. "Gali\u0161inov\u00E1, Jana" . "CZ - \u010Cesk\u00E1 republika" . "2"^^ . . "[57F72904E8EA]" . . "7"^^ . "Analytick\u00E9 hodnotenie mono[{3-[4-(2-etoxyetoxy)-benzoyloxy]-2-hydroxypropyl}-tert-butylamm\u00F3nium]fumar\u00E1tu" . "V" . . "The present paper aims at a complex spectral and physicochemical evaluation of mono[{3-[4-(2-ethoxyethoxy)-benzoyloxy]-2-hydroxypropyl}-tert-butylammonium] fumarate, the potential ultra-short acting blocker of \u00DF1-adrenergic receptors. The identity of the evaluated compound (labelled as UPB-2) was confirmed by 1H-, 13C-NMR and IR spectral data as well. The estimated physicochemical parameters included melting point data, solubility in variol media, purity checking (adsorption thin-layer chromatography), surface activity determination (non-direct Traube stalagmometric method), acidobasic characteristics (pKa value determination by alkalimetric titration), log epsilon values estimation (spectrophotometrically in UV/VIS region) and a study of the influence of acidic and alkaline media towards the stability of UPB-2. Other experimentally estimated values were lipohydrophilic descriptors using RP- HPLC (log k') and the log Pexps in variol lipohydrophilic media by the shake flask method. Based on the log Pexp readouts, the ability to permeate across the brain-blood barrier was predicted. For the content determination of UBP-2 the RP-HPLC (reversed-phase HPLC), the method of an internal standard and UV/VIS spectrophotometry at the wavelength of 260 nm (aqueous medium) and at 258 nm (methanolic medium) was applied."@en . "Mal\u00EDk, Ivan" . "16370" . "Predmetom publik\u00E1cie je komplexn\u00E9 spektr\u00E1lne a fyzik\u00E1lno-chemick\u00E9 hodnotenie mono[{3-[4-(2-etoxyetoxy)-benzoyloxy]-2-hydroxypropyl}-terc-butylam\u00F3nium]fumar\u00E1tu, potenci\u00E1lneho ultrakr\u00E1tko p\u00F4sobiaceho blok\u00E1tora \u00DF1-adrenergn\u00FDch receptorov. Toto\u017Enos\u0165 hodnotenej zl\u00FA\u010Deniny (pracovne ozna\u010Denej ako UPB-2) bola potvrden\u00E1 1H-, 13C-NMR a IR spektrami. V r\u00E1mci stanovenia z\u00E1kladn\u00FDch fyzik\u00E1lno-chemick\u00FDch charakterist\u00EDk bola ur\u010Den\u00E1 hodnota teploty topenia, rozpustnos\u0165 v spektre rozp\u00FA\u0161\u0165adiel, \u010Distota (adsorp\u010Dn\u00E1 chromatografia na tenkej vrstve), povrchov\u00E1 aktivita (nepriama Traubeho stalagmometrick\u00E1 met\u00F3da), acidob\u00E1zick\u00E9 charakteristiky (hodnota pKa stanoven\u00E1 alkalimetrickou titr\u00E1ciou), hodnoty log epsilon (spektrofotometricky v UV/ /VIS oblasti), ako aj hodnotenie vplyvu kysl\u00E9ho a z\u00E1sadit\u00E9ho prostredia na stabilitu UPB-2. \u010Eal\u0161\u00EDmi experiment\u00E1lne stanoven\u00FDmi parametrami boli lipohydrofiln\u00E9 deskriptory ur\u010Den\u00E9 pomocou RP-HPLC (log k'), shake flask met\u00F3dou stanoven\u00E9 hodnoty rozde\u013Eovac\u00EDch koeficientov Pexp (resp. log Pexp) v r\u00F4znych rozde\u013Eovac\u00EDch syst\u00E9moch. Na z\u00E1klade log Pexp-\u00FAdajov bola predpovedan\u00E1 schopnos\u0165 UPB-2 prech\u00E1dza\u0165 cez hematoencefalick\u00FA bari\u00E9ru. Pre stanovenie obsahu UPB-2 bola aplikovan\u00E1 RP HPLC (reversed-phase HPLC) met\u00F3da vn\u00FAtorn\u00E9ho \u0161tandardu a UV/VIS spektrofotometria pri vlnovej d\u013A\u017Eke 260 nm (vodn\u00E9 prostredie) a 258 nm (prostredie metanolu)." . . "1-2" . "Mitterov\u00E1, Lenka" . . "Luk\u00E1\u010D, Milo\u0161" . . "RIV/62157124:16370/12:43871026" . "Mokr\u00FD, Petr" . . . . "content determinativ; spectral and physicochemical properties; analytical evaluation; \u00DF1-blockers"@en . "RIV/62157124:16370/12:43871026!RIV13-MSM-16370___" . "1210-7816" . "\u010Cesk\u00E1 a slovensk\u00E1 farmacie" . "8"^^ . "Analytical evaluation of mono[{3-[4-(2-etoxyetoxy)-benzoyloxy]-2-hydroxypropyl}-tert-butylammonium]fumarate"@en . "Cs\u00F6llei, Jozef" . . "Analytick\u00E9 hodnotenie mono[{3-[4-(2-etoxyetoxy)-benzoyloxy]-2-hydroxypropyl}-tert-butylamm\u00F3nium]fumar\u00E1tu" . . "122350" . "Analytical evaluation of mono[{3-[4-(2-etoxyetoxy)-benzoyloxy]-2-hydroxypropyl}-tert-butylammonium]fumarate"@en . . "Andriamainty, Fils" . . "Karlovsk\u00E1, Janka" . . "61" . . .