. "Methods of pharmaceutical technology in preparation of pellets for detection of acetylcholinesterase inhibitors"@en . "150083" . . "5" . . "Tu\u0161arov\u00E1, Ivana" . "1210-7816" . "Methods of pharmaceutical technology in preparation of pellets for detection of acetylcholinesterase inhibitors"@en . . "Pro kontrolu p\u0159\u00EDtomnosti cizorod\u00FDch l\u00E1tek v ovzdu\u0161\u00ED je v sou\u010Dasn\u00E9 dob\u011B k dispozici cel\u00E1 \u0159ada metod a technick\u00FDch za\u0159\u00EDzen\u00ED. Obecn\u011B jsou v\u0161echny zn\u00E1m\u00E9 a propracovan\u00E9 metody zalo\u017Een\u00E9 na odb\u011Bru l\u00E1tek obsa\u017Een\u00FDch ve vzduchu pomoc\u00ED r\u016Fzn\u00FDch kolektor\u016F nebo vyu\u017E\u00EDvaj\u00ED jejich z\u00E1chyt do vhodn\u00E9ho prost\u0159ed\u00ED. St\u00E1le se v\u0161ak hledaj\u00ED nov\u00E9 metody detekce vyu\u017Eiteln\u00E9 zejm\u00E9na v ter\u00E9nn\u00EDch podm\u00EDnk\u00E1ch. Detek\u010Dn\u00ED syst\u00E9my mus\u00ED b\u00FDt p\u0159enosn\u00E9, rychle reaguj\u00EDc\u00ED, levn\u00E9, citliv\u00E9 a selektivn\u00ED a jejich obsluha by nem\u011Bla b\u00FDt slo\u017Eit\u00E1. Takov\u00FDmto vhodn\u00FDm syst\u00E9mem k detekci karbam\u00E1t\u016F a vysoce toxick\u00FDch organofosf\u00E1t\u016F jsou detek\u010Dn\u00ED trubi\u010Dky s peletami z mikrokrystalick\u00E9 celulosy s imobilizovanou acetylcholinesterasou, kter\u00FDmi je analyzovan\u00FD vzduch pros\u00E1v\u00E1n. Detekce je zalo\u017Eena na kolorimetrick\u00E9 Ellmanov\u011B reakci. Experiment\u00E1ln\u00ED pr\u00E1ce se zab\u00FDv\u00E1 vyu\u017Eit\u00EDm metod farmaceutick\u00E9 technologie pro p\u0159\u00EDpravu nov\u00FDch variant pelet pro detekci inhibitor\u016F acetylcholinesterasy s 20% a 50% obsahem anorganick\u00FDch plniv (oxid hlinit\u00FD, kaolin, koloidn\u00ED oxid k\u0159emi\u010Dit\u00FD, nalsit) metodou extruze/sferonizace. Po zhodnocen\u00ED jakostn\u00EDch parametr\u016F byly pelety naimpregnov\u00E1ny enzymem acetylcholinesterasou a u ka\u017Ed\u00E9 \u0161ar\u017Ee se zkou\u0161ela aktivita a inhibice pelet Ellmanov\u00FDm \u010Dinidlem. Vhodnou n\u00E1pln\u00ED detek\u010Dn\u00EDch trubi\u010Dek se jevily pelety bez obsahu anorganick\u00E9ho plniva, s obsahem 50 % oxidu hlinit\u00E9ho a s obsahem 20 % koloidn\u00EDho oxidu k\u0159emi\u010Dit\u00E9ho." . . "CZ - \u010Cesk\u00E1 republika" . . . . "Metody farmaceutick\u00E9 technologie v p\u0159\u00EDprav\u011B pelet pro detekci inhibitor\u016F acetylcholinesterasy" . "S" . "pellets, extrusion - spheronization, anorganic fillers, acetylcholinesterase inhibitors, detection tubes"@en . . "Metody farmaceutick\u00E9 technologie v p\u0159\u00EDprav\u011B pelet pro detekci inhibitor\u016F acetylcholinesterasy" . "Pro kontrolu p\u0159\u00EDtomnosti cizorod\u00FDch l\u00E1tek v ovzdu\u0161\u00ED je v sou\u010Dasn\u00E9 dob\u011B k dispozici cel\u00E1 \u0159ada metod a technick\u00FDch za\u0159\u00EDzen\u00ED. Obecn\u011B jsou v\u0161echny zn\u00E1m\u00E9 a propracovan\u00E9 metody zalo\u017Een\u00E9 na odb\u011Bru l\u00E1tek obsa\u017Een\u00FDch ve vzduchu pomoc\u00ED r\u016Fzn\u00FDch kolektor\u016F nebo vyu\u017E\u00EDvaj\u00ED jejich z\u00E1chyt do vhodn\u00E9ho prost\u0159ed\u00ED. St\u00E1le se v\u0161ak hledaj\u00ED nov\u00E9 metody detekce vyu\u017Eiteln\u00E9 zejm\u00E9na v ter\u00E9nn\u00EDch