. "V\u00EDce ne\u017E 10 let trvaj\u00EDc\u00ED kompletn\u00ED remise monoklon\u00E1ln\u00ED gamapatie nejist\u00E9ho v\u00FDznamu a vymizen\u00ED nefrotick\u00E9ho syndromu vznikl\u00E9ho na podkladn\u011B light chain deposition disease po l\u00E9\u010Db\u011B vinkristinem, adriamycinem a vysok\u00FDmi d\u00E1vkami dexametazonu (VAD)" . . "multiple myeloma; light chain deposition disease"@en . . . . "[DDEBE5845868]" . . "P(LC06027)" . "Depozita lehk\u00FDch \u0159et\u011Bzc\u016F ve form\u011B amorfn\u00EDch hmot (light chain deposition disease) po\u0161kozuj\u00ED nej\u010Dast\u011Bji ledviny, m\u00E9n\u011B \u010Dasto po\u0161kozuj\u00ED jin\u00E9 org\u00E1ny. Onemocn\u011Bn\u00ED je podstatn\u011B vz\u00E1cn\u011Bj\u0161\u00ED ne\u017E AL-amyloid\u00F3za. Prvn\u00EDmi p\u0159\u00EDznaky light chain deposition disease u na\u0161eho nemocn\u00E9ho byly symetrick\u00E9 otoky doln\u00EDch kon\u010Detin, otoky v\u00ED\u010Dek, erytrocyturie a nefrotick\u00E1 proteinurie. Nemoc byla diagnostikov\u00E1na z biopsie ledviny, proveden\u00E9 a\u017E ve f\u00E1zi rozvinut\u00E9ho nefrotick\u00E9ho syndromu se sn\u00ED\u017Een\u00EDm filtrace. V aspir\u00E1tu kostn\u00ED d\u0159en\u011B bylo 0,8 % plazmocyt\u016F, v s\u00E9ru byl p\u0159\u00EDtomen monoklon\u00E1ln\u00ED imunoglobulin IgG-k a v mo\u010Di byly p\u0159\u00EDtomny voln\u00E9 \u0159et\u011Bzce k. Krevn\u00ED obraz byl v norm\u011B a nebyly osteolytick\u00E9 zm\u011Bny skeletu. Diagn\u00F3za byla tedy uzav\u0159ena jako monoklon\u00E1ln\u00ED gamapatie nejist\u00E9ho v\u00FDznamu (MGUS). Pacient byl l\u00E9\u010Den 10 cykly chemoterapie obsahuj\u00EDc\u00ED vinkristin, adriamycin a vysok\u00E9 d\u00E1vky dexametazonu (VAD)."@cs . "V\u00EDce ne\u017E 10 let trvaj\u00EDc\u00ED kompletn\u00ED remise monoklon\u00E1ln\u00ED gamapatie nejist\u00E9ho v\u00FDznamu a vymizen\u00ED nefrotick\u00E9ho syndromu vznikl\u00E9ho na podkladn\u011B light chain deposition disease po l\u00E9\u010Db\u011B vinkristinem, adriamycinem a vysok\u00FDmi d\u00E1vkami dexametazonu (VAD)" . "V\u00EDce ne\u017E 10 let trvaj\u00EDc\u00ED kompletn\u00ED remise monoklon\u00E1ln\u00ED gamapatie nejist\u00E9ho v\u00FDznamu a vymizen\u00ED nefrotick\u00E9ho syndromu vznikl\u00E9ho na podkladn\u011B light chain deposition disease po l\u00E9\u010Db\u011B vinkristinem, adriamycinem a vysok\u00FDmi d\u00E1vkami dexametazonu (VAD)"@cs . . "Krej\u010D\u00ED, Marta" . "0042-773X" . "295648" . "Depozita lehk\u00FDch \u0159et\u011Bzc\u016F ve form\u011B amorfn\u00EDch hmot (light chain deposition disease) po\u0161kozuj\u00ED nej\u010Dast\u011Bji ledviny, m\u00E9n\u011B \u010Dasto po\u0161kozuj\u00ED jin\u00E9 org\u00E1ny. Onemocn\u011Bn\u00ED je podstatn\u011B vz\u00E1cn\u011Bj\u0161\u00ED ne\u017E AL-amyloid\u00F3za. Prvn\u00EDmi p\u0159\u00EDznaky light chain deposition disease u na\u0161eho nemocn\u00E9ho byly symetrick\u00E9 otoky doln\u00EDch kon\u010Detin, otoky v\u00ED\u010Dek, erytrocyturie a nefrotick\u00E1 proteinurie. Nemoc byla