. "CZ - \u010Cesk\u00E1 republika" . "8"^^ . "7"^^ . . "16370" . "Vliv nov\u00FD ultrakr\u00E1tce p\u016Fsob\u00EDc\u00EDch beta adrenergn\u00EDch blok\u00E1tor\u016F na systolick\u00FD krevn\u00ED tlak laboratorn\u00EDho potkana"@cs . "RIV/62157124:16370/04:00000014" . "Influence of New Ultrashort-Acting Beta-Adrenergic Blockers on Systolic Blood Pressure in Rats" . . "Bruncl\u00EDk, V\u00EDt" . "181-185" . "Kr\u010Dm\u00E1\u0159, Josef" . "Florian, Tom\u00E1\u0161" . . "Mokr\u00FD, Petr" . . "Z(MSM 163700003)" . . "Barto\u0161ov\u00E1, Ladislava" . "Ne\u010Das, Ji\u0159\u00ED" . . "Frydrych, Marek" . . "Vliv nov\u00FD ultrakr\u00E1tce p\u016Fsob\u00EDc\u00EDch beta adrenergn\u00EDch blok\u00E1tor\u016F na systolick\u00FD krevn\u00ED tlak laboratorn\u00EDho potkana"@cs . "pharmacology; plasma esterases; ester functional group; universal perfusion system; hypotensive effect"@en . "5"^^ . . "Influence of New Ultrashort-Acting Beta-Adrenergic Blockers on Systolic Blood Pressure in Rats" . . "567944" . "V t\u00E9to experimant\u00E1ln\u00ED pr\u00E1ci byly testov\u00E1ny t\u0159i nov\u011B syntetizovan\u00E9 ultrakr\u00E1tce p\u016Fsob\u00EDc\u00ED beta adrenergn\u00ED blok\u00E1tory obsahuj\u00EDc\u00ED ve sv\u00E9 struktu\u0159e esterovou funk\u010Dn\u00ED skupinu, kter\u00E1 je snadno \u0161t\u011Bpiteln\u00E1 plazmatick\u00FDmi ester\u00E1zami. Testovan\u00E1 skupina zv\u00ED\u0159at obsahovala 30 laboratorn\u00EDch potkan\u016F rozd\u011Blen\u00FDch do t\u0159\u00ED podskupin. L\u00E1tka 42Bu byla pod\u00E1v\u00E1na prvn\u00ED skupin\u011B (8 potkan\u016F), l\u00E1tka 43Bu druh\u00E9 skupin\u011B (8 potkan\u016F), l\u00E1tka 44Bu t\u0159et\u00ED skupin\u011B (8 potkan\u016F) a \u010Dtvrt\u00E9 skupin\u011B bylo pod\u00E1v\u00E1no placebo (6 potkan\u016F). V celkov\u00E9 anest\u00E9zii byly vypreparov\u00E1ny arteria carotis a vena jugularis. Arteria carotis byla p\u0159ipojena na p\u0159\u00EDstroj HSE UNIPER UP-100, co\u017E je univerz\u00E1ln\u00ED perf\u00FAzn\u00ED syst\u00E9m pro izolovan\u00E9 org\u00E1ny sn\u00EDmaj\u00EDc\u00ED a p\u0159ev\u00E1d\u011Bj\u00EDc\u00ED aktu\u00E1ln\u00ED hodnoty krevn\u00EDho tlaku na grafick\u00FD z\u00E1znam do PC. N\u00E1sledn\u011B byly do vena jugularis jednor\u00E1zov\u011B injikov\u00E1ny roztoky l\u00E1tek 42Bu, 43Bu, 44Bu a placeba a hodnoty krevn\u00EDho tlaku byly sn\u00EDm\u00E1ny po dobu 18 minut od aplikace. L\u00E1tky 42Bu, 43Bu a 44Bu byly aplikov\u00E1ny v d\u00E1vce 2,5 mg/kg. Zkouman\u00E9 l\u00E1tky byly porovn\u00E1ny"@cs . "0001-7213" . . "Barto\u0161\u00EDkov\u00E1, Lenka" . . . "Three newly synthesized potential ultrashort-acting beta adrenergic blockers containing metabolically unstable ester functional groups that are easily cleft by plasma esterases were tested. In the experiment, 30 laboratory rats divided into 4 subgroups were used. Agent 42Bu was administered to Group 1 (n = 8), agent 43Bu to Group 2 (n = 8), agent 44Bu to Group 3 (n = 8) and placebo to Group 4 (n = 6). Under general anesthesia the arteria carotis and vena jugularis were exteriorized. The arteria carotis was connected by a cannula to the machine HSE UNIPER UP 100, a universal perfusion system for isolated organs recording and converting actual values of blood pressure into graphical representation in a computer. Subsequently, 42Bu, 43Bu, 44Bu and placebo were administered into v. jugularis, and systolic blood pressure was recorded within the period of 18 minutes of their administration. All agents were administered at 2.5 mg/kg doses. The systolic blood pressure values after 42Bu, 43Bu, 44Bu administrat"@en . "Influence of New Ultrashort-Acting Beta-Adrenergic Blockers on Systolic Blood Pressure in Rats"@en . "Influence of New Ultrashort-Acting Beta-Adrenergic Blockers on Systolic Blood Pressure in Rats"@en . . "RIV/62157124:16370/04:00000014!RIV06-MSM-16370___" . . . . "Acta veterinaria Brno" . . "[F54A2D9F5065]" . . "Three newly synthesized potential ultrashort-acting beta adrenergic blockers containing metabolically unstable ester functional groups that are easily cleft by plasma esterases were tested. In the experiment, 30 laboratory rats divided into 4 subgroups were used. Agent 42Bu was administered to Group 1 (n = 8), agent 43Bu to Group 2 (n = 8), agent 44Bu to Group 3 (n = 8) and placebo to Group 4 (n = 6). Under general anesthesia the arteria carotis and vena jugularis were exteriorized. The arteria carotis was connected by a cannula to the machine HSE UNIPER UP 100, a universal perfusion system for isolated organs recording and converting actual values of blood pressure into graphical representation in a computer. Subsequently, 42Bu, 43Bu, 44Bu and placebo were administered into v. jugularis, and systolic blood pressure was recorded within the period of 18 minutes of their administration. All agents were administered at 2.5 mg/kg doses. The systolic blood pressure values after 42Bu, 43Bu, 44Bu administrat" . . . . "1" . . "1" .