. . "Eight hydrochlorides of 3-{2-[(2/4-flurophenoxy)-ethylamino]}-2-hydroxypropyl-4-alkoxybenzoates and four hydrochlorides of 3-tert-butylamino-2-hydroxypropyl-4-butoxybenzoates were prepared as potential antagonists of the beta 1-adrenergic receptor (beta-blockers). A multistep synthesis of these compounds is described as well as their detailed analytical characterization. The pharmacokinetic properties of these weak base compounds are significantly influenced by their acid-base dissociation constant, pK(a). The knowledge of this value is crucial for new drug development. This paper is aimed at developing a methodology that utilizes pH-dependent H-1 NMR spectroscopy for its routine analysis. The selected predicted physico-chemical parameters of the new (arylcarbonyloxy)aminopropanols (i.e., aryloxyaminopropanol derivatives) were compared with the model drugs esmolol and flestolol."@en . . . . "000324816000006" . . . "Stropnick\u00FD, Ond\u0159ej" . "Kapust\u00EDkov\u00E1, Iva" . "7"^^ . . . . . "Ultrashort effect; H-1 NMR spectroscopy; Acid dissociation constant; Beta-blockers; Aryloxyaminopropanol"@en . "RIV/62157124:16370/13:43872136" . "109539" . "Synthesis of new (arylcarbonyloxy)aminopropanol derivatives and the determination of their physico-chemical properties"@en . "5"^^ . "Synthesis of new (arylcarbonyloxy)aminopropanol derivatives and the determination of their physico-chemical properties"@en . "11" . . "[3B543423393A]" . "Tengler, Jan" . "Synthesis of new (arylcarbonyloxy)aminopropanol derivatives and the determination of their physico-chemical properties" . "16370" . "10.2478/s11532-013-0302-8" . "Synthesis of new (arylcarbonyloxy)aminopropanol derivatives and the determination of their physico-chemical properties" . "Eight hydrochlorides of 3-{2-[(2/4-flurophenoxy)-ethylamino]}-2-hydroxypropyl-4-alkoxybenzoates and four hydrochlorides of 3-tert-butylamino-2-hydroxypropyl-4-butoxybenzoates were prepared as potential antagonists of the beta 1-adrenergic receptor (beta-blockers). A multistep synthesis of these compounds is described as well as their detailed analytical characterization. The pharmacokinetic properties of these weak base compounds are significantly influenced by their acid-base dissociation constant, pK(a). The knowledge of this value is crucial for new drug development. This paper is aimed at developing a methodology that utilizes pH-dependent H-1 NMR spectroscopy for its routine analysis. The selected predicted physico-chemical parameters of the new (arylcarbonyloxy)aminopropanols (i.e., aryloxyaminopropanol derivatives) were compared with the model drugs esmolol and flestolol." . . . . . "Mokr\u00FD, Petr" . "11"^^ . . "11" . "I, P(ED1.1.00/02.0073), S" . . . "1895-1066" . . "Cs\u00F6llei, Jozef" . . "PL - Polsk\u00E1 republika" . . "Oravec, Michal" . "RIV/62157124:16370/13:43872136!RIV14-MSM-16370___" . "Jamp\u00EDlek, Josef" . . . "Central European Journal of Chemistry" .