"8"^^ . . . . "15"^^ . . . . . "Zahradov\u00E1, Lenka" . . "Negative prognostic significance of two or more cytogenetic abnormalities in multiple myeloma patients treated with autologous stem cell transplantation"@en . . "000277412700003" . . "multiple myeloma"@en . "7"^^ . "Negative prognostic significance of two or more cytogenetic abnormalities in multiple myeloma patients treated with autologous stem cell transplantation" . . "2" . "274157" . . . "SK - Slovensk\u00E1 republika" . . . . "[6B77C2473C5F]" . "Malignant plasma cells in multiple myeloma (MM) are frequently characterized by complex karyotypes and chromosome instability. These cytogenetic changes are considered important prognostic indicators in MM patients. We have studied samples from 68 patients with newly diagnosed MM who were treated with high-dose chemotherapy and autologous stem cell transplantation. G-banding revealed abnormal karyotypes in 14 of 55 patients (25%) who had informative conventional cytogenetics. The combination of cytoplasmic immunoglobulin light chain labeling and interphase fluorescent in situ hybridization (cIg-FISH) revealed the presence of genetic aberrations in 53 of 68 patients (78%). Chromosome 13 abnormalities were found in 33 patients (50%) and IgH rearrangements in 36 patients (56.25%)."@en . "Negative prognostic significance of two or more cytogenetic abnormalities in multiple myeloma patients treated with autologous stem cell transplantation"@en . "Oltov\u00E1, Alexandra" . . "Krej\u010D\u00ED, Marta" . "Pour, Lud\u011Bk" . . "Gre\u0161l\u00EDkov\u00E1, H." . "Malignant plasma cells in multiple myeloma (MM) are frequently characterized by complex karyotypes and chromosome instability. These cytogenetic changes are considered important prognostic indicators in MM patients. We have studied samples from 68 patients with newly diagnosed MM who were treated with high-dose chemotherapy and autologous stem cell transplantation. G-banding revealed abnormal karyotypes in 14 of 55 patients (25%) who had informative conventional cytogenetics. The combination of cytoplasmic immunoglobulin light chain labeling and interphase fluorescent in situ hybridization (cIg-FISH) revealed the presence of genetic aberrations in 53 of 68 patients (78%). Chromosome 13 abnormalities were found in 33 patients (50%) and IgH rearrangements in 36 patients (56.25%)." . . . . "RIV/65269705:_____/10:#0001038" . "Adam, Zden\u011Bk" . "Negative prognostic significance of two or more cytogenetic abnormalities in multiple myeloma patients treated with autologous stem cell transplantation" . "57" . . "Filkov\u00E1, Hana" . . "Kugl\u00EDk, Petr" . "Neoplasma" . "I, P(LC06027), P(NR9317), V, Z(MSM0021622415), Z(MSM0021622434)" . . . . "0028-2685" . "RIV/65269705:_____/10:#0001038!RIV11-MZ0-65269705" . "H\u00E1jek, Roman" .