"2"^^ . "Wojnarov\u00E1, Lenka" . "Carboxymethyl cellulose, especially the sodium salt, is a versatile pharmaceutical excipient. From a therapeutic point of view, sodium salt of carboxymethyl cellulose is used in the production of modern wound dressings to allow moist wound healing. Wound dressing must be sterile and stable throughout its shelf life and it has to be able to withstand different temperature conditions. At present time, number of sterilization methods is available. In the case of polymeric materials, selected sterilization process must not induce any changes in the polymer structure, such as polymer chains cleavage, changes in cross-linking, etc. This paper evaluates the influence of different sterilization methods (gamma radiation, beta radiation, ethylene oxide) on the stability of carboxymethyl cellulose and results of long-term and accelerated stability testing. Evaluation of samples was performed using a size-exclusion chromatography. The obtained results showed that the ethylene oxide sterilization was the least aggressive variant of the tested sterilization methods. When the gamma radiation sterilization was used, the changes in the size of the carboxymethyl cellulose molecule occurred. In the course of accelerated and long term stability studies, no further degradation changes were observed, and thus sterilized samples are suitable for long term storage."@en . "Musel\u00EDk, Jan" . . . "4"^^ . "RIV/62157124:16370/13:43872208" . "size exclusion chromatography; stability testing; sterilization; carboxymethyl cellulose"@en . . "Hodnocen\u00ED vlivu steriliza\u010Dn\u00ED metody na stabilitu karboxymethylcelulosov\u00E9ho kryt\u00ED na r\u00E1ny" . . "77886" . "Sopuch, Tom\u00E1\u0161" . "16370" . "Evaluation of the influence of sterilization method on the stability Evaluation of the influence of sterilization method on the stability of carboxymethyl cellulose wound dressing"@en . . "Karboxymethylcelulosa, hlavn\u011B jej\u00ED sodn\u00E1 s\u016Fl maj\u00ED v podob\u011B pomocn\u00FDch l\u00E1tek mnohostrann\u00E9 vyu\u017Eit\u00ED ve farmacii. Z terapeutick\u00E9ho hlediska se sodn\u00E1 s\u016Fl karboxymethylcelulosy uplat\u0148uje ve v\u00FDrob\u011B modern\u00EDch kryt\u00ED na r\u00E1ny umo\u017E\u0148uj\u00EDc\u00EDch vlhk\u00E9 hojen\u00ED. Kryt\u00ED na r\u00E1ny mus\u00ED b\u00FDt steriln\u00ED a stabiln\u00ED po celou dobu pou\u017Eitelnosti p\u0159i uchov\u00E1v\u00E1n\u00ED za r\u016Fzn\u00FDch teplotn\u00EDch podm\u00EDnek. V sou\u010Dasn\u00E9 dob\u011B je k dispozici \u0159ada steriliza\u010Dn\u00EDch metod. V p\u0159\u00EDpad\u011B polymern\u00EDch l\u00E1tek je d\u016Fle\u017Eit\u00E9, aby zvolen\u00FD postup sterilizace nevyvol\u00E1val zm\u011Bny ve struktu\u0159e polymeru, jako \u0161t\u011Bpen\u00ED polymern\u00EDch \u0159et\u011Bzc\u016F, zm\u011Bny zes\u00EDt\u011Bn\u00ED apod. Tato pr\u00E1ce hodnot\u00ED vliv r\u016Fzn\u00FDch steriliza\u010Dn\u00EDch metod (gama z\u00E1\u0159en\u00ED, beta z\u00E1\u0159en\u00ED, ethylenoxid) na stabilitu karboxymethylcelulosy a d\u00E1le stabilitu v podm\u00EDnk\u00E1ch zrychlen\u00E9 a dlouhodob\u00E9 stabilitn\u00ED studie. Hodnocen\u00ED vzork\u016F je provedeno s vyu\u017Eit\u00EDm rozm\u011Brov\u011B vylu\u010Dovac\u00ED chromatografie. Z dosa\u017Een\u00FDch v\u00FDsledk\u016F vypl\u00FDv\u00E1, \u017Ee