"10"^^ . . . . "S" . "Kopustinskiene, Dalia Marija" . . "RIV/62157124:16370/14:43873139!RIV15-MSM-16370___" . "Masteikov\u00E1, Ruta" . "Kur\u0161vietiene, Lolita" . "Trumbeckaite, Sonata" . "7" . . "0032-0943" . "Baniene, Rasa" . . "Toleikis, Adolfas" . "Jakstas, Valdas" . "8"^^ . . "The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart"@en . "10.1055/s-0034-1368426" . "16370" . . "Majiene, Daiva" . . . . "Leonurus cardiaca, Lamiaceae, flavonoid, polyphenol, oxidative phosphorylation, cardiac mitochondria"@en . "Motherwort (Leonurus cardiaca) possesses antibacterial, antioxidant, anti-inflammatory, and analgesic activities, and is used as a complementary remedy to improve heart function and blood circulation. Since cardiovascular diseases are often associated with an alteration of mitochondria, the main producers of ATP in cardiac muscle cells, the aim of work was to determine bioactive constituents present in motherwort aerial parts extract in ethanol and investigate their effects on the functions of cardiac mitochondria. The results showed that constituents (chlorogenic acid, orientin, quercetin, hyperoside, and rutin) of L.cardiaca herb extract uncouple (by 20-90%) mitochondrial oxidation from phosphorylation, partially inhibit (by similar to 40%) the mitochondrial respiratory chain in cases of pyruvate and malate as well as succinate oxidation, and effectively attenuate the generation of free radicals in mitochondria." . "1"^^ . "80" . . "000336493000001" . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "[5D7A23333021]" . "Bernatoniene, Jurga" . "The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart" . "Motherwort (Leonurus cardiaca) possesses antibacterial, antioxidant, anti-inflammatory, and analgesic activities, and is used as a complementary remedy to improve heart function and blood circulation. Since cardiovascular diseases are often associated with an alteration of mitochondria, the main producers of ATP in cardiac muscle cells, the aim of work was to determine bioactive constituents present in motherwort aerial parts extract in ethanol and investigate their effects on the functions of cardiac mitochondria. The results showed that constituents (chlorogenic acid, orientin, quercetin, hyperoside, and rutin) of L.cardiaca herb extract uncouple (by 20-90%) mitochondrial oxidation from phosphorylation, partially inhibit (by similar to 40%) the mitochondrial respiratory chain in cases of pyruvate and malate as well as succinate oxidation, and effectively attenuate the generation of free radicals in mitochondria."@en . . . "The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart"@en . "RIV/62157124:16370/14:43873139" . "Savickas, Arunas" . . . "Planta Medica" . "The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart" . . "13375" .