"Mayer, Ji\u0159\u00ED" . "Human genome sequencing - next generation technology or will the routine sequencing of human genome be possible?"@en . "Sekvenov\u00E1n\u00ED lidsk\u00E9ho genomu - technologie nov\u00E9 generace aneb budeme rutinn\u011B sekvenovat lidsk\u00E9 genomy?" . . . . "1803-6597" . "3"^^ . "P(NR9293)" . . . "3"^^ . . "RIV/65269705:_____/09:#0000794!RIV10-MZ0-65269705" . "7"^^ . . . "Human genome sequencing - next generation technology or will the routine sequencing of human genome be possible?"@en . "\u010Casopis l\u00E9ka\u0159\u016F \u010Desk\u00FDch" . "RIV/65269705:_____/09:#0000794" . "CZ - \u010Cesk\u00E1 republika" . "340608" . "[A06CB4C839A6]" . "Sekvenov\u00E1n\u00ED lidsk\u00E9ho genomu - technologie nov\u00E9 generace aneb budeme rutinn\u011B sekvenovat lidsk\u00E9 genomy?"@cs . "hese new technologies based on on principles of massive parallel sequencing enable a massive increase of sequencing capacity and in parallel also a fundamental decrease of costs. This major technological breakthrough allowed development of the whole-genome sequencing including analyses of individual human genomes. It also started the era of personal genomics. These studies brought substantial information about interpersonal differences in genome structure (through characterization of nucleotide polymorphisms, DNA deletions and amplifications etc.). Sequencing af cancer cell genomes, e.g. acute myeloid leukemia has already brought first important clinically relevant results. Although currently we are still unable to interpret the relevance of all detected genome variants, it is obvious, that the possibility to sequence individual human genomes represents a fundamental breakthrough not only in DNA diagnostics but also in clinical medicine."@en . . . . "Sekvenov\u00E1n\u00ED lidsk\u00E9ho genomu - technologie nov\u00E9 generace aneb budeme rutinn\u011B sekvenovat lidsk\u00E9 genomy?"@cs . "7" . "Tich\u00FD, Boris" . "Sekvenov\u00E1n\u00ED lidsk\u00E9ho genomu - technologie nov\u00E9 generace aneb budeme rutinn\u011B sekvenovat lidsk\u00E9 genomy?" . "Human genome sequencing"@en . . . "Nov\u00E9 technologie zalo\u017Een\u00E9 na principu masivn\u00EDho paraleln\u00EDho sekvenov\u00E1n\u00ED (nap\u0159. Roche/454, Illumina Genome Analyzer IIx, Life Technologies SOLiD 3 a dal\u0161\u00ED) umo\u017E\u0148uj\u00ED z\u00E1sadn\u00ED nav\u00FD\u0161en\u00ED kapacity sekven\u00E1tor\u016F a v\u00FDrazn\u00E9 sn\u00ED\u017Een\u00ED ceny. Tento v\u00FDznamn\u00FD technologick\u00FD pokrok umo\u017Enil rozvoj celogenomov\u00E9ho sekvenov\u00E1n\u00ED v\u010Detn\u011B anal\u00FDz individu\u00E1ln\u00EDch lidsk\u00FDch genom\u016F a nastartoval rozvoj person\u00E1ln\u00ED genomiky. . Prvn\u00ED v\u00FDznamn\u00E9 aplikovateln\u00E9 v\u00FDsledky ji\u017E p\u0159ineslo sekvenov\u00E1n\u00ED genom\u016F n\u00E1dorov\u00FDch bun\u011Bk, nap\u0159. akutn\u00ED myeloidn\u00ED leuk\u00E9mie. A\u010Dkoli v sou\u010Dasn\u00E9 dob\u011B je\u0161t\u011B nejsme schopni interpretovat v\u00FDznam v\u0161ech detekovan\u00FDch variant genomu, znamen\u00E1 mo\u017Enost sekvenov\u00E1n\u00ED individu\u00E1ln\u00EDch lidsk\u00FDch genom\u016F z\u00E1sadn\u00ED zlom v DNA diagnostice i cel\u00E9 medic\u00EDn\u011B."@cs . "148" . . . "Posp\u00ED\u0161ilov\u00E1, \u0160\u00E1rka" . "Nov\u00E9 technologie zalo\u017Een\u00E9 na principu masivn\u00EDho paraleln\u00EDho sekvenov\u00E1n\u00ED (nap\u0159. Roche/454, Illumina Genome Analyzer IIx, Life Technologies SOLiD 3 a dal\u0161\u00ED) umo\u017E\u0148uj\u00ED z\u00E1sadn\u00ED nav\u00FD\u0161en\u00ED kapacity sekven\u00E1tor\u016F a v\u00FDrazn\u00E9 sn\u00ED\u017Een\u00ED ceny. Tento v\u00FDznamn\u00FD technologick\u00FD pokrok umo\u017Enil rozvoj celogenomov\u00E9ho sekvenov\u00E1n\u00ED v\u010Detn\u011B anal\u00FDz individu\u00E1ln\u00EDch lidsk\u00FDch genom\u016F a nastartoval rozvoj person\u00E1ln\u00ED genomiky. . Prvn\u00ED v\u00FDznamn\u00E9 aplikovateln\u00E9 v\u00FDsledky ji\u017E p\u0159ineslo sekvenov\u00E1n\u00ED genom\u016F n\u00E1dorov\u00FDch bun\u011Bk, nap\u0159. akutn\u00ED myeloidn\u00ED leuk\u00E9mie. A\u010Dkoli v sou\u010Dasn\u00E9 dob\u011B je\u0161t\u011B nejsme schopni interpretovat v\u00FDznam v\u0161ech detekovan\u00FDch variant genomu, znamen\u00E1 mo\u017Enost sekvenov\u00E1n\u00ED individu\u00E1ln\u00EDch lidsk\u00FDch genom\u016F z\u00E1sadn\u00ED zlom v DNA diagnostice i cel\u00E9 medic\u00EDn\u011B." .