podm\u00EDnk\u00E1ch. Detek\u010Dn\u00ED syst\u00E9my mus\u00ED b\u00FDt p\u0159enosn\u00E9, rychle reaguj\u00EDc\u00ED, levn\u00E9, citliv\u00E9 a selektivn\u00ED a jejich obsluha by nem\u011Bla b\u00FDt slo\u017Eit\u00E1. Takov\u00FDmto vhodn\u00FDm syst\u00E9mem k detekci karbam\u00E1t\u016F a vysoce toxick\u00FDch organofosf\u00E1t\u016F jsou detek\u010Dn\u00ED trubi\u010Dky s peletami z mikrokrystalick\u00E9 celulosy s imobilizovanou acetylcholinesterasou, kter\u00FDmi je analyzovan\u00FD vzduch pros\u00E1v\u00E1n. Detekce je zalo\u017Eena na kolorimetrick\u00E9 Ellmanov\u011B reakci. Experiment\u00E1ln\u00ED pr\u00E1ce se zab\u00FDv\u00E1 vyu\u017Eit\u00EDm metod farmaceutick\u00E9 technologie pro p\u0159\u00EDpravu nov\u00FDch variant pelet pro detekci inhibitor\u016F acetylcholinesterasy s 20% a 50% obsahem anorganick\u00FDch plniv (oxid hlinit\u00FD, kaolin, koloidn\u00ED oxid k\u0159emi\u010Dit\u00FD, nalsit) metodou extruze/sferonizace. Po zhodnocen\u00ED jakostn\u00EDch parametr\u016F byly pelety naimpregnov\u00E1ny enzymem acetylcholinesterasou a u ka\u017Ed\u00E9 \u0161ar\u017Ee se zkou\u0161ela aktivita a inhibice pelet Ellmanov\u00FDm \u010Dinidlem. Vhodnou n\u00E1pln\u00ED detek\u010Dn\u00EDch trubi\u010Dek se jevily pelety bez obsahu anorganick\u00E9ho plniva, s obsahem 50 % oxidu hlinit\u00E9ho a s obsahem 20 % koloidn\u00EDho oxidu k\u0159emi\u010Dit\u00E9ho."@cs . "[708F19332AB1]" . "1"^^ . . "3"^^ . "16370" . "Vetch\u00FD, David" . "Metody farmaceutick\u00E9 technologie v p\u0159\u00EDprav\u011B pelet pro detekci inhibitor\u016F acetylcholinesterasy"@cs . "A variety of methods and technical equipment are currently available for checking of air contaminants. Generally, all known and sophisticated methods are based on sampling of substances in the air using different collectors or their capture in a suitable medium. Still, however, are looking for new detection methods useful particularly in outdoor conditions. Detection systems must be transportable, fast acting, inexpensive, sensitive and selective, and their operation should not be complicated. Such an appropriate system for the detection of carbamates and highly toxic organophosphates are detection tubes with microcrystalline cellulose pellets containing immobilized acetylcholinesterase, by which analyzed air is sucked through. The detection is based on the colorimetric Ellman reaction. Experimental work deals with the use of pharmaceutical technology methods for preparation of new variants of pellets for the detection of acetylcholinesterase inhibitors with 20% and 50% content of inorganic fillers (aluminium oxide, kaolin, colloidal silica, nalsit) produced by extrusion / spheronization. Pellets were impregnated by acetylcholinesterase after evaluating quality parameters and were tested for their activity and inhibition with Ellman's reagent. Pellets without inorganic fillers, containing 50% of aluminium oxide and containing 20% of colloidal silica were evaluated as suitable filling of detection tubes."@en . "\u010Cesk\u00E1 a slovensk\u00E1 farmacie" . . "RIV/62157124:16370/12:43871005" . "6"^^ . "Metody farmaceutick\u00E9 technologie v p\u0159\u00EDprav\u011B pelet pro detekci inhibitor\u016F acetylcholinesterasy"@cs . "RIV/62157124:16370/12:43871005!RIV13-MSM-16370___" . . . "61" . . . . . "Le\u0161tinov\u00E1, Hana" .