"MicroRNAs (miRNAs) are small RNA molecules acting as post-transcriptional regulators of gene expression. They are dynamically regulated during cell differentiation, proliferation and apoptosis. The predicted number of human miRNAs is approximately 1000 and they regulate about 20-30 % of all expressed proteins. Many studies have shown that miRNAs are aberrantly expressed in cancer cells, suggesting that they might act as a novel class of oncogenes or tumor supressors. First evidence of involvement of miRNAs in cancer came from molecular studies characterizing the 13q14 deletion in human chronic lymphocytic leukemia. Two miR genes are located at 13q14.3 and both of these genes, miR-15a and miR-16-1, are down-regulated in more than 60% of CLL cases. Moreover, miRNAs expression can be associated with known prognostic markers in CLL (expression of ZAP-70, unmutated IgVh vs mutated IgVh, deletion and/or mutation of p53 gene)."@en . "271242" . . . . "Posp\u00ED\u0161ilov\u00E1, \u0160\u00E1rka" . . "MicroRNA v patogenezi chronick\u00E9 lymfocyt\u00E1rn\u00ED leukemie a jejich prognostick\u00FD v\u00FDznam."@cs . "3"^^ . "RIV/65269705:_____/10:#0000951" . . . "MicroRNA v patogenezi chronick\u00E9 lymfocyt\u00E1rn\u00ED leukemie a jejich prognostick\u00FD v\u00FDznam."@cs . . "MicroRNA v patogenezi chronick\u00E9 lymfocyt\u00E1rn\u00ED leukemie a jejich prognostick\u00FD v\u00FDznam." . "MicroRNAs in pathogenesis of chronic lymphocytic leukemia (CLL) and their prognostic significance."@en . "[AA21F6672E33]" . "MicroRNAs in pathogenesis of chronic lymphocytic leukemia (CLL) and their prognostic significance."@en . "MicroRNA (miRNA) jsou mal\u00E9 RNA molekuly p\u016Fsob\u00EDc\u00ED jako post-transkrip\u010Dn\u00ED regul\u00E1tory genov\u00E9 exprese. P\u0159edpokl\u00E1dan\u00FD po\u010Det miRNA se odhaduje na 1000 gen\u016F v lidsk\u00E9m genomu, kter\u00E9 reguluj\u00ED 20-30 % protein\u016F. Mnoho studi\u00ED z posledn\u00ED doby popsalo aberantn\u00ED expresi microRNA u n\u00E1dorov\u00FDch bun\u011Bk a jejich mo\u017Enou \u00FAlohu jako tumor-supresor\u016F a proto-onkogen\u016F. Jedn\u00EDm z prvn\u00EDch potvrzen\u00ED deregulace miRNA u n\u00E1dor\u016F byl objev dvou microRNA (miR-15a, miR-16-1) v oblasti 13q14, kter\u00E1 je \u010Dasto deletovan\u00E1 u chronick\u00E9 lymfocyt\u00E1rn\u00ED leukemie (CLL). P\u0159i dal\u0161\u00EDm studiu byly pops\u00E1ny miRNA, jejich\u017E expresi lze asociovat s ji\u017E zn\u00E1m\u00FDmi prognostick\u00FDmi faktory u CLL (m\u00EDra exprese tyrozikin\u00E1zy ZAP-70, mutovan\u00E9 IgVh vs. nemutovan\u00E9 IgVh, delece a/nebo mutace p53 genu). Pr\u00E1ce publikovan\u00E9 v posledn\u00EDch n\u011Bkolika letech ukazuj\u00ED mo\u017En\u00FD v\u00FDznam miRNA v progresi/patogenezi chronick\u00E9 lymfocyt\u00E1rn\u00ED leukemie." . "16" . . . "3"^^ . "P(NR9293), P(NS10439), Z(MSM0021622430)" . . "1213-5763" . "Transfuze a hematologie dnes" . . "3"^^ . "Suppl. 1" . "microRNA"@en . "RIV/65269705:_____/10:#0000951!RIV11-MZ0-65269705" . "MicroRNA (miRNA) jsou mal\u00E9 RNA molekuly p\u016Fsob\u00EDc\u00ED jako post-transkrip\u010Dn\u00ED regul\u00E1tory genov\u00E9 exprese. P\u0159edpokl\u00E1dan\u00FD po\u010Det miRNA se odhaduje na 1000 gen\u016F v lidsk\u00E9m genomu, kter\u00E9 reguluj\u00ED 20-30 % protein\u016F. Mnoho studi\u00ED z posledn\u00ED doby popsalo aberantn\u00ED expresi microRNA u n\u00E1dorov\u00FDch bun\u011Bk a jejich mo\u017Enou \u00FAlohu jako tumor-supresor\u016F a proto-onkogen\u016F. Jedn\u00EDm z prvn\u00EDch potvrzen\u00ED deregulace miRNA u n\u00E1dor\u016F byl objev dvou microRNA (miR-15a, miR-16-1) v oblasti 13q14, kter\u00E1 je \u010Dasto deletovan\u00E1 u chronick\u00E9 lymfocyt\u00E1rn\u00ED leukemie (CLL). P\u0159i dal\u0161\u00EDm studiu byly pops\u00E1ny miRNA, jejich\u017E expresi lze asociovat s ji\u017E zn\u00E1m\u00FDmi prognostick\u00FDmi faktory u CLL (m\u00EDra exprese tyrozikin\u00E1zy ZAP-70, mutovan\u00E9 IgVh vs. nemutovan\u00E9 IgVh, delece a/nebo mutace p53 genu). Pr\u00E1ce publikovan\u00E9 v posledn\u00EDch n\u011Bkolika letech ukazuj\u00ED mo\u017En\u00FD v\u00FDznam miRNA v progresi/patogenezi chronick\u00E9 lymfocyt\u00E1rn\u00ED leukemie."@cs . "MicroRNA v patogenezi chronick\u00E9 lymfocyt\u00E1rn\u00ED leukemie a jejich prognostick\u00FD v\u00FDznam." . . . "CZ - \u010Cesk\u00E1 republika" . . "Mr\u00E1z, Marek" . . . "Mayer, Ji\u0159\u00ED" . . .