"0042-773X" . . "Pour, Lud\u011Bk" . . "Krej\u010D\u00ED, Marta" . . . "3" . "L\u00E9\u010Dba AL-amyloid\u00F3zy - v\u00FDsledky jednoho pracovi\u0161t\u011B a p\u0159ehled publikovan\u00FDch zku\u0161enost\u00ED s nov\u00FDmi l\u00E9ky (bortezomibem, thalidomidem a lenalidomidem) u AL-amyloid\u00F3zy"@cs . . "13"^^ . "Treatment of AL-amyloidosis - results from one clinic and review of published experience with new agents (bortezomib, thalidomide and lenalidomide) in AL - amyloidosis"@en . "\u0160mardov\u00E1, Jana" . "Od roku 1999 bylo na na\u0161em pracovi\u0161ti l\u00E9\u010Deno 15 pacient\u016F s depozity lehk\u00FDch \u0159et\u011Bzc\u016F ve form\u011B AL-amyloid\u00F3zy a 2 pacienti s depozic\u00ED lehk\u00FDch \u0159et\u011Bzc\u016F ve form\u011B amorfn\u00EDch hmot (light chain deposition disease). L\u00E9\u010Debn\u00E1 kombinace bortezomib, cyklofosfamid a dexametazon (VCD) byla pou\u017Eita ve 3 p\u0159\u00EDpadech. V 1. p\u0159\u00EDpad\u011B (po ukon\u010Den\u00FDch 6 cyklech CTD s v\u00FDsledkem PR) navodila kompletn\u00ED hematologickou remisi, ve 2. (intoleranc\u00ED thalidomidu ji\u017E v 1. m\u011Bs\u00EDci l\u00E9\u010Dby) navodila tak\u00E9 kompletn\u00ED remisi a ve 3. p\u0159\u00EDpad\u011B (po 5 cyklech CTD s v\u00FDsledkem PR) dos\u00E1hla aplikace 2 cykl\u016F CVD tak\u00E9 CR. Pouze jedna ze 3 pacientek je sledov\u00E1na d\u00E9le ne\u017E 12 m\u011Bs\u00EDc\u016F a je mo\u017En\u00E9 u n\u00ED vyhodnotit org\u00E1novou l\u00E9\u010Debnou odpov\u011B\u010F, u t\u00E9to pacientky vymizel nefrotick\u00FD syndrom, tak\u017Ee byla dosa\u017Eena org\u00E1nov\u00E1 CR. \u010Casn\u00E9 stanoven\u00ED diagn\u00F3zy umo\u017En\u00ED pod\u00E1vat agresivn\u00ED l\u00E9\u010Dbu s nad\u011Bj\u00ED na kompletn\u00ED hematologickou a org\u00E1novou l\u00E9\u010Debnou odpov\u011B\u010F. Nov\u00E9 l\u00E9ky thalidomid a bortezomib d\u00E1le roz\u0161i\u0159uj\u00ED l\u00E9\u010Debn\u00E9 mo\u017Enosti."@cs . . "Mayer, Ji\u0159\u00ED" . "\u010Cerm\u00E1kov\u00E1, Zde\u0148ka" . . "\u0160t\u011Bp\u00E1nkov\u00E1, So\u0148a" . "RIV/65269705:_____/10:#0000909" . . "Od roku 1999 bylo na na\u0161em pracovi\u0161ti l\u00E9\u010Deno 15 pacient\u016F s depozity lehk\u00FDch \u0159et\u011Bzc\u016F ve form\u011B AL-amyloid\u00F3zy a 2 pacienti s depozic\u00ED lehk\u00FDch \u0159et\u011Bzc\u016F ve form\u011B amorfn\u00EDch hmot (light chain deposition disease). L\u00E9\u010Debn\u00E1 kombinace bortezomib, cyklofosfamid a dexametazon (VCD) byla pou\u017Eita ve 3 p\u0159\u00EDpadech. V 1. p\u0159\u00EDpad\u011B (po ukon\u010Den\u00FDch 6 cyklech CTD s v\u00FDsledkem PR) navodila kompletn\u00ED hematologickou remisi, ve 2. (intoleranc\u00ED thalidomidu ji\u017E v 1. m\u011Bs\u00EDci l\u00E9\u010Dby) navodila tak\u00E9 kompletn\u00ED remisi a ve 3. p\u0159\u00EDpad\u011B (po 5 cyklech CTD s v\u00FDsledkem PR) dos\u00E1hla aplikace 2 cykl\u016F CVD tak\u00E9 CR. Pouze jedna ze 3 pacientek je sledov\u00E1na d\u00E9le ne\u017E 