\u010Di je produkov\u00E1n zejm\u00E9na v dist\u00E1ln\u00EDm nefronu. Podle s\u00E9rov\u00E9 hladiny cystatinu C a NGAL je mo\u017En\u00E9 diagnostikovat akutn\u00ED po\u0161kozen\u00ED ledvin o 1,5\u20132 dny d\u0159\u00EDve ne\u017E p\u0159i monitoraci funkce ledvin podle s\u00E9rov\u00E9 hladiny kreatininu. Ve srovn\u00E1n\u00ED s informacemi, kter\u00E9 poskytuje kreatinin nebo odhadovan\u00E1 GFR, zv\u00FD\u0161en\u00ED hladiny cystatinu C p\u0159in\u00E1\u0161\u00ED u pacient\u016F s kardiovaskul\u00E1rn\u00EDm onemocn\u011Bn\u00EDm nav\u00EDc informaci o progn\u00F3ze t\u011Bchto pacient\u016F. Zv\u00FD\u0161en\u00E1 hladina NGAL byla detekov\u00E1na u pacient\u016F s akutn\u00EDm infarktem myokardu, srde\u010Dn\u00EDm selh\u00E1n\u00EDm nebo po c\u00E9vn\u00ED mozkov\u00E9 p\u0159\u00EDhod\u011B. O prognostick\u00E9m v\u00FD\u00ADznamu NGAL u pacient\u016F po infarktu myokardu nebo se srde\u010Dn\u00EDm selh\u00E1n\u00EDm je zat\u00EDm minimum dat, rovn\u011B\u017E chyb\u00ED jejich srovn\u00E1n\u00ED navz\u00E1jem a porovn\u00E1n\u00ED s b\u011B\u017En\u011B stanovovan\u00FDmi natriuretick\u00FDmi peptidy" . "cystatin C"@en . "5"^^ . . . . . "V\u00FDznam biomarker\u016F NGAL a cystatin\u016F C u kardiovaskul\u00E1rn\u00EDch onemocn\u011Bn\u00ED"@cs . . . . "180170" . "0042-773X" . "\u0160pinar, Jind\u0159ich" . . "The importance of NGAL and cystatin C biomarkers in cardiovascular diseases"@en . "5"^^ .