"Dermatologie pro praxi" . . "Adam, Zden\u011Bk" . "RIV/65269705:_____/11:#0001371" . . "6"^^ . . "6"^^ . . . "Schnitzler\u016Fv syndrom je vz\u00E1cn\u00E1 choroba, charakterizovan\u00E1 chronickou kop\u0159ivkou a p\u0159\u00EDtomnost\u00ED monoklon\u00E1ln\u00EDho imunoglobulinu t\u0159\u00EDdy IgM a dal\u0161\u00EDmi znaky. Diagn\u00F3zu jsme u na\u0161eho pacienta stanovili v roce 1996 a v pr\u016Fb\u011Bhu 12 let jsme u n\u011Bj testovali a vyhodnocovali \u010Detn\u00E9 l\u00E9\u010Debn\u00E9 postupy. Bolesti kost\u00ED v oblastech s prok\u00E1zan\u00FDmi osteolyticko-osteosklerotick\u00FDmi zm\u011Bnami zcela vymizely p\u0159i pravideln\u00E9 aplikaci bisfosfon\u00E1t\u016F (pamidronat a pozd\u011Bji klodronat). Do\u010Dasn\u011B a \u010D\u00E1ste\u010Dn\u011B p\u0159\u00EDnosnou byla l\u00E9\u010Dba interferonem alfa a n\u00E1sledn\u011B sv\u011Btlol\u00E9\u010Dba PUVA. Jako zcela nep\u0159\u00EDnosn\u00E9 byly vyhodnoceny n\u00E1sleduj\u00EDc\u00ED postupy: vysok\u00E9 d\u00E1vky dexametazononu, l\u00E9\u010Dba 2-chlordeoxyadenosinem, l\u00E9\u010Dba cyklosporinem, l\u00E9\u010Dba kombinac\u00ED bortezomib, thalidomid dexametazon. Teprve pod\u00E1n\u00ED prepar\u00E1tu anakinra z\u00E1sadn\u011B zm\u011Bnilo \u017Eivot nemocn\u00E9ho, zcela odstranilo ko\u017En\u00ED projevy a upravilo hodnoty CRP a hemoglobinu na normu." . . . "1" . . "Krej\u010D\u00ED, Marta" . . . . "Schnitzler syndrome \u2013 chronic urticaria + monoclonal gammopathy IgM + osteolytic-osteosklerotic bone changes"@en . "H\u00E1jek, Roman" . "schnitzler syndrome"@en . "Schnitzler\u016Fv syndrom je vz\u00E1cn\u00E1 choroba, charakterizovan\u00E1 chronickou kop\u0159ivkou a p\u0159\u00EDtomnost\u00ED monoklon\u00E1ln\u00EDho imunoglobulinu t\u0159\u00EDdy IgM a dal\u0161\u00EDmi znaky. Diagn\u00F3zu jsme u na\u0161eho pacienta stanovili v roce 1996 a v pr\u016Fb\u011Bhu 12 let jsme u n\u011Bj testovali a vyhodnocovali \u010Detn\u00E9 l\u00E9\u010Debn\u00E9 postupy. Bolesti kost\u00ED v oblastech s prok\u00E1zan\u00FDmi osteolyticko-osteosklerotick\u00FDmi zm\u011Bnami zcela vymizely p\u0159i pravideln\u00E9 aplikaci bisfosfon\u00E1t\u016F (pamidronat a pozd\u011Bji klodronat). Do\u010Dasn\u011B a \u010D\u00E1ste\u010Dn\u011B p\u0159\u00EDnosnou byla l\u00E9\u010Dba interferonem alfa a n\u00E1sledn\u011B sv\u011Btlol\u00E9\u010Dba PUVA. Jako zcela nep\u0159\u00EDnosn\u00E9 byly vyhodnoceny n\u00E1sleduj\u00EDc\u00ED postupy: vysok\u00E9 d\u00E1vky dexametazononu, l\u00E9\u010Dba 2-chlordeoxyadenosinem, l\u00E9\u010Dba cyklosporinem, l\u00E9\u010Dba kombinac\u00ED bortezomib, thalidomid dexametazon. Teprve pod\u00E1n\u00ED prepar\u00E1tu anakinra z\u00E1sadn\u011B zm\u011Bnilo \u017Eivot nemocn\u00E9ho, zcela odstranilo ko\u017En\u00ED projevy a upravilo hodnoty CRP a hemoglobinu na normu."@cs . "V" . "Schnitzler syndrome \u2013 chronic urticaria + monoclonal gammopathy IgM + osteolytic-osteosklerotic bone changes"@en . "Pr\u00E1\u0161ek, Ji\u0159\u00ED" . "5" . "Schnitzler\u016Fv syndrom = chronick\u00E1 urtika + monoklon\u00E1ln\u00ED gamapatie typu IgM + osteolytick\u00E9-osteosklerotick\u00E9 kostn\u00ED zm\u011Bny" . "4"^^ . "[41D8DA89AA7E]" . . "Schnitzler syndrome is a rare disorder characterized by chronic urticaria, the presence of monoclonal class IgM immunoglobulin, lymphadenopathy and fevers. We report on a patient who was diagnosed in 1996 and over the next 12 years underwent a number of therapies. Bone pain associated with proven osteolytic and osteosclerotic lesions resolved on regular bisphosphonate treatment with pamidronate and, later, clodronate. The patient had transient benefit from treatments with interferon-alpha and with PUVA. No therapeutic effects were seen with high-dose dexamethasone, 2-chlordeoxyadenosin, cyclosporine, or the combination of bortezomib, thalidomide, and dexamethasone. However, on therapy with anakinra the patient\u2019s skin symptoms resolved completely and the values of CRP and hemoglobin normalized."@en . . "1802-2960" . "RIV/65269705:_____/11:#0001371!RIV12-MZ0-65269705" . "Pour, Lud\u011Bk" . . "Schnitzler\u016Fv syndrom = chronick\u00E1 urtika + monoklon\u00E1ln\u00ED gamapatie typu IgM + osteolytick\u00E9-osteosklerotick\u00E9 kostn\u00ED zm\u011Bny"@cs . . "Schnitzler\u016Fv syndrom = chronick\u00E1 urtika + monoklon\u00E1ln\u00ED gamapatie typu IgM + osteolytick\u00E9-osteosklerotick\u00E9 kostn\u00ED zm\u011Bny" . . "CZ - \u010Cesk\u00E1 republika" . "228279" . . "Neubauer, Ji\u0159\u00ED" . . "Schnitzler\u016Fv syndrom = chronick\u00E1 urtika + monoklon\u00E1ln\u00ED gamapatie typu IgM + osteolytick\u00E9-osteosklerotick\u00E9 kostn\u00ED zm\u011Bny"@cs .