. "CZ - \u010Cesk\u00E1 republika" . . "Use of Crustacean Artemia franciscana for Alternative Biotests"@en . . "Dvo\u0159\u00E1k, Petr" . . "Use of Crustacean Artemia franciscana for Alternative Biotests" . . "294659" . "2"^^ . "Be\u0148ov\u00E1, Katar\u00EDna" . . "Artemia salina; Synergy effects; irradiation; pharmacotoxicology"@en . . "Sklen\u00E1\u0159, Zbyn\u011Bk" . "9" . "RIV/62157124:16270/10:00002769" . "Z(MSM6215712402)" . . "Usage of crustacean Artemia franciscana for alternative biotests of the second generation was studied, and possible experimental design and applications of such tests outlined. In addition to the classical use in ecotoxicology, the test can be used in pharmacology as well or to monitor the effects of ionizing radiation in co-exposure with some chemical compounds. The synergistic effect of co-exposure of PCB (DELOR 103), cadmium chloride and potassium dichromate with beta 89Sr irradiation was shown. We also demonstrated the anti-oxidative and pro-oxidative effects of the ascorbic acid in dependence on its concentration. Use of the pharmaco-toxicological screening in search for the novel inhibitors of cyklin-dependent kinases was demonstrated as well, showing that Artemia franciscana may be used as a suitable biosensor instead of the expensive tests on higher vertebrates."@en . . "5"^^ . "16270" . . "RIV/62157124:16270/10:00002769!RIV11-MSM-16270___" . "[A45CA73D77A5]" . . "Usage of crustacean Artemia franciscana for alternative biotests of the second generation was studied, and possible experimental design and applications of such tests outlined. In addition to the classical use in ecotoxicology, the test can be used in pharmacology as well or to monitor the effects of ionizing radiation in co-exposure with some chemical compounds. The synergistic effect of co-exposure of PCB (DELOR 103), cadmium chloride and potassium dichromate with beta 89Sr irradiation was shown. We also demonstrated the anti-oxidative and pro-oxidative effects of the ascorbic acid in dependence on its concentration. Use of the pharmaco-toxicological screening in search for the novel inhibitors of cyklin-dependent kinases was demonstrated as well, showing that Artemia franciscana may be used as a suitable biosensor instead of the expensive tests on higher vertebrates." . "79" . "Acta veterinaria Brno" . . "000282195800008" . "Havelkov\u00E1, Alena" . "\u017Dd\u00E1rsk\u00FD, Michal" . "Use of Crustacean Artemia franciscana for Alternative Biotests" . . . "Use of Crustacean Artemia franciscana for Alternative Biotests"@en . . "7"^^ . . . "0001-7213" .