"7"^^ . "Kov\u00E1\u0159ov\u00E1, Lucie" . . "416220" . "RIV/65269705:_____/07:#0000048!RIV08-MZ0-65269705" . . . . "Human dendritic cells have distinct roles in the regulation of immunity. In this study we analysed the kinetics and the proportion of myeloid and plasmacytoid subsets of dendritic cells (DC) in peripheral blood of 15 patients with multiple myeloma (MM) before and during treatment that included autologous transplantation. Control group of 15 healthy volunteers was evaluated by using the same approaches. Flowcytometric determination of relative and absolute cell counts in unmanipulated peripheral blood was based on the expression of surface antigens CD83 and HLA-DR. Depending on the expresion of CD11c or CD123, we divided these cells into CD11c+ dendritic cells type 1 (DC1) and CD123+ DC type 2 (DC2). Untreated patients with MM have significantly lower relative numbers of peripheral blood DC in comparison with healthy volunteers. The highest number of total DC was found after engraftment."@en . . "54" . "Dentritic cell counts and their subsets during treatment of multiple myeloma"@en . . "Human dendritic cells have distinct roles in the regulation of immunity. In this study we analysed the kinetics and the proportion of myeloid and plasmacytoid subsets of dendritic cells (DC) in peripheral blood of 15 patients with multiple myeloma (MM) before and during treatment that included autologous transplantation. Control group of 15 healthy volunteers was evaluated by using the same approaches. Flowcytometric determination of relative and absolute cell counts in unmanipulated peripheral blood was based on the expression of surface antigens CD83 and HLA-DR. Depending on the expresion of CD11c or CD123, we divided these cells into CD11c+ dendritic cells type 1 (DC1) and CD123+ DC type 2 (DC2). Untreated patients with MM have significantly lower relative numbers of peripheral blood DC in comparison with healthy volunteers. The highest number of total DC was found after engraftment." . "Po\u010Dty dendritick\u00FDch bun\u011Bk a jejich podtyp\u016F v pr\u016Fb\u011Bhu l\u00E9\u010Dby pacient\u016F s mnoho\u010Detn\u00FDmmyelomem"@cs . "P(NR8081)" . . . "Svobodn\u00EDk, Adam" . . "[35ECF47BDBE3]" . "Dentritic cell counts and their subsets during treatment of multiple myeloma"@en . . . "O\u010Dadl\u00EDkov\u00E1, Darina" . "7"^^ . . "Zahradov\u00E1, Lenka" . . "297-303" . "Penka, Miroslav" . . "4" . . . . "Dendritick\u00E9 bu\u0148ky hraj\u00ED v\u00FDznamnou \u00FAlohu v regulaci imunitn\u00EDho syst\u00E9mu. Ve studii byla analyzov\u00E1na kinetika a zastoupen\u00ED myeloidn\u00EDch a plasmacytoidn\u00EDch dendritick\u00FDch bun\u011Bk (DB), a to v perifern\u00ED krvi 15 pacient\u016F s mnoho\u010Detn\u00FDm myelomem (MM) p\u0159ed zah\u00E1jen\u00EDm l\u00E9\u010Dby zakon\u010Den\u00E9 autologn\u00ED transplantac\u00ED a v jej\u00EDm pr\u016Fb\u011Bhu. Zhodnocena byla tak\u00E9 skupina 15 zdrav\u00FDch osob. Relativn\u00ED a absolutn\u00ED po\u010Dty DB byly z\u00EDsk\u00E1ny flowcytometrickou anal\u00FDzou nemanipulovan\u00E9 pln\u00E9 krve, kdy byly hodnoceny znaky CD83 a HLA-DR. D\u00E1le byly DB rozd\u011Bleny na CD11c+ subtyp (DB1) a CD123+ subtyp (DB2). U nel\u00E9\u010Den\u00FDch pacient\u016F s MM bylo, ve srovn\u00E1n\u00ED se zdrav\u00FDmi osobami, nalezeno v\u00FDznamn\u011B ni\u017E\u0161\u00ED mno\u017Estv\u00ED perifern\u00EDch DB. Nejvy\u0161\u0161\u00ED zastoupen\u00ED DB bylo nalezeno v dob\u011B p\u0159ihojov\u00E1n\u00ED \u0161t\u011Bpu. U pacient\u016F p\u0159eva\u017Eoval zejm\u00E9na DB1 subtyp, nejni\u017E\u0161\u00ED pom\u011Br DB1/DB2 byl nalezen v afer\u00E9zn\u00EDm produktu. V 6. m\u011Bs\u00EDci po transplantaci bylo mno\u017Estv\u00ED perifern\u00EDch DB u pacient\u016F s MM srovnateln\u00E9 se zdrav\u00FDmi d\u00E1rci."@cs . "Pour, Lud\u011Bk" . "dendritic cells; multiple myeloma; flow cytometry"@en . "0028-2685" . "B\u00FCchler, Tom\u00E1\u0161" . "SK - Slovensk\u00E1 republika" . . "Dentritic cell counts and their subsets during treatment of multiple myeloma" . "Vorl\u00ED\u010Dek, Ji\u0159\u00ED" . "H\u00E1jek, Roman" . . "Dentritic cell counts and their subsets during treatment of multiple myeloma" . "RIV/65269705:_____/07:#0000048" . "Neoplasma" . "9"^^ . "Po\u010Dty dendritick\u00FDch bun\u011Bk a jejich podtyp\u016F v pr\u016Fb\u011Bhu l\u00E9\u010Dby pacient\u016F s mnoho\u010Detn\u00FDmmyelomem"@cs . .