"Pyrazinecarboxamides; In vitro antimycobacterial activity; Lipophilicity determination"@en . "11"^^ . . "Substituted pyrazine derivatives were synthesized and tested against Mycobacterium tuberculosis strain H37Rv. The hydrophobicity of all the pyrazines was determined using the reversed phase high performance liquid chromatography (RP-HPLC) method (isocratic elution with methanol as an organic modifier in the mobile phase, end-capped non-polar C18 stationary RP column). Experimentally derived Log K values (the logarithm of capacity factor K) were that compared with Log P values calculated by commercially available programmes. The synthetic approach, analytical, spectroscopic, lipophilicity and biological data of ten newly synthesized compounds are presented. Structure?activity relationships among the chemical structure, the antimycobacterial activity of the evaluated compounds are discussed. 3-(3-Methylphenyl)-aminopyrazine-2,5- dicarboxamide (7) has shown the highest activity against M. tuberculosis H37Rv (63% inhibition)."@en . . "Basel" . . "Molecular Diversity Preservation International (MDPI)" . . "Proceedings of 11th International Electronic Conference on Synthetic Organic Chemistry" . "Dole\u017Eal, Martin" . . "Substituovan\u00E9 pyrazin-2,5-dikarboxamidy: synt\u00E9za, hydrofobn\u00ED parametry a antimykobakteri\u00E1ln\u00ED hodnocen\u00ED"@cs . "16370" . . "1"^^ . "Bielesz, Stanislav" . "4"^^ . "Substituovan\u00E9 deriv\u00E1ty pyrazinu byly p\u0159ipraveny a testov\u00E1ny proti Mycobacterium tuberculosis, kmen H37Rv. Hydrofobicita v\u0161ech pyrazinov\u00FDch deriv\u00E1t\u016F by stanovena pomoc\u00ED metody RP-HPLC (isokratick\u00E1 eluce mobiln\u00ED f\u00E1z\u00ED s methanolem jako organick\u00FDm modifik\u00E1torem, kolona s C18 endkapovanou nepol\u00E1rn\u00ED stacion\u00E1rn\u00ED f\u00E1z\u00ED). Experiment\u00E1ln\u011B zji\u0161t\u011Bn\u00E9 hodnoty log K byly porovn\u00E1ny s hodnotami log P vypo\u010D\u00EDtan\u00FDmi komer\u010Dn\u011B dostupn\u00FDmi programy. V \u010Dl\u00E1nku je prezentov\u00E1na synt\u00E9za, analytick\u00E1, lipofilitn\u00ED a biologick\u00E1 data deseti nov\u011B syntetizovan\u00FDch l\u00E1tek. Vztahy mezi strukturou a antimykobakteri\u00E1ln\u00ED aktivitou jsou obsa\u017Eeny v diskusi. Nejvy\u0161\u0161\u00ED aktivitu proti M. tuberculosis H37Rv vyk\u00E1zal 3-(3-Methylfenyl)-aminopyrazin-2,5-dicarboxamid (7) ? 63% inhibice."@cs . "Substituted pyrazine-2,5-dicarboxamides: Synthesis, Hydrophobicity Parameters and Antimycobacterial Evaluation"@en . . "RIV/62157124:16370/07:00001121!RIV08-MSM-16370___" . "[DD52AB81C381]" . "RIV/62157124:16370/07:00001121" . "3-906980-19-7" . "Substituovan\u00E9 pyrazin-2,5-dikarboxamidy: synt\u00E9za, hydrofobn\u00ED parametry a antimykobakteri\u00E1ln\u00ED hodnocen\u00ED"@cs . "Substituted pyrazine-2,5-dicarboxamides: Synthesis, Hydrophobicity Parameters and Antimycobacterial Evaluation" . "Kune\u0161, Ji\u0159\u00ED" . . . . . "005-015" . . "453429" . "Jamp\u00EDlek, Josef" . . "Substituted pyrazine-2,5-dicarboxamides: Synthesis, Hydrophobicity Parameters and Antimycobacterial Evaluation"@en . "Substituted pyrazine derivatives were synthesized and tested against Mycobacterium tuberculosis strain H37Rv. The hydrophobicity of all the pyrazines was determined using the reversed phase high performance liquid chromatography (RP-HPLC) method (isocratic elution with methanol as an organic modifier in the mobile phase, end-capped non-polar C18 stationary RP column). Experimentally derived Log K values (the logarithm of capacity factor K) were that compared with Log P values calculated by commercially available programmes. The synthetic approach, analytical, spectroscopic, lipophilicity and biological data of ten newly synthesized compounds are presented. Structure?activity relationships among the chemical structure, the antimycobacterial activity of the evaluated compounds are discussed. 3-(3-Methylphenyl)-aminopyrazine-2,5- dicarboxamide (7) has shown the highest activity against M. tuberculosis H37Rv (63% inhibition)." . . "S" . "Substituted pyrazine-2,5-dicarboxamides: Synthesis, Hydrophobicity Parameters and Antimycobacterial Evaluation" .