"Interdisciplinary Toxicology" . . "[FD20F06635F0]" . "The present experiment was aimed at assessing the application of neostigmine, an acetylcholinesterase (AChE) pseudo-irreversible inhibitor with poor penetration through the hematoencephalitic barrier, and the neurotransmitter acetylcholine (ACh). The experiment was done to evaluate their ability to modulate an infectious disease: tularemia. Mice infected with Francisella tularensis and exposed to either ACh or neostigmine had a higher mortality and spleen bacterial burden when compared to infected mice exposed to saline solution only. The activated cholinergic anti-inflammatory pathway suppressed pathways necessary for tularemia resolution. Administration of AChE inhibitors to the individuals suffering from tularemia is contra-indicatory. Drugs based on AChE inhibition should be restricted when tularemia or disease with a similar pathogenesis is suspected."@en . "Pikula, Ji\u0159\u00ED" . . "Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in BALB/c mice" . . "cholinergic anti-inflammatory pathway; parasympathicus; cholinergic system; immunomodulation; intracellular pathogen; Francisella tularensis"@en . . . "120888" . "5" . "1" . "Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in BALB/c mice"@en . "Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in BALB/c mice"@en . "1337-6853" . . . . . . . "16270" . . . "10.2478/v10102-012-0004-7" . . "RIV/62157124:16270/12:43871483!RIV13-MSM-16270___" . "RIV/62157124:16270/12:43871483" . . "Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in BALB/c mice" . "4"^^ . "Pavli\u0161, Oto" . . . "4"^^ . "1"^^ . "P(LH11023), V" . "SK - Slovensk\u00E1 republika" . . "Svobodov\u00E1, Hana" . . "Pohanka, Miroslav" . "The present experiment was aimed at assessing the application of neostigmine, an acetylcholinesterase (AChE) pseudo-irreversible inhibitor with poor penetration through the hematoencephalitic barrier, and the neurotransmitter acetylcholine (ACh). The experiment was done to evaluate their ability to modulate an infectious disease: tularemia. Mice infected with Francisella tularensis and exposed to either ACh or neostigmine had a higher mortality and spleen bacterial burden when compared to infected mice exposed to saline solution only. The activated cholinergic anti-inflammatory pathway suppressed pathways necessary for tularemia resolution. Administration of AChE inhibitors to the individuals suffering from tularemia is contra-indicatory. Drugs based on AChE inhibition should be restricted when tularemia or disease with a similar pathogenesis is suspected." . .