"2" . "Gali\u0161inov\u00E1, Jana" . "60" . . . . "16370" . . "CZ - \u010Cesk\u00E1 republika" . "Analytick\u00E9 hodnotenie mono[{3-[4-(2-etoxyetoxy)-benzoyloxy]-2-hydroxypropyl}-izopropylam\u00F3nium]fumar\u00E1tu" . "RIV/62157124:16370/11:43870770!RIV12-MSM-16370___" . "\u010Ci\u017Em\u00E1rik, Josef" . . . "Analytical evaluation of mono[{3-[4-(2-etoxyetoxy)-benzoyloxy]-2-hydroxypropyl}-isopropylamonium]fumarate"@en . . "Analytick\u00E9 hodnotenie mono[{3-[4-(2-etoxyetoxy)-benzoyloxy]-2-hydroxypropyl}-izopropylam\u00F3nium]fumar\u00E1tu" . "I" . "9"^^ . "Cs\u00F6llei, Jozef" . "Analytical evaluation of mono[{3-[4-(2-etoxyetoxy)-benzoyloxy]-2-hydroxypropyl}-isopropylamonium]fumarate"@en . "1210-7816" . "Andriamainty, Fils" . "Mal\u00EDk, Ivan" . . "Mokr\u00FD, Petr" . "Sedl\u00E1rov\u00E1, Eva" . "185878" . "2"^^ . . "RIV/62157124:16370/11:43870770" . . "content determination; spectral and physicochemical characteristic; analytic evaluation; \u00DF1-blockers"@en . . "Luk\u00E1\u010D, Milo\u0161" . . . . "10"^^ . "The present paper deals with a complex spectral and physicochemical evaluation of mono[{3-[4-(2-etoxyetoxy)-benzoyloxy]-2-hydroxypropyl}-isopropylammonium]fumarate, a potential ultrashort acting \u00DF1-blocker. The identity of the substance under study (labelled as UPB-1) was confirmed by 1H- and 13C-NMR spectra as well as IR spectrometry. The determined fundamental physicochemical characteristics included the determination of the melting point, solubility in a spectrum of solvents, verification of purity (adsorption thin-layer chromatography), determination of surface activity (Traube's stalagmometric method), acidobasic characteristics (pKa value by means of alkalimetric titration), determination of log epsilon values using spectrophotometry in UV/VIS region, as well as the evaluation of the effect of acid and basic media on the stability of the substance under the study. Other experimentally determined parameters were lipohydrophilic characteristics essayed by means of RP-HPLC (log k'), and the shake-flask method was employed to determine the values of the partition coefficients Pexp (resp. log Pexp) in different lipohydrophilic media. On the basis of log Pexp-data, the ability of the substance to penetrate the hematoencephalic barrier was predicted. To determine the UPB-1 content, RP-HPLC (reversed-phase HPLC) method of the internal standard and UV/VIS spectrophotometry at the wavelength of 260 nm (aqueous medium) and 258 nm (methanol medium) were used."@en . "[0A81E3A13425]" . . . . "\u010Cesk\u00E1 a slovensk\u00E1 farmacie" . "Predmetom prezentovanej pr\u00E1ce je komplexn\u00E9 spektr\u00E1lne a fyzik\u00E1lno-chemick\u00E9 hodnotenie mono[{3-[4-(2-etoxyetoxy)-benzoyloxy]-2-hydroxypropyl}-izopropylam\u00F3nium]fumar\u00E1tu, potenci\u00E1lneho ultrakr\u00E1tko p\u00F4sobiaceho \u00DF1-blok\u00E1tora. Toto\u017Enos\u0165 \u0161tudovanej substancie (pracovne ozna\u010Denej ako UPB-1) bola potvrden\u00E1 1H- a 13C-NMR spektrami ako aj IR spektrometriou. Medzi stanoven\u00E9 z\u00E1kladn\u00E9 fyzik\u00E1lno-chemick\u00E9 charakteristiky patrilo ur\u010Denie teploty topenia, rozpustnosti v spektre rozp\u00FA\u0161\u0165adiel, overenie \u010Distoty (adsorp\u010Dn\u00E1 chromatografia na tenkej vrstve), ur\u010Denie povrchovej aktivity (Traubeho stalagmometrick\u00E1 met\u00F3da), acidob\u00E1zick\u00E9 charakteristiky (hodnota pKa pomocou alkalimetrickej titr\u00E1cie), ur\u010Denie hodn\u00F4t log epsilon s vyu\u017Eit\u00EDm spektrofotometrie v UV/VIS oblasti, ako aj hodnotenie vplyvu kysl\u00E9ho a z\u00E1sadit\u00E9ho prostredia na stabilitu \u0161tudovanej l\u00E1tky. \u010Eal\u0161\u00EDmi experiment\u00E1lne stanoven\u00FDmi parametrami boli lipohydrofiln\u00E9 charakteristiky pomocou RP-HPLC (log k'), shake flask met\u00F3dou stanoven\u00E9 hodnoty rozde\u013Eovac\u00EDch koeficientov Pexp (resp. log Pexp) v r\u00F4znych lipohydrofiln\u00FDch prostrediach. Na z\u00E1klade log Pexp-d\u00E1t sa predikovala schopnos\u0165 l\u00E1tky prech\u00E1dza\u0165 cez hematoencefalick\u00FA bari\u00E9ru. Pre stanovenie obsahu UPB-1 sa pou\u017Eila RPHPLC (reversed-phase HPLC) met\u00F3da vn\u00FAtorn\u00E9ho \u0161tandardu a UV/VIS spektrofotometria pri vlnovej d\u013A\u017Eke 260 nm (vodn\u00E9 prostredie) a 258 nm (prostredie metanolu)." . "Karlovsk\u00E1, Janka" .