12 m\u011Bs\u00EDc\u016F a je mo\u017En\u00E9 u n\u00ED vyhodnotit org\u00E1novou l\u00E9\u010Debnou odpov\u011B\u010F, u t\u00E9to pacientky vymizel nefrotick\u00FD syndrom, tak\u017Ee byla dosa\u017Eena org\u00E1nov\u00E1 CR. \u010Casn\u00E9 stanoven\u00ED diagn\u00F3zy umo\u017En\u00ED pod\u00E1vat agresivn\u00ED l\u00E9\u010Dbu s nad\u011Bj\u00ED na kompletn\u00ED hematologickou a org\u00E1novou l\u00E9\u010Debnou odpov\u011B\u010F. Nov\u00E9 l\u00E9ky thalidomid a bortezomib d\u00E1le roz\u0161i\u0159uj\u00ED l\u00E9\u010Debn\u00E9 mo\u017Enosti." . "Treatment of AL-amyloidosis - results from one clinic and review of published experience with new agents (bortezomib, thalidomide and lenalidomide) in AL - amyloidosis"@en . "K\u0159en, Leo\u0161" . . . "L\u00E9\u010Dba AL-amyloid\u00F3zy - v\u00FDsledky jednoho pracovi\u0161t\u011B a p\u0159ehled publikovan\u00FDch zku\u0161enost\u00ED s nov\u00FDmi l\u00E9ky (bortezomibem, thalidomidem a lenalidomidem) u AL-amyloid\u00F3zy"@cs . "Zahradov\u00E1, Lenka" . . . "20"^^ . "Adam, Zden\u011Bk" . "268103" . "P(GP301/09/P457), P(LC06027), P(NS10406), P(NS10408), Z(MSM0021622434)" . "AL-amyloidosis"@en . . . . . "[CDF0E8D30397]" . . . . . "5 patients with light chain deposits in the form of AL-amyloidosis and 2 patients with light chain deposition as amorphous matter (light chain deposition disease) were treated at our clinic as of 1999. Combination of thal, dexamethasone and cyclophosphamide (CTD) was used in 4 patients. Treatment combination of Velcade, cyclophosphamide and dexamethasone (VCD) was used in 3 patients. In one patient (6 completed CTD cycles with the PR result) this combination led to complete haematological remission, complete remission was also achieved in the second patient and the application of 2 CVD cycles led to CR in the third (5 CTD cycles with PR result). Just one of the 3 female patients has been followed up for more than 12 months and so it is possible to evaluate organ treatment response in this patient; nephrotic syndrome ceased, meaning that organ CR has been achieved. Early diagnosis enables administration of aggressive treatment with the outlook of complete haematological and organ treatment response."@en . . . . "Moulis, Mojm\u00EDr" . "Kov\u00E1\u0159ov\u00E1, Lucie" . . . "K\u0159ivanov\u00E1, Andrea" . "H\u00E1jek, Roman" . . . . "L\u00E9\u010Dba AL-amyloid\u00F3zy - v\u00FDsledky jednoho pracovi\u0161t\u011B a p\u0159ehled publikovan\u00FDch zku\u0161enost\u00ED s nov\u00FDmi l\u00E9ky (bortezomibem, thalidomidem a lenalidomidem) u AL-amyloid\u00F3zy" . . "56" . "L\u00E9\u010Dba AL-amyloid\u00F3zy - v\u00FDsledky jednoho pracovi\u0161t\u011B a p\u0159ehled publikovan\u00FDch zku\u0161enost\u00ED s nov\u00FDmi l\u00E9ky (bortezomibem, thalidomidem a lenalidomidem) u AL-amyloid\u00F3zy" . "RIV/65269705:_____/10:#0000909!RIV11-MZ0-65269705" . . "CZ - \u010Cesk\u00E1 republika" . "16"^^ . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" .