diagnostikov\u00E1na z biopsie ledviny, proveden\u00E9 a\u017E ve f\u00E1zi rozvinut\u00E9ho nefrotick\u00E9ho syndromu se sn\u00ED\u017Een\u00EDm filtrace. V aspir\u00E1tu kostn\u00ED d\u0159en\u011B bylo 0,8 % plazmocyt\u016F, v s\u00E9ru byl p\u0159\u00EDtomen monoklon\u00E1ln\u00ED imunoglobulin IgG-k a v mo\u010Di byly p\u0159\u00EDtomny voln\u00E9 \u0159et\u011Bzce k. Krevn\u00ED obraz byl v norm\u011B a nebyly osteolytick\u00E9 zm\u011Bny skeletu. Diagn\u00F3za byla tedy uzav\u0159ena jako monoklon\u00E1ln\u00ED gamapatie nejist\u00E9ho v\u00FDznamu (MGUS). Pacient byl l\u00E9\u010Den 10 cykly chemoterapie obsahuj\u00EDc\u00ED vinkristin, adriamycin a vysok\u00E9 d\u00E1vky dexametazonu (VAD)." . "3" . "Mayer, Ji\u0159\u00ED" . "7"^^ . "56" . "More than 10years of complete remission of monoclonal gammopathy of undetermined significance and cessation of light chain deposition disease-associated nephrotic syndrome following treatment with vincristine, adriamycin and high-dose dexamethasone (VAD)"@en . . "CZ - \u010Cesk\u00E1 republika" . . . . . "Adam, Zden\u011Bk" . "H\u00E1jek, Roman" . "Pour, Lud\u011Bk" . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" . "V\u00EDce ne\u017E 10 let trvaj\u00EDc\u00ED kompletn\u00ED remise monoklon\u00E1ln\u00ED gamapatie nejist\u00E9ho v\u00FDznamu a vymizen\u00ED nefrotick\u00E9ho syndromu vznikl\u00E9ho na podkladn\u011B light chain deposition disease po l\u00E9\u010Db\u011B vinkristinem, adriamycinem a vysok\u00FDmi d\u00E1vkami dexametazonu (VAD)"@cs . . "\u010Cerm\u00E1kov\u00E1, Zde\u0148ka" . "Light chain deposits in the form of amorphous material (light chain deposition disease) damage most frequently kidneys and, less frequently, they affect other organs. The incidence of light chain deposition disease is much lower than that of AL-amyloidosis. Symmetrical swelling of both legs, swelling of the eye lids, erythrocyturia and nephrotic proteinuria were the first signs of light chain deposition disease in our patient. The disease was diagnosed from kidney biopsy performed at the stage of advanced nephrotic syndrome with reduced filtration. The bone marrow aspirate contained 0.8% of plasma cells, serum contained monoclonal immunoglobulin IgG-k and urine contained free k chains. Blood count was normal and no osteolytic changes to the skeleton were identified. The patient was, therefore, diagnosed with monoclonal gammopathy of undetermined significance (MGUS) and was treated with 10 cycles of chemotherapy consisting of vincristine, adriamycin and high/dose dexamethasone (VAD)."@en . "Hu\u0161ek, Karel" . . "K\u0159ivanov\u00E1, Andrea" . . "RIV/65269705:_____/10:#0001129!RIV11-MSM-65269705" . . . . "10"^^ . "More than 10years of complete remission of monoclonal gammopathy of undetermined significance and cessation of light chain deposition disease-associated nephrotic syndrome following treatment with vincristine, adriamycin and high-dose dexamethasone (VAD)"@en . "RIV/65269705:_____/10:#0001129" . . . "8"^^ . .