sterilizace ethylenoxidem p\u0159edstavuje nej\u0161etrn\u011Bj\u0161\u00ED variantu z testovan\u00FDch zp\u016Fsob\u016F sterilizace. V p\u0159\u00EDpad\u011B pou\u017Eit\u00ED sterilizace gama z\u00E1\u0159en\u00EDm doch\u00E1zelo ke zm\u011Bn\u00E1m velikosti molekuly karboxymethylcelulosy. V pr\u016Fb\u011Bhu zrychlen\u00E9 a dlouhodob\u00E9 stabilitn\u00ED studie, ale nebyly dal\u0161\u00ED degrada\u010Dn\u00ED zm\u011Bny pozorov\u00E1ny a takto sterilizovan\u00E9 vzorky jsou vhodn\u00E9 pro dlouhodob\u00E9 skladov\u00E1n\u00ED." . . . "1210-7816" . "Hodnocen\u00ED vlivu steriliza\u010Dn\u00ED metody na stabilitu karboxymethylcelulosov\u00E9ho kryt\u00ED na r\u00E1ny"@cs . . . "CZ - \u010Cesk\u00E1 republika" . "RIV/62157124:16370/13:43872208!RIV14-TA0-16370___" . . . "2" . "[239C640B4083]" . . . "Hodnocen\u00ED vlivu steriliza\u010Dn\u00ED metody na stabilitu karboxymethylcelulosov\u00E9ho kryt\u00ED na r\u00E1ny" . "P(TA01010244)" . . "Evaluation of the influence of sterilization method on the stability Evaluation of the influence of sterilization method on the stability of carboxymethyl cellulose wound dressing"@en . . "Hodnocen\u00ED vlivu steriliza\u010Dn\u00ED metody na stabilitu karboxymethylcelulosov\u00E9ho kryt\u00ED na r\u00E1ny"@cs . "62" . . "\u010Cesk\u00E1 a slovensk\u00E1 farmacie" . "Masteikov\u00E1, Ruta" . . "4"^^ . "Karboxymethylcelulosa, hlavn\u011B jej\u00ED sodn\u00E1 s\u016Fl maj\u00ED v podob\u011B pomocn\u00FDch l\u00E1tek mnohostrann\u00E9 vyu\u017Eit\u00ED ve farmacii. Z terapeutick\u00E9ho hlediska se sodn\u00E1 s\u016Fl karboxymethylcelulosy uplat\u0148uje ve v\u00FDrob\u011B modern\u00EDch kryt\u00ED na r\u00E1ny umo\u017E\u0148uj\u00EDc\u00EDch vlhk\u00E9 hojen\u00ED. Kryt\u00ED na r\u00E1ny mus\u00ED b\u00FDt steriln\u00ED a stabiln\u00ED po celou dobu pou\u017Eitelnosti p\u0159i uchov\u00E1v\u00E1n\u00ED za r\u016Fzn\u00FDch teplotn\u00EDch podm\u00EDnek. V sou\u010Dasn\u00E9 dob\u011B je k dispozici \u0159ada steriliza\u010Dn\u00EDch metod. V p\u0159\u00EDpad\u011B polymern\u00EDch l\u00E1tek je d\u016Fle\u017Eit\u00E9, aby zvolen\u00FD postup sterilizace nevyvol\u00E1val zm\u011Bny ve struktu\u0159e polymeru, jako \u0161t\u011Bpen\u00ED polymern\u00EDch \u0159et\u011Bzc\u016F, zm\u011Bny zes\u00EDt\u011Bn\u00ED apod. Tato pr\u00E1ce hodnot\u00ED vliv r\u016Fzn\u00FDch steriliza\u010Dn\u00EDch metod (gama z\u00E1\u0159en\u00ED, beta z\u00E1\u0159en\u00ED, ethylenoxid) na stabilitu karboxymethylcelulosy a d\u00E1le stabilitu v podm\u00EDnk\u00E1ch zrychlen\u00E9 a dlouhodob\u00E9 stabilitn\u00ED studie. Hodnocen\u00ED vzork\u016F je provedeno s vyu\u017Eit\u00EDm rozm\u011Brov\u011B vylu\u010Dovac\u00ED chromatografie. Z dosa\u017Een\u00FDch v\u00FDsledk\u016F vypl\u00FDv\u00E1, \u017Ee sterilizace ethylenoxidem p\u0159edstavuje nej\u0161etrn\u011Bj\u0161\u00ED variantu z testovan\u00FDch zp\u016Fsob\u016F sterilizace. V p\u0159\u00EDpad\u011B pou\u017Eit\u00ED sterilizace gama z\u00E1\u0159en\u00EDm doch\u00E1zelo ke zm\u011Bn\u00E1m velikosti molekuly karboxymethylcelulosy. V pr\u016Fb\u011Bhu zrychlen\u00E9 a dlouhodob\u00E9 stabilitn\u00ED studie, ale nebyly dal\u0161\u00ED degrada\u010Dn\u00ED zm\u011Bny pozorov\u00E1ny a takto sterilizovan\u00E9 vzorky jsou vhodn\u00E9 pro dlouhodob\u00E9 skladov\u00E1n\u00ED."@cs . .