"4" . . . "CZ - \u010Cesk\u00E1 republika" . "75" . . "[A7DA35034D8B]" . "Brominated flame retardants (BFRs) are organic substances frequently used in many industries. The most important group within BFRs are polybrominated diphenyl ethers (PBDEs). Because they persist in the environment, get accumulated in food chains and have toxic effects, they are a potential health risk for both animals and man. Polybrominated diphenyl ethers may disrupt processes of hormonal regulation in living organisms by reducing thyroxine concentrations in the plasma of exposed individuals. In vitro studies have demonstrated the ability of these substances to bind to estrogen and androgen receptors. Tests on rodents have also demonstrated neurotoxicity of some of the PBDEs. Although industrial use of PBDEs is now regulated to a large extent, PBDEs have already been detected in areas with no apparent industrial load, e.g. in Greenland. This article presents an overview of BFRs-related issues with a particular emphasis on PBDEs, describes toxic effects of those substances and their metabolism in li"@en . "RIV/62157124:16270/06:00000967!RIV07-MSM-16270___" . . "Brominated flame retardants in the environment: their sources and effects (review)." . . . "13"^^ . "587-599" . "Svobodov\u00E1, Zde\u0148ka" . "BFRs; polybrominated diphenyl ethers; tetrabromobisphenol A; environmental endocrine disruptors; toxicity; metabolism"@en . . "467421" . . . . . "Z(MSM6215712402)" . "0001-7213" . "Brominated flame retardants in the environment: their sources and effects (review)."@en . "16270" . . . "Bromovan\u00E9 zpomalova\u010De ho\u0159en\u00ED (BFRs) jsou organick\u00E9 l\u00E1tky pou\u017E\u00EDvan\u00E9 v mnoha odv\u011Btv\u00EDch pr\u016Fmyslu. Nejd\u016Fle\u017Eit\u011Bj\u0161\u00ED skupinou BFRs jsou polybromovan\u00E9 difenyl\u00E9tery (PBDEs), kter\u00E9 z d\u016Fvodu sv\u00E9 persistence v \u017Eivotn\u00EDm prost\u0159ed\u00ED, akumulace v potravn\u00EDch \u0159et\u011Bzc\u00EDch a toxick\u00FDch \u00FA\u010Dink\u016F p\u0159edstavuj\u00ED potenci\u00E1ln\u00ED nebezpe\u010D\u00ED ohro\u017Een\u00ED zdrav\u00ED zv\u00ED\u0159at a \u010Dlov\u011Bka. Polybromovan\u00E9 difenyl\u00E9tery vykazuj\u00ED schopnost naru\u0161en\u00ED proces\u016F hormon\u00E1ln\u00ED regulace v \u017Eiv\u00FDch organismech sni\u017Eov\u00E1n\u00EDm koncentrac\u00ED thyroxinu v plasm\u011B exponovan\u00FDch jedinc\u016F. In vitro studie prok\u00E1zaly schopnost vazby t\u011Bchto l\u00E1tek na estrogenn\u00ED \u010Di androgenn\u00ED receptory. V pokusech na hlodavc\u00EDch byla zji\u0161t\u011Bna tak\u00E9 neurotoxicita n\u011Bkter\u00FDch PBDEs. P\u0159esto\u017Ee je pou\u017E\u00EDv\u00E1n\u00ED PBDEs v pr\u016Fmyslu v sou\u010Dasnosti do zna\u010Dn\u00E9 m\u00EDry regulov\u00E1no, v\u00FDskyt t\u011Bchto l\u00E1tek ji\u017E byl zaznamen\u00E1n tak\u00E9 v oblastech bez zjevn\u00E9ho pr\u016Fmyslov\u00E9ho zat\u00ED\u017Een\u00ED nap\u0159. v Gr\u00F3nsku. P\u0159edkl\u00E1dan\u00FD \u010Dl\u00E1nek shrnuje poznatky t\u00FDkaj\u00EDc\u00ED se problematiky BFRs se zam\u011B\u0159en\u00EDm na PBDEs, popisuje toxick\u00E9 \u00FA\u010Dinky t\u011Bchto l\u00E1tek a jejich metabolismus v \u017Eiv"@cs . "Bromovan\u00E9 zpomalova\u010De ho\u0159en\u00ED: zdroje a \u00FA\u010Dinky - review."@cs . "Bromovan\u00E9 zpomalova\u010De ho\u0159en\u00ED: zdroje a \u00FA\u010Dinky - review."@cs . . . . "1"^^ . . . "Brominated flame retardants (BFRs) are organic substances frequently used in many industries. The most important group within BFRs are polybrominated diphenyl ethers (PBDEs). Because they persist in the environment, get accumulated in food chains and have toxic effects, they are a potential health risk for both animals and man. Polybrominated diphenyl ethers may disrupt processes of hormonal regulation in living organisms by reducing thyroxine concentrations in the plasma of exposed individuals. In vitro studies have demonstrated the ability of these substances to bind to estrogen and androgen receptors. Tests on rodents have also demonstrated neurotoxicity of some of the PBDEs. Although industrial use of PBDEs is now regulated to a large extent, PBDEs have already been detected in areas with no apparent industrial load, e.g. in Greenland. This article presents an overview of BFRs-related issues with a particular emphasis on PBDEs, describes toxic effects of those substances and their metabolism in li" . "Mikula, P\u0159emysl" . "Brominated flame retardants in the environment: their sources and effects (review)."@en . "Brominated flame retardants in the environment: their sources and effects (review)." . "RIV/62157124:16270/06:00000967" . "2"^^ . "Acta veterinaria Brno" .