. "0009-2770" . . . "\u010Cern\u00EDkov\u00E1, Aneta" . "V" . "108" . "10"^^ . . . . "Prol\u00E9\u010Diva mohou b\u00FDt za\u0159azena mezi strukturn\u00ED modifikace l\u00E9\u010Div ovliv\u0148uj\u00EDc\u00ED farmakologick\u00FD efekt. Prol\u00E9\u010Diva jsou inaktivn\u00ED deriv\u00E1ty aktivn\u00EDch substanc\u00ED, kter\u00E9 mus\u00ED podl\u00E9hat enzymatick\u00E9 nebo chemick\u00E9 transformaci in vivo, aby se z nich uvolnilo mate\u0159sk\u00E9 l\u00E9\u010Divo s po\u017Eadovan\u00FDm farmakodynamick\u00FDm efektem. Prol\u00E9\u010Diva mohou b\u00FDt klasifikov\u00E1na jako nosi\u010Dov\u00E1 prol\u00E9\u010Diva nebo bioprekurzory. Nosi\u010Dov\u00E1 prol\u00E9\u010Diva jsou jednoduch\u00E9 chemick\u00E9 deriv\u00E1ty, kter\u00E9 jsou jedn\u00EDm nebo dv\u011Bma kroky p\u0159evedeny na mate\u0159sk\u00E9 l\u00E9\u010Divo. Bioprekurzory vy\u017Eaduj\u00ED biotransforma\u010Dn\u00ED enzymy pro aktivaci; jejich aktivace je v\u00FDsledkem metabolick\u00FDch reakc\u00ED zahrnuj\u00EDc\u00ED oxida\u010Dn\u00ED/reduk\u010Dn\u00ED procesy. Tak\u00E9 zdvojen\u00E1 l\u00E9\u010Diva jsou \u00FA\u010Dinn\u00FDm n\u00E1strojem optimalizace l\u00E9\u010Div. Rovn\u011B\u017E tzv. soft drugs (l\u00E9\u010Diva s \u0159\u00EDzen\u00FDm metabolismem) jsou stru\u010Dn\u011B zm\u00EDn\u011Bna pro objasn\u011Bn\u00ED jejich odli\u0161nosti od prol\u00E9\u010Div" . "RIV/62157124:16370/14:43872694" . "[0CA73426A37E]" . . . . "RIV/62157124:16370/14:43872694!RIV15-MSM-16370___" . "Jamp\u00EDlek, Josef" . "Prol\u00E9\u010Diva mohou b\u00FDt za\u0159azena mezi strukturn\u00ED modifikace l\u00E9\u010Div ovliv\u0148uj\u00EDc\u00ED farmakologick\u00FD efekt. Prol\u00E9\u010Diva jsou inaktivn\u00ED deriv\u00E1ty aktivn\u00EDch substanc\u00ED, kter\u00E9 mus\u00ED podl\u00E9hat enzymatick\u00E9 nebo chemick\u00E9 transformaci in vivo, aby se z nich uvolnilo mate\u0159sk\u00E9 l\u00E9\u010Divo s po\u017Eadovan\u00FDm farmakodynamick\u00FDm efektem. Prol\u00E9\u010Diva mohou b\u00FDt klasifikov\u00E1na jako nosi\u010Dov\u00E1 prol\u00E9\u010Diva nebo bioprekurzory. Nosi\u010Dov\u00E1 prol\u00E9\u010Diva jsou jednoduch\u00E9 chemick\u00E9 deriv\u00E1ty, kter\u00E9 jsou jedn\u00EDm nebo dv\u011Bma kroky p\u0159evedeny na mate\u0159sk\u00E9 l\u00E9\u010Divo. Bioprekurzory vy\u017Eaduj\u00ED biotransforma\u010Dn\u00ED enzymy pro aktivaci; jejich aktivace je v\u00FDsledkem metabolick\u00FDch reakc\u00ED zahrnuj\u00EDc\u00ED oxida\u010Dn\u00ED/reduk\u010Dn\u00ED procesy. Tak\u00E9 zdvojen\u00E1 l\u00E9\u010Diva jsou \u00FA\u010Dinn\u00FDm n\u00E1strojem optimalizace l\u00E9\u010Div. Rovn\u011B\u017E tzv. soft drugs (l\u00E9\u010Diva s \u0159\u00EDzen\u00FDm metabolismem) jsou stru\u010Dn\u011B zm\u00EDn\u011Bna pro objasn\u011Bn\u00ED jejich odli\u0161nosti od prol\u00E9\u010Div"@cs . . . "Chemick\u00E9 listy" . . "2"^^ . . "Strukturn\u00ED modifikace l\u00E9\u010Div ovliv\u0148uj\u00EDc\u00ED biodostupnost a terapeutick\u00FD \u00FA\u010Dinek"@cs . "Strukturn\u00ED modifikace l\u00E9\u010Div ovliv\u0148uj\u00EDc\u00ED biodostupnost a terapeutick\u00FD \u00FA\u010Dinek" . "Prodrugs are inactive derivatives of active drug substances which, on undergoing an enzymatic or chemical transformation in vivo, release the active parent drug that can then elicit the desired pharmacodynamic effect. Prodrugs can be classified into carrier prodrugs and bioprecursors. In most cases, carrier prodrugs are simple chemical derivatives of compounds that are only one or two chemical or enzymatic steps away from the active parent drug. Bioprecursors require enzymes of biotransformation phases for their activation; the active species results from a cascade of metabolic reactions involving oxidative/ reductive processes. Currently codrugs (mutual prodrugs) become an efficient approach to drug optimization. The soft drug approach is briefly mentioned to clarify the difference between soft drugs and prodrugs."@en . "2"^^ . "48026" . "Strukturn\u00ED modifikace l\u00E9\u010Div ovliv\u0148uj\u00EDc\u00ED biodostupnost a terapeutick\u00FD \u00FA\u010Dinek"@cs . "classification; soft drugs; doubled drugs; bioprecursors; prodrugs"@en . . . "CZ - \u010Cesk\u00E1 republika" . "1" . "Structure Modification of Drugs or Prodrugs Influencing Their Bioavailability and Therapeutic Effect"@en . . . "000331796000003" . "Strukturn\u00ED modifikace l\u00E9\u010Div ovliv\u0148uj\u00EDc\u00ED biodostupnost a terapeutick\u00FD \u00FA\u010Dinek" . "16370" . "Structure Modification of Drugs or Prodrugs Influencing Their Bioavailability and Therapeutic Effect"@en .