. . "7"^^ . . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Tr\u00E1vn\u00ED\u010Dek, Zden\u011Bk" . "The gold(I) complexes of the general formula [Au(Ln)(PPh3)]?xH2O (1?8; n = 1?8 and x = 0?1.5), where Ln stands for a deprotonated form of the benzyl-substituted derivatives of 6-benzylaminopurine, were prepared, thoroughly characterized (elemental analyses, FT-IR, Raman and multinuclear NMR spectroscopy, ESI+ mass spectrometry, conductivity, DFT calculations), and studied for their in vitro cytotoxicity and in vitro and in vivo anti-inflammatory effects on LPS-activated macrophages (derived from THP-1 cell line) and using the carrageenan-induced hind paw edema model on rats. The obtained results indicate that the representative complexes (1, 3, 6) exhibit a strong ability to reduce the production of pro-inflammatory cytokines TNF-alfa, IL-1beta and HMGB1 without influence on the secretion of anti-inflammatory cytokine IL-1RA in the LPSactivated.macrophages. The complexes also significantly influence the formation of edema, caused by the intraplantar application of polysaccharide lambda-carrageenan to rats in vivo. All the tested complexes showed similar or better biological effects as compared with Auranofin, but contrary to Auranofin they were found to be less cytotoxic in vitro. The obtained results clearly indicate that the gold(I) complexes behave as very effective anti-inflammatory agents and could prove to be useful for the treatment of difficult to treat inflammatory diseases such as rheumatoid arthritis." . "0022-2623" . . "10" . "55" . "Anti-inflammatory Active Gold(I) Complexes Involving 6-Substituted-Purine Derivatives" . "6-benzylaminopurine; pro-inflammatory cytokines; Gold Complexes"@en . . "10.1021/jm201416p" . "Ho\u0161ek, Jan" . "12"^^ . "The gold(I) complexes of the general formula [Au(Ln)(PPh3)]?xH2O (1?8; n = 1?8 and x = 0?1.5), where Ln stands for a deprotonated form of the benzyl-substituted derivatives of 6-benzylaminopurine, were prepared, thoroughly characterized (elemental analyses, FT-IR, Raman and multinuclear NMR spectroscopy, ESI+ mass spectrometry, conductivity, DFT calculations), and studied for their in vitro cytotoxicity and in vitro and in vivo anti-inflammatory effects on LPS-activated macrophages (derived from THP-1 cell line) and using the carrageenan-induced hind paw edema model on rats. The obtained results indicate that the representative complexes (1, 3, 6) exhibit a strong ability to reduce the production of pro-inflammatory cytokines TNF-alfa, IL-1beta and HMGB1 without influence on the secretion of anti-inflammatory cytokine IL-1RA in the LPSactivated.macrophages. The complexes also significantly influence the formation of edema, caused by the intraplantar application of polysaccharide lambda-carrageenan to rats in vivo. All the tested complexes showed similar or better biological effects as compared with Auranofin, but contrary to Auranofin they were found to be less cytotoxic in vitro. The obtained results clearly indicate that the gold(I) complexes behave as very effective anti-inflammatory agents and could prove to be useful for the treatment of difficult to treat inflammatory diseases such as rheumatoid arthritis."@en . "16370" . . . "Journal of medicinal chemistry" . "RIV/62157124:16370/12:43871074" . "RIV/62157124:16370/12:43871074!RIV13-MSM-16370___" . "Anti-inflammatory Active Gold(I) Complexes Involving 6-Substituted-Purine Derivatives"@en . . . "Van\u010Do, J\u00E1n" . . . "122954" . . "Such\u00FD, Pavel" . . . "Pra\u017Eanov\u00E1, Gabriela" . . . . . "Anti-inflammatory Active Gold(I) Complexes Involving 6-Substituted-Purine Derivatives" . . "3"^^ . "\u0160tarha, Pavel" . "I, P(ED2.1.00/03.0058), P(EE2.3.20.0017), S, Z(MSM6198959218)" . "Anti-inflammatory Active Gold(I) Complexes Involving 6-Substituted-Purine Derivatives"@en . . "\u0160ilha, Tom\u00E1\u0161" . "[2F235A618BDF]" . . "000304338800004" . .