. . . . "5"^^ . . . . "[B303751C15F9]" . "62" . "6" . "Kr\u00E1lov\u00E1, Michaela" . "Sledov\u00E1n\u00ED vzniku hydr\u00E1t\u016F diklofenaku sodn\u00E9 soli a jejich vlivu na disoluci l\u00E9\u010Diva z p\u0159ipraven\u00FDch tablet" . "RIV/62157124:16370/13:43872204!RIV14-MSM-16370___" . "CZ - \u010Cesk\u00E1 republika" . "4"^^ . . "1210-7816" . "S" . . . "3"^^ . "Sledov\u00E1n\u00ED vzniku hydr\u00E1t\u016F diklofenaku sodn\u00E9 soli a jejich vlivu na disoluci l\u00E9\u010Diva z p\u0159ipraven\u00FDch tablet"@cs . . . . "105563" . "Musel\u00EDk, Jan" . . "Sledov\u00E1n\u00ED vzniku hydr\u00E1t\u016F diklofenaku sodn\u00E9 soli a jejich vlivu na disoluci l\u00E9\u010Diva z p\u0159ipraven\u00FDch tablet" . . "process analytical technology method, PLS regression, NIR spectroscopy, hydrates, impregnation, diclofenac sodium"@en . "NIR spektroskopie spole\u010Dn\u011B s v\u00EDcerozm\u011Brnou anal\u00FDzou dat se pou\u017Eila k anal\u00FDze hydr\u00E1t\u016F diklofenaku sodn\u00E9 soli p\u0159ipraven\u00FDch z nevodn\u00FDch rozpou\u0161t\u011Bdel tetrahydrofuranu a methanolu za standardn\u00EDch laboratorn\u00EDch podm\u00EDnek p\u0159i 20\u00B0C a RH{60%. Potvrdilo se, \u017Ee pomoc\u00ED vyvinut\u00E9ho PLS regresn\u00EDho modelu lze sledovat proces vzniku hydr\u00E1t\u016F. D\u00E1le se zjistilo, \u017Ee p\u0159i p\u0159\u00EDprav\u011B l\u00E9kov\u00E9 formy vyu\u017E\u00EDvaj\u00EDc\u00ED impregnaci na pevn\u00FD nosi\u010D z nevodn\u00FDch rozpou\u0161t\u011Bdel vznik\u00E1 hydratovan\u00E1 forma diklofenaku sodn\u00E9 soli, co\u017E se v\u00FDsledn\u011B projevuje a\u017E dvojn\u00E1sobn\u00FDm zpomalen\u00EDm uvol\u0148ov\u00E1n\u00ED l\u00E9\u010Diva z tablet. NIR spektroskopie se zde potvrdila jako jedna z \u00FA\u010Dinn\u00FDch PAT (process analytical technology) metod." . "\u010Cesk\u00E1 a slovensk\u00E1 farmacie" . "Monitoring of formation of diclofenac sodium salt hydrates and their influence on the drug dissolution from prepared tablets"@en . "NIR spectroscopy together with multivariate data analysis were used to analyze the hydrates of diclofenac sodium prepared from non-aqueous solvent of tetrahydrofuran and methanol under standard laboratory conditions at 20 \u00B0C and relative humidity less than 60%. It was confirmed that the developed PLS regression model can monitor the process of formation of hydrates. It was also found that hydrated form of diclofenac sodium arises during the preparation of the medical form using technology of impregnating the solid carrier by non-aqueous solvents, which resulted in reducing of the drug release rate from prepared tablets up to twice. NIR spectroscopy was confirmed as one of the effective PAT (Process Analytical Technology) methods."@en . "RIV/62157124:16370/13:43872204" . "Sledov\u00E1n\u00ED vzniku hydr\u00E1t\u016F diklofenaku sodn\u00E9 soli a jejich vlivu na disoluci l\u00E9\u010Diva z p\u0159ipraven\u00FDch tablet"@cs . "Monitoring of formation of diclofenac sodium salt hydrates and their influence on the drug dissolution from prepared tablets"@en . . . "Dole\u017Eel, Petr" . "Vetch\u00FD, David" . "16370" . . . . "NIR spektroskopie spole\u010Dn\u011B s v\u00EDcerozm\u011Brnou anal\u00FDzou dat se pou\u017Eila k anal\u00FDze hydr\u00E1t\u016F diklofenaku sodn\u00E9 soli p\u0159ipraven\u00FDch z nevodn\u00FDch rozpou\u0161t\u011Bdel tetrahydrofuranu a methanolu za standardn\u00EDch laboratorn\u00EDch podm\u00EDnek p\u0159i 20\u00B0C a RH{60%. Potvrdilo se, \u017Ee pomoc\u00ED vyvinut\u00E9ho PLS regresn\u00EDho modelu lze sledovat proces vzniku hydr\u00E1t\u016F. D\u00E1le se zjistilo, \u017Ee p\u0159i p\u0159\u00EDprav\u011B l\u00E9kov\u00E9 formy vyu\u017E\u00EDvaj\u00EDc\u00ED impregnaci na pevn\u00FD nosi\u010D z nevodn\u00FDch rozpou\u0161t\u011Bdel vznik\u00E1 hydratovan\u00E1 forma diklofenaku sodn\u00E9 soli, co\u017E se v\u00FDsledn\u011B projevuje a\u017E dvojn\u00E1sobn\u00FDm zpomalen\u00EDm uvol\u0148ov\u00E1n\u00ED l\u00E9\u010Diva z tablet. NIR spektroskopie se zde potvrdila jako jedna z \u00FA\u010Dinn\u00FDch PAT (process analytical technology) metod."@cs .