. . . "0968-0896" . "128658" . "NL - Nizozemsko" . "Musiol, Robert" . "Jamp\u00EDlek, Josef" . "20" . "Nycz, Jacek E" . . . . "1"^^ . . "10.1016/j.bmc.2012.10.027" . "RIV/62157124:16370/12:43871087!RIV13-MSM-16370___" . "Contribution to investigation of antimicrobial activity of styrylquinolines" . . . . . "I, V" . . "16370" . "Contribution to investigation of antimicrobial activity of styrylquinolines" . "Polanski, Jaroslaw" . "8"^^ . "Series of new ring-substituted styrylquinolines and two oxorhenium complexes were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against fungal and bacterial strains. Some compounds were active against bacteria at micromolar level and against fungi at submicromolar level. Compounds 5,7-dichloro-2-[2-(2-ethoxyphenyl)vinyl]quinolin-8-ol expressed excellent antifungal activity comparable with or higher than the standard fluconazole as well as antibacterial activity against Staphylococcus strains comparable with or higher than the standards bacitracin, penicillin and ciprofloxacin. The structure-activity relationships are discussed. (C) 2012 Elsevier Ltd. All rights reserved." . "Wolff, Mariusz" . "24" . . "Contribution to investigation of antimicrobial activity of styrylquinolines"@en . "Structure-activity relationships; In vitro antibacterial activity; In vitro antifungal activity; Quinolines lipophilicity"@en . "[E0231D32C48B]" . . "Cieslik, Wioleta" . . "Machura, Barbara" . "000311421300007" . "Bioorganic and Medicinal Chemistry" . "Series of new ring-substituted styrylquinolines and two oxorhenium complexes were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against fungal and bacterial strains. Some compounds were active against bacteria at micromolar level and against fungi at submicromolar level. Compounds 5,7-dichloro-2-[2-(2-ethoxyphenyl)vinyl]quinolin-8-ol expressed excellent antifungal activity comparable with or higher than the standard fluconazole as well as antibacterial activity against Staphylococcus strains comparable with or higher than the standards bacitracin, penicillin and ciprofloxacin. The structure-activity relationships are discussed. (C) 2012 Elsevier Ltd. All rights reserved."@en . "Vej\u0161ov\u00E1, Marcela" . "Contribution to investigation of antimicrobial activity of styrylquinolines"@en . "RIV/62157124:16370/12:43871087" . "9"^^ . . .