. "Antiradical activity of different copper(II) Schiff base complexes and their effect on alloxan-induced diabetes"@cs . "7"^^ . "0946-672X" . "18" . . "[C41532535D65]" . "Antiradical activity of different copper(II) Schiff base complexes and their effect on alloxan-induced diabetes"@en . "554844" . "RIV/62157124:16370/04:00000089" . . . "\u0160vajlenov\u00E1, O\u013Ega" . "5"^^ . "Antiradical activity of different copper(II) Schiff base complexes and their effect on alloxan-induced diabetes"@cs . "Considering the important role of antioxidants in biological systems, the group of copper(II) complexes derived from salicylaldehyde and alpha- or beta-alanine and its thiourea derivative and copper(II) complexes derived from pyruvic acid and beta-alanine were studied. The antiradical activity of the tested compounds was studied by both in vitro and in vivo methods. The chemical methods based on inhibition of INT-formazane or 3-nitrotyrosine formation were used for the evaluation of SOD-mimic and antiperoxynitrite activity, respectively. In the case of in vivo activity evaluation, an alloxan-induced diabetes mellitus model in mice was used, the mechanism of action of alloxan being closely connected with the formation of free radicals selectively damaging the pancreatic beta-cells. Since all the substances studied showed different positive effects, it is obvious that they have not acted only as a source of copper(II) ions but their effect is related to their specific chelate structure. The obtained res" . "2" . "Van\u010Do, J." . "Valentov\u00E1, Jindra" . . . . "Considering the important role of antioxidants in biological systems, the group of copper(II) complexes derived from salicylaldehyde and alpha- or beta-alanine and its thiourea derivative and copper(II) complexes derived from pyruvic acid and beta-alanine were studied. The antiradical activity of the tested compounds was studied by both in vitro and in vivo methods. The chemical methods based on inhibition of INT-formazane or 3-nitrotyrosine formation were used for the evaluation of SOD-mimic and antiperoxynitrite activity, respectively. In the case of in vivo activity evaluation, an alloxan-induced diabetes mellitus model in mice was used, the mechanism of action of alloxan being closely connected with the formation of free radicals selectively damaging the pancreatic beta-cells. Since all the substances studied showed different positive effects, it is obvious that they have not acted only as a source of copper(II) ions but their effect is related to their specific chelate structure. The obtained res"@en . "copper(II) complexes;antiradical activity"@en . "Antiradical activity of different copper(II) Schiff base complexes and their effect on alloxan-induced diabetes" . . "2"^^ . "Journal of Trace Elements in Medicine and Biology" . "16370" . . . "155-161" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Antiradical activity of different copper(II) Schiff base complexes and their effect on alloxan-induced diabetes"@cs . "Ra\u010Dansk\u00E1, Eva" . "Z(MSM 163700003)" . "Antiradical activity of different copper(II) Schiff base complexes and their effect on alloxan-induced diabetes" . . "Musel\u00EDk, J." . . . "Antiradical activity of different copper(II) Schiff base complexes and their effect on alloxan-induced diabetes"@en . "RIV/62157124:16370/04:00000089!RIV/2005/MSM/163705/N" . . .