. "[7B7FB4A834F4]" . "1210-7859" . . "Amisulpride in the Treatment od Schizophrenia"@en . . "1"^^ . "000297401500014" . "CZ - \u010Cesk\u00E1 republika" . "Amisulprid v l\u00E9\u010Db\u011B schizofrenie" . "Amisulprid je antipsychotikum druh\u00E9 generace p\u016Fsob\u00EDc\u00ED jako antagonista dopaminov\u00FDch D2/\u2028/D3 receptor\u016F. \u00DA\u010Dinkuje tzv. bif\u00E1zicky \u2013 v\u00A0n\u00EDzk\u00FDch d\u00E1vk\u00E1ch zp\u016Fsobuje zv\u00FD\u0161en\u00ED dopaminov\u00E9 neurotransmise, ve vy\u0161\u0161\u00EDch d\u00E1vk\u00E1ch naopak jej\u00ED sn\u00ED\u017Een\u00ED. Osv\u011Bd\u010Dil se nejen v\u00A0l\u00E9\u010Db\u011B pozitivn\u00EDch p\u0159\u00EDznak\u016F schizofrenie, ale p\u0159\u00EDzniv\u011B p\u016Fsob\u00ED i\u00A0na negativn\u00ED a\u00A0patrn\u011B tak\u00E9 na afektivn\u00ED (depresivn\u00ED) p\u0159\u00EDznaky a\u00A0kognitivn\u00ED dysfunkci. Efektivn\u00ED je v\u00A0monoterapii, av\u0161ak existuj\u00ED i\u00A0d\u016Fkazy, \u017Ee m\u016F\u017Ee b\u00FDt \u00FA\u010Dinn\u00FD t\u00E9\u017E v\u00A0kombinac\u00EDch, a\u00A0to konkr\u00E9tn\u011B s\u00A0klozapinem, p\u0159\u00EDpadn\u011B olanzapinem. M\u00E1 jen n\u011Bkolik kontraindikac\u00ED a\u00A0pro relativn\u011B n\u00EDzk\u00FD po\u010Det ne\u017E\u00E1douc\u00EDch \u00FA\u010Dink\u016F je rovn\u011B\u017E dob\u0159e sn\u00E1\u0161en\u00FD." . "1"^^ . . . "Amisulprid v l\u00E9\u010Db\u011B schizofrenie"@cs . . "\u010Cesk\u00E1 a slovensk\u00E1 neurologie a neurochirurgie" . . "185366" . "schizophrenia"@en . . "74/107" . . "Amisulpride in the Treatment od Schizophrenia"@en . "Amisulprid v l\u00E9\u010Db\u011B schizofrenie"@cs . "Ustohal, Libor" . . . . "V, Z(MSM0021622404)" . "Amisulprid je antipsychotikum druh\u00E9 generace p\u016Fsob\u00EDc\u00ED jako antagonista dopaminov\u00FDch D2/\u2028/D3 receptor\u016F. \u00DA\u010Dinkuje tzv. bif\u00E1zicky \u2013 v\u00A0n\u00EDzk\u00FDch d\u00E1vk\u00E1ch zp\u016Fsobuje zv\u00FD\u0161en\u00ED dopaminov\u00E9 neurotransmise, ve vy\u0161\u0161\u00EDch d\u00E1vk\u00E1ch naopak jej\u00ED sn\u00ED\u017Een\u00ED. Osv\u011Bd\u010Dil se nejen v\u00A0l\u00E9\u010Db\u011B pozitivn\u00EDch p\u0159\u00EDznak\u016F schizofrenie, ale p\u0159\u00EDzniv\u011B p\u016Fsob\u00ED i\u00A0na negativn\u00ED a\u00A0patrn\u011B tak\u00E9 na afektivn\u00ED (depresivn\u00ED) p\u0159\u00EDznaky a\u00A0kognitivn\u00ED dysfunkci. Efektivn\u00ED je v\u00A0monoterapii, av\u0161ak existuj\u00ED i\u00A0d\u016Fkazy, \u017Ee m\u016F\u017Ee b\u00FDt \u00FA\u010Dinn\u00FD t\u00E9\u017E v\u00A0kombinac\u00EDch, a\u00A0to konkr\u00E9tn\u011B s\u00A0klozapinem, p\u0159\u00EDpadn\u011B olanzapinem. M\u00E1 jen n\u011Bkolik kontraindikac\u00ED a\u00A0pro relativn\u011B n\u00EDzk\u00FD po\u010Det ne\u017E\u00E1douc\u00EDch \u00FA\u010Dink\u016F je rovn\u011B\u017E dob\u0159e sn\u00E1\u0161en\u00FD."@cs . "RIV/65269705:_____/11:#0001435" . "Amisulpride is a second generation D2 and D3 receptor blocking antipsychotic agent. It has so called biphasic affect \u2013 low doses increase and higher doses decrease dopaminergic neurotransmission. It has proven efficacy in the treatment of positive as well as negative symptoms of schizophrenia and, it is assumed that it also impacts on affective (depressive) symptoms and cognitive dysfunction. Amisulpride is effective as monotherapy although some evidence also exists of its efficacy when used in combinations, namely in combination with clozapine and, alternatively, olanzapine. It has only a few contraindications and, due to relatively low number of side-effects, is well-tolerated."@en . "Amisulprid v l\u00E9\u010Db\u011B schizofrenie" . . . "6" . . "RIV/65269705:_____/11:#0001435!RIV12-MZ0-65269705" . "3"^^ .