. . . . . "Effect of Stereoisomery on Antiarrhythmic Impact of Newly Synthesized Compound 44Bu" . "1214-6994" . "Effect of Stereoisomery on Antiarrhythmic Impact of Newly Synthesized Compound 44Bu"@en . "[124ABBABD0AD]" . "Sou\u010Dkov\u00E1, Irena" . "7"^^ . "Vliv stereoizomerie na antiarytmick\u00FD \u00FA\u010Dinek nov\u011B syntetizovan\u00E9 l\u00E1tky 44Bu"@cs . . . "Kolevsk\u00E1, Jana" . "P(NR9126)" . "Effect of Stereoisomery on Antiarrhythmic Impact of Newly Synthesized Compound 44Bu"@en . "RIV/62157124:16370/08:00002066!RIV09-MZ0-16370___" . "Opat\u0159ilov\u00E1, Radka" . "10"^^ . . "RIV/62157124:16370/08:00002066" . "Mokr\u00FD, Petr" . "365259" . "S-isomer and racemate significantly (P<0.01) decrease the occurrence of dangerous types of arrhythmias, such as ventricular tachycardia and ventricular fibrillation against control. Racemate is better than S-isomer but nonsignificantly. Unfortunately it seems, that racemate induces AV blockades. R-isomer proved the pure antiarrhythmic effect, but differences between isomers were nonsignificant. All forms of the 44Bu have an ability to delay the start of arrhythmias. The best postponing effect have racemate and then S-isomer. R-isomer had the smallest impact. After the prophylactic administration of the tested substances the profile (composition) of individual arrhythmia types changed, which is very beneficial, especially when the occurrence of the most dangerous arrhythmias decreases. Racemate and S-isomer have the best decrease on the mortality reduction of aconitine intoxicated animals." . "S-izomer a racem\u00E1t v\u00FDznamn\u011B sni\u017Euj\u00ED v\u00FDskyt nebezpe\u010Dn\u00FDch arytmi\u00ED, nap\u0159. ventrikul\u00E1rn\u00ED tachykardie a ventrikul\u00E1rn\u00ED fibrilace, oproti kontrole. Racem\u00E1t je \u00FA\u010Dinn\u011Bj\u0161\u00ED ne\u017E ne\u017E S-izomer, ale nev\u00FDznamn\u011B. Bohu\u017Eel se zd\u00E1, \u017Ee zp\u016Fsobuje AV blok\u00E1dy. R-izomer vyk\u00E1zal \u010Dist\u00FD antiarytmick\u00FD \u00FA\u010Dinek, ale rozd\u00EDly mezi izomery nebyly signifikantn\u00ED. V\u0161echny formy oddaluj\u00ED n\u00E1stup arytmi\u00ED. Nejlep\u0161\u00ED \u00FA\u010Dinek p\u0159i u\u017E existuj\u00EDc\u00ED arytmii vyk\u00E1zal racem\u00E1t a n\u00E1sledoval S-izomer; R-izomer byl nejm\u00E9n\u011B \u00FA\u010Dinn\u00FD. P\u0159i profylaktick\u00E9m pod\u00E1n\u00ED se zm\u011Bnil charakter arytmi\u00ED, co\u017E je v\u00FDhodn\u00E9 zejm\u00E9na pro zv\u00FD\u0161en\u00FD v\u00FDskyt m\u00E9n\u011B z\u00E1va\u017En\u00FDch forem na \u00FAkor z\u00E1va\u017En\u011Bj\u0161\u00EDch. Racem\u00E1 a S-izomer vyk\u00E1zaly v\u00FDznamn\u011Bj\u0161\u00ED \u00FAbytek mortality zv\u00ED\u0159at."@cs . "S-isomer and racemate significantly (P<0.01) decrease the occurrence of dangerous types of arrhythmias, such as ventricular tachycardia and ventricular fibrillation against control. Racemate is better than S-isomer but nonsignificantly. Unfortunately it seems, that racemate induces AV blockades. R-isomer proved the pure antiarrhythmic effect, but differences between isomers were nonsignificant. All forms of the 44Bu have an ability to delay the start of arrhythmias. The best postponing effect have racemate and then S-isomer. R-isomer had the smallest impact. After the prophylactic administration of the tested substances the profile (composition) of individual arrhythmia types changed, which is very beneficial, especially when the occurrence of the most dangerous arrhythmias decreases. Racemate and S-isomer have the best decrease on the mortality reduction of aconitine intoxicated animals."@en . . "16370" . "Bruncl\u00EDk, V\u00EDt" . "Frydrych, Marek" . . . "Praha" . "Such\u00FD, Pavel" . "Prague Medical Report" . "4"^^ . . "Par\u00E1k, Tom\u00E1\u0161" . . . "Cardiotoxicity; Aconitine; Rat; Stereoisomery; Aryloxyaminopropanols"@en . . . "Barto\u0161ov\u00E1, Ladislava" . . . . "Univerzita Karlova v Praze" . "Vliv stereoizomerie na antiarytmick\u00FD \u00FA\u010Dinek nov\u011B syntetizovan\u00E9 l\u00E1tky 44Bu"@cs . "Effect of Stereoisomery on Antiarrhythmic Impact of Newly Synthesized Compound 44Bu" . . . . "Ber\u00E1nkov\u00E1, Kl\u00E1ra" . .