"Prostatick\u00E9 specifick\u00E9 antigeny, metallothionein a Caveolin-1 jako markery vzniku a v\u00FDvoje karcinomu prostaty" . . "Cernei, Natalia" . . "[6AE63A744FEB]" . . "Prostatick\u00E9 specifick\u00E9 antigeny, metallothionein a Caveolin-1 jako markery vzniku a v\u00FDvoje karcinomu prostaty" . "The current diagnostic limitations of prostate cancer have shown that the development of new approaches to early detection of aggressive forms of of the cancer is very important. A comprehensive approach to detection of potential tumour markers using different methods and their optimization is described. We focused on caveolin-1 and metallothionein and the obtained results were compared with prostate specific antigen as a golden standard of prostate cancer markers. All the mentioned markers were detected on both the mRNA and protein levels in three types of prostate cell lines. Metallothionein and caveolin-1 rank among the promising markers in prostate cancer diagnosis, especially. for distinguishing aggressive silent forms of the disease."@en . "RIV/62157124:16370/12:43871285!RIV13-MSM-16370___" . "106" . "RIV/62157124:16370/12:43871285" . "000311583300010" . . "Z\u00EDtka, Ond\u0159ej" . . "11" . "I" . . "Sou\u010Dasn\u00E1 diagnostick\u00E1 omezen\u00ED zhoubn\u00FDch n\u00E1dor\u016F prostaty poukazuj\u00ED na nutnost v\u00FDvoje nov\u00FDch postup\u016F k \u010Dasn\u00E9mu odhalen\u00ED agresivn\u00EDch forem tohoto onemocn\u011Bn\u00ED. Tato pr\u00E1ce popisuje komplexn\u00ED p\u0159\u00EDstup k detekci potenci\u00E1ln\u00EDch n\u00E1dorov\u00FDch marker\u016F s vyu\u017Eit\u00EDm rozd\u00EDln\u00FDch metod a s jejich optimalizac\u00ED. Nad\u011Bjn\u00FDmi geny jsou metalothionein a caveolin-1. Metalothionein d\u00EDky jeho unik\u00E1tn\u00ED struktu\u0159e byl detegov\u00E1n za u\u017Eit\u00ED separace pomoc\u00ED paramagnetick\u00FDch \u010D\u00E1stic a n\u00E1sledn\u00E9 elektrochemick\u00E9 detekce. Metalothionein i caveolin-1 vykazuj\u00ED stejn\u00E9 trendy na \u00FArovni mRNA a proteinu - sn\u00ED\u017Een\u00ED hladiny u prim\u00E1rn\u00EDho n\u00E1doru a v\u00FDrazn\u00E9 zv\u00FD\u0161en\u00ED u metastatick\u00E9 linie PC-3. Oba geny jsou tedy signifikantn\u011B zv\u00FD\u0161eny a\u017E u agresivn\u00ED formy onemocn\u011Bn\u00ED. Praktickou pou\u017Eitelnost je nutn\u00E9 ov\u011B\u0159it studiemi na re\u00E1ln\u00FDch bioptick\u00FDch vzorc\u00EDch." . "Sztalmachov\u00E1, Mark\u00E9ta" . "Prostatick\u00E9 specifick\u00E9 antigeny, metallothionein a Caveolin-1 jako markery vzniku a v\u00FDvoje karcinomu prostaty"@cs . "0009-2770" . . "1"^^ . "Hlavna, Marian" . "Babula, Petr" . . . "Prostatick\u00E9 specifick\u00E9 antigeny, metallothionein a Caveolin-1 jako markery vzniku a v\u00FDvoje karcinomu prostaty"@cs . "Kizek, Ren\u00E9" . . "Prostate Specific Antigen, Metallothionein and Caveolin-1 as Markers of Formation and Development of Prostate Carcinom"@en . . "16370" . "6"^^ . "9"^^ . "CZ - \u010Cesk\u00E1 republika" . . "162971" . "prostate specific antigen; caveolin-1; metallothionein; prostate carcinom"@en . . "Sou\u010Dasn\u00E1 diagnostick\u00E1 omezen\u00ED zhoubn\u00FDch n\u00E1dor\u016F prostaty poukazuj\u00ED na nutnost v\u00FDvoje nov\u00FDch postup\u016F k \u010Dasn\u00E9mu odhalen\u00ED agresivn\u00EDch forem tohoto onemocn\u011Bn\u00ED. Tato pr\u00E1ce popisuje komplexn\u00ED p\u0159\u00EDstup k detekci potenci\u00E1ln\u00EDch n\u00E1dorov\u00FDch marker\u016F s vyu\u017Eit\u00EDm rozd\u00EDln\u00FDch metod a s jejich optimalizac\u00ED. Nad\u011Bjn\u00FDmi geny jsou metalothionein a caveolin-1. Metalothionein d\u00EDky jeho unik\u00E1tn\u00ED struktu\u0159e byl detegov\u00E1n za u\u017Eit\u00ED separace pomoc\u00ED paramagnetick\u00FDch \u010D\u00E1stic a n\u00E1sledn\u00E9 elektrochemick\u00E9 detekce. Metalothionein i caveolin-1 vykazuj\u00ED stejn\u00E9 trendy na \u00FArovni mRNA a proteinu - sn\u00ED\u017Een\u00ED hladiny u prim\u00E1rn\u00EDho n\u00E1doru a v\u00FDrazn\u00E9 zv\u00FD\u0161en\u00ED u metastatick\u00E9 linie PC-3. Oba geny jsou tedy signifikantn\u011B zv\u00FD\u0161eny a\u017E u agresivn\u00ED formy onemocn\u011Bn\u00ED. Praktickou pou\u017Eitelnost je nutn\u00E9 ov\u011B\u0159it studiemi na re\u00E1ln\u00FDch bioptick\u00FDch vzorc\u00EDch."@cs . . "Chemick\u00E9 listy" . . "Masa\u0159\u00EDk, Michal" . . "Adam, Vojt\u011Bch" . "Gumulec, Jarom\u00EDr" . "Prostate Specific Antigen, Metallothionein and Caveolin-1 as Markers of Formation and Development of Prostate Carcinom"@en .