"I" . "Cs\u00F6llei, Jozef" . "Sedl\u00E1rov\u00E1, Eva" . . "RIV/62157124:16370/11:43870899!RIV12-MSM-16370___" . "Gali\u0161inov\u00E1, Jana" . "5"^^ . "Prediction of the blood-brain barrier permeation of 2-, 3-, 4-alkoxyphenylkarbamoic axcid derivatives with 4-(3-trifluormetylphenyl)piperazin-1-yl moiety forming part of the molecule"@en . "Predikcia schopnosti deriv\u00E1tov kyseliny 2-, 3-, 4-alkoxyfenylkarb\u00E1movej s b\u00E1zickou \u010Das\u0165ou tvorenou 4-(3-triflu\u00F3rmetylfenyl)piperaz\u00EDn-1-ylom prestupova\u0165 hematoencefalickou bari\u00E9rou" . "lipophilicity; blood-brain barrier; N-phenylpiperazine; phenylcarbamates; beta-blockers"@en . "5"^^ . "6" . . "Publik\u00E1cia nadv\u00E4dzuje na predch\u00E1zaj\u00FAce komplexn\u00E9 \u0161t\u00FAdium fyzik\u00E1lno-chemick\u00FDch vlastnost\u00ED 1-(3-triflu\u00F3rmetylfenyl)-4-[3-(2-,3-, a 4-alkoxyfenylkarbamouloxy)-2-hydroxypropyl]piperaz\u00EDniumchloridov s jedn\u00FDm a\u017E \u0161tyrmi atomami uhl\u00EDka v alkoxyskupine viazanej na aromatick\u00E9 jadro. Pre hodnoten\u00E9 \u0161trukt\u016Fry bol pod\u013Ea Younghovo, Kaliszanovho, Kelderovho, Clarkov\u00FDch, Panovho, Abrahamovho a Weathersbyho a Feherovho modelu geberovan\u00FD odhad ich schopnosti prestupova\u0165 hematoencafalickou bari\u00E9rou a tak vykazova\u0165, Resp. nevykazova\u0165 niektor\u00E9 ne\u017Eiad\u00FAce \u00FA\u010Dinky spojen\u00E9 so stimul\u00E1ciou centr\u00E1lneho nervov\u00E9ho syst\u00E9mu. Ako vypl\u00FDva z dosiahnut\u00FDch v\u00FDsledkov, \u0161tudovan\u00E9 zl\u00FA\u010Deniny zrejme nebud\u00FA pas\u00EDvnym sposobom permeova\u0165 cez BBB." . "Andriamanty, Fils" . . "RIV/62157124:16370/11:43870899" . "0014-8172" . "Mal\u00EDk, Ivan" . "16370" . . . "Prediction of the blood-brain barrier permeation of 2-, 3-, 4-alkoxyphenylkarbamoic axcid derivatives with 4-(3-trifluormetylphenyl)piperazin-1-yl moiety forming part of the molecule"@en . . . . . "SK - Slovensk\u00E1 republika" . . . . "80" . "[53F6A566C49D]" . "The present paper extends a complex physic-chemical study of 1-(3-trifluormethylphenyl)-4-[3-(2-,3-, and 4-alkoxyphenylkarbamoyloxy)-2-hydroxypropyl]piperaziniumchlorides with one to four carbon atoms in alkoxy group bonded at an aromatic ring. The studied compounds, according to obtained results, will assumedly not permeate across blood-brain barrier"@en . . . "222785" . "Predikcia schopnosti deriv\u00E1tov kyseliny 2-, 3-, 4-alkoxyfenylkarb\u00E1movej s b\u00E1zickou \u010Das\u0165ou tvorenou 4-(3-triflu\u00F3rmetylfenyl)piperaz\u00EDn-1-ylom prestupova\u0165 hematoencefalickou bari\u00E9rou" . . "Farmaceutick\u00FD obzor" . "1"^^ . . .