. "16370" . "\u0160t\u00FAdium hydrol\u00FDzy a stability niektor\u00FDch potenci\u00E1lnych betaadrenolyt\u00EDk met\u00F3dou chromatografie na tenkej vrstve" . "Stankovi\u010Dov\u00E1, M." . "I" . . . "SK - Slovensk\u00E1 republika" . "Mokr\u00FD, Petr" . . "5"^^ . . "The objective of the present study was to investigate the hydrolysis of arylcarboxyaminopropanol compounds with carbamate substitution on the benzene ring. These compounds are potential beta-adrenolytics with ultra-short effect. The studied compounds differ in the substitution on amino group in the side chain and in the carbamate group. The stability load test was carried out at two different temperatures in acidic and alkali medium and by the action of oxidizing agent using the chromatography on thin layer of silica gel. It follows from the results that the compounds at higher temperature immediately decompose both in acidic and alkali media. After the preliminary tests the compounds were hydrolyzed in alkaline medium and in aqueous-ethanol buffer solutions with pH 7, pH 8 and pH 9 at normal and higher temperatures. Because these compounds contain two functional groups in the molecule, the multistage hydrolysis was evaluated by thin-layer chromatography."@en . "78" . "Ni\u017Enanov\u00E1, B." . "RIV/62157124:16370/09:43870774!RIV12-MSM-16370___" . "hydrolysis; stability; derivatives of phenylcarbamic acid; beta-adrenolytics; [(arylcarbonyl)oxy]aminopropanol derivatives"@en . . . . . . "Bez\u00E1kov\u00E1, \u017D." . "0014-8172" . . "8"^^ . "Farmaceutick\u00FD obzor" . . . . "Study of hydrolysis and stability of some potential beta-adrenolytics by thin-layer chromatography"@en . "RIV/62157124:16370/09:43870774" . "6-7" . "Dud\u00E1\u0161ov\u00E1, A." . "V pr\u00E1ci sme \u0161tudovali priebeh hydrol\u00FDzy l\u00E1tok zo skupiny arylkarboxy-am\u00EDnopropanolu s karbam\u00E1tovou substit\u00FAciou na benz\u00E9novom jadre, ktor\u00E9 s\u00FA potencion\u00E1lne beta-adrenolytik\u00E1 s ultrakr\u00E1tkym \u00FA\u010Dinkom. \u0160tudovan\u00E9 l\u00E1tky sa od seba l\u00ED\u0161ia substit\u00FAciou na amino skupine v postrannom re\u0165azci a substit\u00FAciou na karbam\u00E1tovej skupine. Priebeh z\u00E1\u0165a\u017Eov\u00FDch sk\u00FA\u0161ok stability pri dvoch teplot\u00E1ch v kyslom, alkalickom prostred\u00ED a p\u00F4soben\u00EDm oxida\u010Dn\u00E9ho \u010Dinidla sme sledovali pomocou chromatografie na tenkej vrstve silikag\u00E9lu. Z v\u00FDsledkov t\u00FDchto sk\u00FA\u0161ok vyplynulo, \u017Ee sa l\u00E1tky pri zv\u00FD\u0161enej teplote ihne\u010F rozkladaj\u00FA v kyslom aj v alkalickom prostred\u00ED. L\u00E1tky sme po predbe\u017En\u00FDch sk\u00FA\u0161kach podrobili hydrol\u00FDze v alkalickom prostred\u00ED a vo vodno-etanolov\u00FDch tlmiv\u00FDch roztokoch s pH 7, pH 8 a pH 9 za oby\u010Dajnej a zv\u00FD\u0161enej teploty. Nako\u013Eko tieto l\u00E1tky vo svojej molekule obsahuj\u00FA dve funk\u010Dn\u00E9 skupiny, priebeh viacstup\u0148ovej hydrol\u00FDzy sme vyhodnotili pomocou chromatografie na tenkej vrstve." . . "\u0160t\u00FAdium hydrol\u00FDzy a stability niektor\u00FDch potenci\u00E1lnych betaadrenolyt\u00EDk met\u00F3dou chromatografie na tenkej vrstve" . "\u010Cier\u0165a\u017Esk\u00E1, D." . "2"^^ . "344375" . "Cs\u00F6llei, Jozef" . "Ma\u017Eerikov\u00E1, J." . . "Study of hydrolysis and stability of some potential beta-adrenolytics by thin-layer chromatography"@en . . "[21DB37EEDC2D]" .